Preview

Rational Pharmacotherapy in Cardiology

Advanced search

OMEGA-3 FATTY ACIDS AND AGE-RELATED DISEASES: REALITIES AND PROSPECTS

https://doi.org/10.20996/1819-6446-2015-11-3-309-316

Full Text:

Abstract

Efficacy of omega-3 fatty acids in cardiology is so high that in many countries omega-3 fatty acids are included into the treatment protocols for patients with cardiovascular diseases. This therapeutic class slows down oxidative stress and chronic inflammation processes, thereby providing a significant contribution to the complex treatment of hypertension. Besides, omega-3 fatty acids slow down the aging process and prevent the development of age-related diseases affecting the rate of telomere shortening.

About the Authors

O. M. Drapkina
I.M. Sechenov First Moscow State Medical University
Russian Federation
Trubetskaya ul. 8-2, Moscow, 119991 Russia


R. N. Shepel'
I.M. Sechenov First Moscow State Medical University
Russian Federation
Trubetskaya ul. 8-2, Moscow, 119991 Russia


References

1. Dyerberg J., Bang H.O., Hjorne N. Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr. 1975; 28: 958-66.

2. Harris W.S. ω-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 1997; 65(5 Suppl.): 1645S-1654S.

3. ErkkiläA.T., Lichtenstein A.H., Mozaffarian D., Herrington D.M. Fish intake is associated with a reduced progression of сoronary artery atherosclerosis in postmenopausal women with coronary artery disease. Am J Clin Nutr 2004; 80(3): 626-32.

4. von Schacky C., Angerer P., Kothny W. et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1999; 130(7): 554-62.

5. Reiffel J.A., McDonald A. Antiarrhythmic effects of omega-3 fatty acids. Am J Cardiol 2006; 98(4A): 50i-60i.

6. Rosenberg I.H. Fish — food to calm the heart. N Engl J Med 2002; 346(15): 1102-3.

7. Das U.N. Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension. Eur J Clin Nutr 2004 (58): 195-203.

8. Rasmussen B.M., Vessby B., Uusitupa M., et al., Kanwu study group, et al. Effects of dietary saturated, monounsaturated, and ω-3 fatty acids on blood pressure in healthy Subjects. Am J Clin Nutr 2006; 83: 221-6.

9. Shah A.P., Ichiuji A.M., Han J.K., et al. Cardiovascular and endothelial effects of fish oil supplementation in healthy Volunteers. J Cardiovasc Pharmacol There 2007; 12: 213-9.

10. Appel LJ; Miller III ER, Seidler AJ, Whelton PK. Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993;153(12):1429-38.

11. Geleijnse J.M., Giltay E.J., Grobbee D.E., et al. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 2002(20): 1493-9.

12. Marchioli R., Barzi F., Bomba E., et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI) Prevenzione. Circulation 2002; 105: 1897-903

13. Albert C.M., Campos H., Stampfer M.J., et al. Blood levels of longchain n-3 fatty acids and the risk of sudden death. N Engl J Med 2002; 346: 1113-8.

14. Hartweg J, Farmer AJ, Holman RR, Neil HA. Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes. Diabetologia 2007; 50(2): 250-8.

15. Hartweg J., Farmera A.J., Holmanb R., Neil A. Potential Impact of omega-3 Treatment on cardiovascular disease in type 2 diabetes. Curr Opin Lipidol 2009; 20: 30-8.

16. Damsgaard C.T., Schack-Nielsen L., Michaelsen K.F., et al. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants. J Nutr 2006; 36(1): 94-9.

17. Lucas A., Fewtrell M.S., Cole T.J. Fetal origins of adult disease-the hypothesis revisited. BMJ 1999; 319: 245-249.

18. Owen C.G., Whincup P.H., Odoki K., et al. Infant feeding and blood cholesterol: a study in adolescents and a systematic review. Pediatrics 2002; 110: 597-608.

19. Singhal A., Cole T.J., Lucas A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 2001; 357: 413-9.

20. Lauritzen L., Hansen H.S., Jorgensen M.H., Michaelsen K.F. The essentiality of long chain ω-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 2001; 40: 1-94.

21. Armitage J.A., Pearce A.D., Sinclair A.J., et al. Increased blood pressure later in life may be associated with perinatal ω-3 fatty acid deficiency. Lipids 2003; 38: 459-64.

22. Forsyth J.S., Willatts P., Agostoni C., et al. Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial. BMJ 2003; 326: 953-7.

23. Harris W.S., von Schacky C. The omega-3 index: a new risk factor for death from coronary heart disease. Prev Med 2004; 39: 212-20.

24. Bikbov BT, Tomilina NA. Condition replacement therapy in patients with chronic renal failure in the Russian Federation in 1998-2009 years. Report to the Russian Register of renal replacement therapy. Nefrologiya i Dializ 2014; 16 (1): 11-127. Russian (Бикбов Б. Т., Томилина Н. А. Состояние заместительной терапии больных с хронической почечной недостаточностью в Российской Федерации в 1998-2009 гг. Отчет по данным Российского регистра заместительной почечной терапии. Нефрология и Диализ 2014; 16(1):11-127).

25. Vernaglione L., Cristofano C., Chimienti S.Omega-3polyunsaturated fatty acids and proxies of cardiovascular disease in hemodialysis: a prospective cohort study. J Nephrol 2008; 21: 99-105.

26. Lankin VZ, Postnov AY, Rodnenkov AY, et al. Oxidative stress is a risk factor for complications of cardiovascular diseases and premature aging under the influence of adverse climatic conditions. Kardiologicheskiy Vestnik 2013; 8 (1): 22-5. Russian (Ланкин В.З., Постнов А.Ю., Родненков А.Ю. и др. Окислительный стресс как фактор риска осложнения сердечно-сосудистых заболеваний и преждевременного старения при действии неблагоприятных климатических условий. Кардиологический Вестник 2013; 8(1): 22-5).

27. Drapkina OM, Shepel RN Modern ideas about the role of telomeres and telomerase in the pathogenesis of hypertension. Arterial'naya Gipertenziya 2013; 19 (4): 290-8. Russian (Драпкина О.М., Шепель Р.Н. Современные представления о роли теломер и теломеразы в патогенезе гипертонической болезни. Артериальная Гипертензия 2013; 19(4): 290-8).

28. Ivashkin VT Molecular interactions between telomeres and mitochondria diseases of aging. Available at: http://internist.ru/publications/detail/6921/. Accessed by 05/18/2015. Russian (Ивашкин В.Т. Молекулярные взаимодействия между теломерами, митохондриями и болезни старения. Доступно на: http://internist.ru/publications/detail/6921/. Проверено 18.05.2015).

29. Drapkina OM, Shepel RN. Telomeres and telomerase complex. The main manifestations of the genetic fault. Kardiovaskulyarnaya Terapiya i Profilaktika 2015; 1: 70-7. Russian (Драпкина О.М., Шепель Р.Н. Теломеры и теломеразный комплекс. Основные проявления генетического сбоя. Кардиоваскулярная Терапия и Профилактика 2015;1: 70-7).

30. Drapkina OM, Shepel RN. Telomeres and chronic heart failure. Kardiologiia 2014; 54 (4): 60-7. Russian (Драпкина О.М., Шепель Р.Н. Теломеры и хроническая сердечная недостаточность. Кардиология 2014; 54(4): 60-7).

31. Finch C.E., Crimmins E.M. Inflammatory exposure and historical changes in human life-spans. Science 2004; 305: 1736-9.

32. Xu D., Neville R., Finkel T. Homocysteine accelerates endothelial cell senescence. FEBS Lett 2000; 470: 20-4.

33. Breitschopf K., Zeiher A.M., Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett 2001; 493: 21-5.

34. Kurz DJ, Decary S, Hong Y, et al. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004; 117: 2417-26.

35. Imanishi T., Hano T., Nishio I. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. J Hypertens 2005; 23:1699-706.

36. Farzaneh-Far R., Lin J., Epel E.S., et al. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA 2010; 303: 250-7.

37. Weng N.P., Levine B.L., June C.H., Hodes R.J. Regulated expression of telomerase activity in human T-lymphocyte development and activation. J Exp Med 1996; 183(6): 2471-9.

38. Ornish D., Lin J., Daubenmier J., et al. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol 2008; 9(11):1048-57.

39. Eitsuka T., Nakagawa K., Suzuki T., Miyazawa T. Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: a dual mechanism approach. Biochim Biophys Acta 2005; 1737(1): 1-0.

40. Belenkov YN, Mareev VY, Arutyunov GP, et al. Consensus of experts on the role of ethyl esters of n-3 polyunsaturated fatty acids 90% for the treatment and prevention of heart failure. Serdechnaya Nedostatochnost' 2011; 12 (4): 250-23. Russian (Беленков Ю.Н., Мареев В.Ю., Арутюнов Г.П., и др. Согласованное мнение экспертов о роли этиловых эфиров n-3 полиненасыщенных жирных кислот 90% для лечения и профилактики ХСН. Сердечная Недостаточность 2011; 12(4): 250-23).

41. 2013 ESC/ESH guidelines for the management of arterial hypertension. J Hypertension 2013; 31(7): 1281-357.


For citation:


Drapkina O.M., Shepel' R.N. OMEGA-3 FATTY ACIDS AND AGE-RELATED DISEASES: REALITIES AND PROSPECTS. Rational Pharmacotherapy in Cardiology. 2015;11(3):309-316. (In Russ.) https://doi.org/10.20996/1819-6446-2015-11-3-309-316

Views: 643


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)