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LEFT VENTRICULAR CLOT LYSIS DUE TO COMBINED ANTICOAGULANT THERAPY WITH WARFARIN AND FRAXIPARINE IN PATIENT WITH DILATED CARDIOMYOPATHY AND CHRONIC HEART FAILURE. THE CLINICAL CASE

https://doi.org/10.20996/1819-6446-2011-7-4-473-476

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Abstract

Clinical case demonstrating the possibility of the left ventricle clot lysis due to combined anticoagulant therapy with warfarin and fraxiparine in patient with dilated cardiomyopathy, congestive heart failure and high risk of thromboembolic events is described.

 

About the Authors

O. V. Uskova
N.I. Pirogov Russian National Research Medical University.
Russian Federation


K. O. Sobolev
N.I. Pirogov Russian National Research Medical University.
Russian Federation


G. E. Gendlin
N.I. Pirogov Russian National Research Medical University.
Russian Federation


A. V. Melekhov
N.I. Pirogov Russian National Research Medical University.
Russian Federation


References

1. Doufekias E., Segal A.Z., Kizer J.R. Cardiogenic and Aortogenic Brain Embolism. J Am Coll Cardiol 2008;51(11):1049-59.

2. National guidelines for diagnosis and treatment of chronic heart failure (third revision). Serdechnaja nedostatochnost' 2010; 11(1): 3-62. Russian (Национальные рекомендации ВНОК и ОССН по диагностике и лечению хронической сердечной недостаточности (третий пересмотр). Сердечная недостаточность 2010; 11(1): 3-62).

3. Sacco R.I., Adams R., Albers G. et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack. Stroke 2006; 37: 577-617.

4. Pullicino P.M., Halperin J.L., Thompson J.L. Stroke in patients with heart failure and reduced left ventricular ejection fraction. Neurology 2000; 54: 288-294.

5. Freudenberger R.S., Hellkamp A.S., Halperin J.L. et al. Risk of thromboembolism in heart failure: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Circulation 2007; 115: 2637-2641.

6. Dries D.L., Rosenberg Y.D., Waclawiw M.A., Domanski M.J. Ejection fraction and risk of thromboembolic events in patients with systolic dysfunction and sinus rhythm: evidence for gender differences in the studies of left ventricular dysfunction trials. J Am Coll Cardiol 1997; 29: 1074-1080.

7. Kudryashova B.A. Oral anticoagulation therapy. Indications for the use of oralanticoagulants based on the recommendations of the All-Russian Association for the Study of thrombosis, hemorrhage and vascular pathology behalf A.A. Schmidt. Serdechnaya Nedostatochnost' 2004;5(1):37-39. Russian (Кудряшова Б.А. Терапия оральными антикоагулянтами. Показания для применения оральных антикоагулянтов: по материалам рекомендаций Всероссийской ассоциации по изучению тромбозов, геморрагий и патологии сосудов им. А.А. Шмидта. Сердечная Недостаточность 2004;5(1):37-39).

8. Antman E.M., Anbe D.T., Armstrong P.W. et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction — executive summary: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). J Am Coll Car-diol 2004; 44: 671-719.

9. Gendlin G.E. The use of anticoagulants in chronic heart failure. Serdechnaya nedostatochnost' 2005; 6(6): 266. Russian (Гендлин Г.Е. Применение антикоагулянтов при хронической сердечной недостаточности. Сердечная недостаточность 2005; 6(6): 266).

10. Zaidi S.M., Al-Khuwaitir T.S., Wani B.A., Alafifi E. Resolution of a large left ventricular thrombus with anticoagulation alone. Saudi Med J, 2005, Sep; 26 (9): 1445-1448.

11. Kawata M., Araki S., Adachi K., Mukai T., Ikoma T. Follow-up observation of a patient with left ventricular thrombus by echocardiography. Kobe J Med Sci 1995; 41(3): 63-70.

12. Storozhakov G.I., Blokhina I.G., Selivanov A.I, Gendlin G.E. Atypical thrombosis of the left ventricle with spontaneous lysis of thrombus in acute myocardial infarction without Q wave. Kardiologiia 1996; 11: 103-104. Russian (Сторожаков Г.И., Блохина И.Г., Селиванов А.И, Гендлин Г.Е. Атипичный тромбоз левого желудочка со спонтанным лизисом тромба в остром периоде инфаркта миокарда без зубца Q. Кардиология 1996; 11: 103-104).

13. Ogata C., Nakatani S., Yamagishi M. Images in cardiology. Fragile left atrial thrombus successfully treated with anticoagulants. Heart 2003; 89: 60.

14. Robles P., Jimenez J.J., Huelmos A.I. Complete lysis of the left ventricular giant thrombus with anticoagulation therapy alone. Clin Cardiol 2009; 32 (7): Е 38-39.

15. Roy A., Naik N., Nagesh C.M., Saxena A. Fatal freely mobile left atrial thrombus: fallout of anticoagulation? J Am Soc Echocardiogr 2009; 22 (7): 863.

16. Suslina Z.A., Fonyakina A.V., editors. Practical cardioneurology. M: IMA PRESS; 2010. Russian (Суслина З.А., Фонякина А.В., редакторы. Практическая кардионеврология. М: ИМА ПРЕСС; 2010).

17. Nielsen V.G., Kirklin J.K., Holman W.L., Steeny B.L. Clot lifespan model analysis of the effects of war-farin thrombus growth and fibrinolysis: role of contact protein and tissue factor initiation. ASAIO J 2009; 55 (1): 33-40.


For citation:


Uskova O.V., Sobolev K.O., Gendlin G.E., Melekhov A.V. LEFT VENTRICULAR CLOT LYSIS DUE TO COMBINED ANTICOAGULANT THERAPY WITH WARFARIN AND FRAXIPARINE IN PATIENT WITH DILATED CARDIOMYOPATHY AND CHRONIC HEART FAILURE. THE CLINICAL CASE. Rational Pharmacotherapy in Cardiology. 2011;7(4):473-476. (In Russ.) https://doi.org/10.20996/1819-6446-2011-7-4-473-476

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