EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY
https://doi.org/10.20996/1819-6446-2013-9-4-390-397
Abstract
Aim. To study the morphological features of loose fibrous connective tissue (LFCT) and myocardial contractility in patients with mitral valve prolapse before and after magnesium orotate course.
Material and methods. Patients (n=59) with mitral valve prolapse and the phenotype of undifferentiated connective tissue dysplasia (UCTD) were included into the study. A comprehensive morphological analysis of skin biopsy samples was performed to assess morphological and functional changes of LFCT. Standard echocardiography with the assessment of mitral flow was performed in all participants at baseline and after 8 weeks of magnesium orotate intake.
Results. According to morphometry increase in proportion of amorphous matrix was found in LFCT sections after 8-week magnesium orotate course compared to baseline (38.6±0.4% and 23.9 ± 0.4%, respectively; p<0.001). According to the echocardiography increase in the end-diastolic (from 4.9±0.04 cm to 5.05±0.03 cm; p<0.05), and the end-sys- tolic (from 2.9±0.04 cm to 3.0±0.03 cm; p<0.01) left ventricular diameters was observed after 8 weeks of treatment as well as improvement of left ventricular diastolic func- tion (E/A raised from 1.42±0.02 to 1.79±0.04; p<0.01).
Conclusion. In patients with mitral valve prolapse and UCTD the 8-week magnesium orotate course led to a significant increase in amorphous part of the matrix, improvement of diffusion ability and architectonics of the connective tissue that determines the improvement of flexibility and extensibility.
About the Authors
A. G. Avtandilov
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
K. M. Dzeranova
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
T. G. Borovaya
Scientific Research Institute of Epidemiology and Microbiology named after N.F. Gamaleya, Moscow
Russian Federation
Russian Federation
L. V. Didenko
Scientific Research Institute of Epidemiology and Microbiology named after N.F. Gamaleya, Moscow
Russian Federation
Russian Federation
References
1. Baker P., Bansal G., Boudoulas H. et al. Floppy mitral valve chordae tendineae: histopathologic alterations. Hum Pathology 1998; 19(5): 507-512.
2. Barlow J.B. Mitral valve billowing and prolapse – an overview. Aust NZJ Med 1992; 22 (Suppl 5): 541-549.
3. Belyaeva L.M.,. Khrustaleva E.K. Cardiovascular disease in children and adolescents: A practical guide. Minsk: Vysheyshaya shkola; 2003. Russian (Беляева Л.М.,. Хрусталева Е.К. Сердечно-сосудистые заболевания у детей и подростков: Практическое руководство. Минск: Вышэйшая школа; 2003).
4. Klemenov A.V. The primary mitral valve prolapse. M.: Interika; 2006. Russian (Клеменов А.В. Первичный пролапс митрального клапана. М.: Интерика; 2006).
5. Lichodziejewska B, Klos J, Rezler J. Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation. Am J Cardiol 1997; 76(6):768-772.
6. Pedersen H.D, Mow T. Hypomagnesemia and mitral valve prolapse in Cavalier King Charles spaniels. Zentralbl Veterinarmed A 1998; 45(10):607-614.
7. Kitlinski M, Konduracka E, Piwowarska. Evaluation of magnesium cation levels in serum of patients with mitrale valve prolapse syndrome. Folia Med Cracov 2000; 41(3-4):17-24
8. Surakova T.V., Zhidomorov N.Yu., Grishina T.R., i dr. Effect of magnesium orotate on the regeneration of the skin. Russkiy Meditsinskiy Zhurnal 2012;20 :(11) :575-581. Russian (Суракова Т.В., Жидоморов Н.Ю., Гришина Т.Р., и др. Влияние оротата магния на регенерацию кожи. Русский Медицинский Журнал 2012;20 :(11) :575-581).
9. Basargina E.N. Connective tissue dysplasia syndrome heart disease in children. Voprosy Sovremennoy Pediatrii 2008;1 (7): 1-4. Russian (Басаргина Е.Н. Синдром дисплазии соединительной ткани сердца у детей. Вопросы Современной Педиатрии 2008;1 (7): 1-4).
10. Domnitskaya T.M., D"yachenko A.V., Kupriyanova O.O., Domnitskiy M.V. The clinical significance of the use of magnesium orotate in adolescents with connective tissue dysplasia syndrome of heart. Kardiologiia 2005;45(3):76-81. Russian (Домницкая Т.М., Дъяченко А.В., Куприянова О.О., Домницкий М.В. Клиническое значение применения магния оротата у подростков с синдромом дисплазии соединительной ткани сердца. Кардиология 2005;45(3):76-81).
11. Rozendorff K. Fundamentals of Cardiology. Principles and Practice. 2nd ed. Lviv: Meditsina svitu; 2007. Russian (Розендорфф К. Основы кардиологии. Принципы и практика. 2-е изд. Львов: Медицина свиту; 2007).
12. Patuchenko O.Yu., Hloponin P.A. Process of the cardiomyogenesis in the human embryonic period.Morphology 2003; (1): 50-54. Russian (Патюченко О. Ю. Хлопонин П.А. Процессы кардиомиогенеза в зародышевом периоде развития человека. Морфология 2003; (1): 50-54)
13. Bratus' V.V., Gavrish A.S. Structure and function of the cardiovascular system. Kiev: Morion; 2008. Russian (Братусь В.В., Гавриш А.С. Структура и функции сердечно-сосудистой системы. Киев: Морион; 2008).
14. Kovalenko V.N. Guidelines for cardiology. Kiev: Morion; 2008. Russian (Коваленко В.Н. Руководство по кардиологии. Киев: Морион; 2008).
15. Cole W., Chan D., Hiskey A. et al. Collagen composition of normal and mixomatous human mitral heart valves. Biochtm J 1984; 219(2):451-460.
16. Avtandilov A.G. Manizer E.D. Mitral valve prolapse and its complications. Diagnosis, treatment, examination. Moscow: Novik; 2009. Russian (Автандилов А.Г. Манизер Е.Д. Пролапс митрального клапана и его осложнения. Диагностика, лечение, экспертиза. Руководство. М.: Новик; 2009).
17. Akatova E. V., Martynov A.I., Nikolin O.P. results long-term treatment of magnesium orotate patients with mitral valve prolapse. Cardiovascular Therapy and Prevention 2012; (3): 30-5. Russian (Акатова Е. В., Мартынов А.И., Николин О. П. Результаты длительной терапии оротатом магния па- циентов с пролапсом митрального клапана. Кардиоваскулярная Терапия и Профилактика 2012; 3: 30-5).
18. Disse S., Abergei E., Derrebi A. et al. Mapping of the first locus for autosomal dominant myxomatous mitral valve prolapse to chromosome 16p11.2 – p.12.1. Am J Hum Genet 1999;65(5):1242-51.
19. Elin R.J. Overview of problems in the assessment of magnesium salts. Magnesium in cellular processes and medicine. Basel: Karger; 1977.
20. Durlach J., Durlach V.,Rayssiguier Y. et al. Magnesium and blood pressure. Magnes Res 1992;5:147-53.
21. Na L.L., Davies S.E. Ameen H. Intracellular free magnesium levels in vascular smooth muscle and striated muscle cells of the spontaneonesly hypertensive rat. Metabolism 1992; 41:772-7.
22. Dzeranova K. M., Avtandilov A.G., Vertkina N.V. The influence of drugs on the physical performance of magnesium in young people with mitral valve prolapse: Results of comparative study. Rational Pharmacother Card 2012; 8(6): 752-5. Russian (Дзеранова К. М., Автандилов А.Г., Верткина Н.В. Влияние препаратов магния на физическую работоспособность у молодых людей с пролапсом мит- рального клапана: результаты несравнительного исследования. Рациональная Фармакотерапия в Кардиологии 2012; 8(6): 752-5).
23. Zemtsovskiy E.V. Dysplastic phenotypes. Dysplastic heart. Analytical Review. St. Petersburg: Ol'ga; 2007. Russian (Земцовский Э.В. Диспластические фенотипы. Диспластическое сердце. Аналитический обзор. СПб.: Ольга; 2007).
24. National guidelines for the diagnosis and treatment of inherited disorders of connective tissue. Cardiovascular Therapy and Prevention 2009; 8(6) suppl 5:1-24. Russian (Национальные рекомендации по диагностике и лечению наследственных нарушений соединительной ткани. Кардиоваскулярная Терапия и Профилактика 2009; 8(6) приложение 5:1-24).
25. Volkova O.V., Eletskiy Yu.K. Fundamentals of histology and histological techniques. Moscow: Meditsina; 1982. Russian (Волкова О.В., Елецкий Ю.К. Основы гистологии и гистологической техники. М.: Медицина; 1982).
26. Avtandilova G.G. Morphometry in pathology. Moscow: Meditsina; 1973. Russian (Автандилова Г.Г. Морфометрия в патологии. М.:Медицина; 1973).
27. Pirs E. Histochemistry. Moscow: IL; 1962. Russian (Пирс Э. Гистохимия. М.: ИЛ; 1962).
28. Gerkhardt F. Methods of bacteriology. Volume 1. Moscow:Mir;1984. Russian (Герхардт Ф. Методы бактериологии. Том 1. М.:Мир;1984).
29. Richard A. Reinhart, Steven K. Broste et al Relation between Magnesium and Potassium Concentrations in Myocardium, Skeletal Muscle and Mononuclear Blood Cells. Clinical chemistry 1992;38(12):2444-8.
Review
For citations:
Avtandilov A.G., Dzeranova K.M., Borovaya T.G., Didenko L.V. EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY. Rational Pharmacotherapy in Cardiology. 2013;9(4):390-397. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-4-390-397
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