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THE SIGNIFICANCE OF PHARMACOGENETIC CYP2C19 TESTING FOR PERSONALIZATION OF THE ANTIPLATELET THERAPY IN CARDIOLOGY PRACTICE

https://doi.org/10.20996/1819-6446-2013-9-4-404-408

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Abstract

The clinical significance  of CYP2C19 genetic polymorphism, associated with the violation of the formation of the active clopidogrel metabolite, for efficacy and safety of this drug in cardiology practice is discussed. Approaches to antiplatelet agent choice according to pharmacogenetic CYP2C19 testing, as well as the indications for this approach use in clinical practice are presented. Consideration of these testing results should increase the efficacy and safety of antiplatelet treatment.

About the Authors

K. B. Mirzaev
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation


D. A. Sychev
I.M. Sechenov First Moscow State Medical University, Center for Clinical Pharmacology, Research Center for Evaluation of Medical Products, Moscow
Russian Federation


D. A. Andreev
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation


A. B. Prokofiev
I.M. Sechenov First Moscow State Medical University, Center for Clinical Pharmacology, Research Center for Evaluation of Medical Products, Moscow
Russian Federation


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For citation:


Mirzaev K.B., Sychev D.A., Andreev D.A., Prokofiev A.B. THE SIGNIFICANCE OF PHARMACOGENETIC CYP2C19 TESTING FOR PERSONALIZATION OF THE ANTIPLATELET THERAPY IN CARDIOLOGY PRACTICE. Rational Pharmacotherapy in Cardiology. 2013;9(4):404-408. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-4-404-408

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