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EFFECT OF BETA-BLOCKERS ON BLOOD PRESSURE, PERIOPERATIVE COMPLICATIONS AND HOSPITAL STAY DURATION IN PATIENTS WITH INTERMEDIATE RISK OF CARDIOVASCULAR COMPLICATIONS AFTER ROUTINE CHOLECYSTECTOMY: AN OPEN COMPARATIVE RANDOMIZED STUDY

https://doi.org/10.20996/1819-6446-2010-6-5-667-672

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Abstract

Background. More than 100 million adults are exposed to noncardiac surgical interventions every year worldwide, and cardiovascular complications happen in 500 000 - 900 000 patients.

Aim. To evaluate the efficacy and safety of beta-blocker bisoprolol in the perioperative period in hypertensive patients during routine laparoscopic cholecystectomy.

Material and Methods. Hypertensive patients (n=123) scheduled for laparoscopic cholecystectomy were examined. Patients were randomized into 2 groups. Patients of group 1 (n=57) received preoperatively bisoprolol, and patients of group 2 (n=66) had a correction of previously received antihypertensive therapy without beta-blockers addition. Patient examination included traditional preoperative tests as well as ambulatory blood pressure monitoring and echocardiography.

Results. Heart rate was significantly lower in group 1 at admission (66.1±6.9 min-1) and before surgery (61.3±6.1 min-1) than in group 2 (74,5±8,2 and 73,9±7,0 min-1, respectively, p<0,001 for both periods). The preoperative use of bisoprolol in hypertensive patients reduced the hemodynamic stress manifestations. Heart rate was significantly lower in patients of group 1 during intubation (p<0,001) as well as systolic blood pressure was lower during the carboxiperitoneum (p<0,05) and at the end of surgical procedure (p<0,05) compared with patients of group 2. Perioperative complications were registered in 11 (19.3%) patients of group 1 and 25 (37.9%) patients of group 2.

Conclusion. The preoperative (endoscopic cholecystectomy) use of beta-blocker bisoprolol in hypertensive patients reduces hemodynamic manifestations of stress, hospital stay duration and has a good safety profile.

About the Authors

O. L. Barbarash
Kemerovo State Medical Academy, Research Institute for Complex Problems of Cardiovascular Disease, Siberian Branch of Russian Academy of Medical Sciences
Russian Federation

Oktyabrskiy pr. 22, Kemerovo, 650061 

Sosnovyj bulv. 6, Kemerovo, 650002



R. V. Repnikova
Kemerovo State Medical Academy
Russian Federation
Oktyabrskiy pr. 22, Kemerovo, 650061


T. V. Shoforus
Kemerovo Regional Clinical Hospital
Russian Federation
Oktyabrskiy pr. 22, Kemerovo, 650061


O. I. Golofaeva
Kemerovo State Medical Academy
Russian Federation
Oktyabrskiy pr. 22, Kemerovo, 650061


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For citation:


Barbarash O.L., Repnikova R.V., Shoforus T.V., Golofaeva O.I. EFFECT OF BETA-BLOCKERS ON BLOOD PRESSURE, PERIOPERATIVE COMPLICATIONS AND HOSPITAL STAY DURATION IN PATIENTS WITH INTERMEDIATE RISK OF CARDIOVASCULAR COMPLICATIONS AFTER ROUTINE CHOLECYSTECTOMY: AN OPEN COMPARATIVE RANDOMIZED STUDY. Rational Pharmacotherapy in Cardiology. 2010;6(5):667-672. (In Russ.) https://doi.org/10.20996/1819-6446-2010-6-5-667-672

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