Rational Pharmacotherapy in Cardiology

Advanced search


Full Text:


Aim. To assess (on the basis of Russian national guidelines on arterial hypertension (HT), 2004) quality of pharmacotherapy measures among hypertensive patients observed in primary care practice. Material and methods. Data on 12 604 patients with HT (7 819 women, 4 785 men, aged 59.5±12.0 years) from 13 regions of Russia observed in primary care units during 2007 were enrolled in the study. Compliance with recommendations on decision making about pharmacotherapy need (risk category assessment) and adequacy were evaluated. Results. 64% of patients with HT had no drug prescriptions in their outpatient card in 2007. 4 880 patients from 12 604 enrolled HT patients (38.7%) had all data necessary for risk assessment. 3920 patients (31% of the whole studied group) had pharmacotherapy indications (high or very high risk). Only 819 HT patients (6.5% of the whole number of enrolled patients) had antihypertensive pharmacotherapy completely corresponding to their clinical status. Conclusion. The quality of pharmacotherapy measures carried out in primary care practice during 2007 did not conform to HT guidelines.

About the Authors

O. M. Posnenkova
Saratov Research Institute for Cardiology
Russian Federation

A. R. Kiselev
Saratov Research Institute for Cardiology
Russian Federation

V. I. Gridnev
Saratov Research Institute for Cardiology
Russian Federation

V. A. Shvartz
Saratov Research Institute for Cardiology
Russian Federation

P. Ya. Dovgalevsky
Saratov Research Institute for Cardiology
Russian Federation

E. V. Oschepkova
Russian Cardiology Research and Production Complex
Russian Federation


1. Conroy R.M., Pyörälä K., Fitzgerald A.P. et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 2003; 24: 987-1003.

2. Ong K.L., Cheung B.M.Y., Man Y. B. et al. Prevalence, Awareness, Treatment, and Control of Hypertension Among United States Adults 1999–2004. Journal of American Heart Association 2007; 49: 69-75.

3. Martino M.D., Veronesi C., Esposti L.D. et al. Adherence to antihypertensive drug treatment and blood pressure control: a real practice analysis in Italy. Journal of Human Hypertension 2008; 22: 51-53.

4. Chazova I.E. Treatment of arterial hypertension: current conception. Ter Arkh 2007;79(9):5-8. Russian (Чазова И.Е. Лечение артериальной гипертонии: современные представления. Терапевтический архив 2007; 79(9): 5-8).

5. Oshchepkova E.V. Five-year results of implementation of the federal target program Prevention and Treatment of Arterial Hypertension in Russian Federation (2002-2006). Ter Arkh 2007;79(9):25-30. Russian (Ощепкова Е.В. Пятилетние итоги реализации федеральной целевой программы «Профилактика и лечение артериальной гипертонии в Российской Федерации» (2002-2006 гг.). Терапевтический архив 2007; 79(9): 25-30.

6. Evstifeeva S.E., Gridnev V.I., Oshchepkova E.V. 4th School physicians Register hypertension. Evaluation of therapeutic and preventive care to patients with hypertension in primary health care (according to the Register of hypertension). Atmosfera. Kardiologiya 2007; (4): 18-20. Russian (Евстифеева С.Е., Гриднев В.И., Ощепкова Е.В. 4-я Школа врачей Регистра АГ. Оценка лечебно-профилактической помощи больным артериальной гипертонией в первичном звене здравоохранения (по данным Регистра АГ). Атмосфера. Кардиология 2007; (4): 18-20).

7. Beers M.H., Munkata M., Storrie M. The accuracy of medication histories in hospital medical records of elderly persons. J Am Geriatr Soc 1990; 38: 1183-1187.

8. Hocking G., Kalyanaraman R., deMello W.F. Better drug history taking: an assessment of the DRUGS mnemonic. J R Soc Med 1998; 91: 305.

9. Tam V.C., Knowles S.R., Cornish P.L. et al. Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review. CMAJ 2005; 173 (5): 510-515.

10. Dobrzanski S., Hammond I., Khan G. et al. The nature of hospital prescribing errors. Br J Clin Govern 2002; 7: 187-193.

11. Drewett N.M. Stop regular medicine errors. Pharmacy in Practice 1998; (8): 193-196.

12. Nicholls M., Horler K., Campbell D. et al. Medicines. Peace in a POD (patients’ own drug). Health Serv J 2001; 111: 35.

13. Cornish P., Knowles S., Marchesano R. et al. Unintended medication discrepancies at the time of hospital admission. Arch Intern Med 2005; 165: 424-429.

14. Akwagyriam I., Goodyer L.I., Harding L. et al. Drug history taking and the identification of drug related problems in an accident and emergency department. J Accid Emerg Med 1996; 13: 166-168.

15. Gleason K.M., Groszek J.M., Sullivan C. et al. Reconciliation of discrepancies in medication histories and admission orders of newly hospitalized patients. Am J Health Syst Pharm 2004; 61: 1689-1695.

16. Truitt C.A. Longe R.L., Taylor A.T. An evaluation of a medication history method. Drug Intell Clin Pharm 1982; 16: 592-595.

17. Lau H.S., Florax C., Porsius A.J. et al. The completeness of medication histories in hospital medical records of patients admitted to general internal medicine wards. Br J Clin Pharmacol 2000; 49: 597-603.

18. Vyalkov A.I., Vorob'ev P.A. State of the system of quality management in health care. Problemy Standartizatsii v Zdravookhranenii 2005; (12): 3-8. Russian (Вялков А.И., Воробьев П.А. Состояние системы управления качеством в здравоохранении. Проблемы стандартизации в здравоохранении 2005; (12): 3-8).

19. Sinyavskiy V.M., Zhuravlev V.A. The organization of system management, accounting and control in the outpatient service. Vrach i Informatsionnye Tekhnologii 2006; (2): 15-19. Russian (Синявский В.М., Журавлев В.А. Организация системного управления, учета и контроля в амбулаторно-поликлинической службе. Врач и информационные технологии 2006; (2): 15-19).

20. National guidelines for diagnosis and treatment of hypertension. Kardiovaskulyarnaya Terapiya i Profilaktika 2008; 7(6) suppl 2: 1-36. Russian (Национальные рекомендации по диагностике и лечению артериальной гипертонии. Кардиоваскулярная терапия и профилактика 2008; 7(6) Приложение 2: 1-36).

21. Pocock S.J., McCormack V., Gueyffier F. et al. A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials. BMJ 2001; 323: 75-81.


For citations:

Posnenkova O.M., Kiselev A.R., Gridnev V.I., Shvartz V.A., Dovgalevsky P.Y., Oschepkova E.V. PHARMACOTHERAPY QUALITY IN PATIENTS WITH ARTERIAL HYPERTENSION OBSERVED IN PRIMARY CARE PRACTICE. HYPERTENSION REGISTER DATA. Rational Pharmacotherapy in Cardiology. 2011;7(6):725-732. (In Russ.)

Views: 545

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)