Rational Pharmacotherapy in Cardiology

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Aim. To assess effect of ferrotherapy on course of ischemic heart disease (IHD) associated with mild iron deficiency anemia (IDA) and latent iron deficiency (ID). Material and methods. 80 male patients, coal miners, aged 51±7.9 years, were observed. 28 patients had angina pectoris associated with the mild IDA, 23 patients experienced myocardial infarction accompanied by the mild IDA and 29 patients had angina with latent ID. Latent ID was defined in case of iron plasma level ≤12 µg/l, IDA was diagnosed in case of hemoglobin level <130 mg/l. The minimal hemoglobin level observed in patients was 107g/l. ICD clinical characteristics were compared before and after 3-week iron-based treatment in individualized doses. Results. Latent ID and mild IDA aggravated angina and increased ectopic myocardial activity in patients with IHD. Iron-based therapy with appropriate nutrition reduced angina attacks frequency, duration and intensity, decreased nitroglycerin consumption and increased exercise tolerance. Conclusion. Normalization of haemoglobin level and iron plasma concentration in the mild IDA as well as normalization of iron plasma concentration in ID in patients with IHD reduces ede-ma and dyspnea, decreases heart rate. These effects are provided due to the treatment with elementary iron in individualized course dose, which improves clinical status and minimizes the adverse reactions.

About the Authors

N. S. Belousova
Kemerovo Regional Clinical TB Dispensary
Russian Federation

L. V. Frolova
Anzhero-Sudzhensk Occupational Diseases Center
Russian Federation

G. E. Chernogoryuk
Siberian State Medical University
Russian Federation

L. I. Tyukalova
Siberian State Medical University
Russian Federation


1. Culleton B.F., Manns B.J., Zhang J. et al. Impact of anemia on hospitalization and mortality in older adults. Blood 2006; 107(10): 3841–3846.

2. Luthi J.C., Flanders W.D., Burnier M. et al. Anemia and chronic kidney disease are associated with poor outcomes in heart failure patients. BMC Nephrol 2006; 7: 3.

3. Gorokhova S.G., Atamanova M.A., Muraseeva E.V. The evaluation of iron exchange parameters in patients with coronary atherosclerosis and type 2 diabetes mellitus. Klin Med (Mosk) 2007;85(11):50-4. Russian (Горохова С.Г., Атаманова М.А., Мурасеева Е.В. Оценка показателей обмена железа у больных с коронарным атеросклерозом и сахарным диабетом 2 типа. Клиническая медицина 2007; 11: 50–54).

4. Gorokhova S.G., Atamanova M.A. Heart damage in diseases of the blood. In: Belenkov Yu.N., Oganov R.G., editors. Cardiology. National guidelines. Moscow: GEOTAR Media; 2007. P.1128-1135. Russian (Горохова С.Г., Атаманова М.А. Поражение сердца при заболеваниях крови. В: Беленков Ю.Н., Оганов Р.Г., редакторы. Кардиология. Национальное руководство. М.: Гэотар–Медиа; 2007. С.1128-1135).

5. Ziubina L.Iu., Tret'iakov S.V., Loseva M.I., Shpagina L.A. Clinical and functional cardiac characteristics in iron-deficiency anemia. Ter Arkh 2002;74(6):66-9. Russian (Зюбина Л.Ю., Третьякова С.В., Лосева М.И., Шпагина Л.А. Клинико-функциональная характеристика сердца при железодефицитной анемии. Терапевтический архив 2002; 74(6): 66–69).

6. Cavusoglu E., Chopra V., Gupta A. et al. Usefulness of anemia in men as an independent predictor of two-year cardiovascular outcome in patients presenting with acute coronary syndrome. Am J Cardiol 2006; 98(5): 580–584.

7. Assessing Iron Status of Population. Second Edition, including Literature Review. Geneva: WHO; 2007. Available on:

8. How to diagnose diastolic heart failure. European Study Group on Diastolic Heart Failure. Eur Heart J 1998l;19(7):990-1003.

9. Enright P.L., Sherrill D.L. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 1998;158(5 Pt 1):1384-7.

10. Национальные рекомендации по диагностике и лечению стабильной стенокардии. Кардиоваскулярная терапия и профилактика 2008; 7(6) Приложение 4: 1-45.

11. Salonen J.T., Nyyssönen K., Korpela H. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992;86(3):803-11.

12. Worldwide prevalence of anemia 1993-2005. WHO Global Database on Anemia (Распространенность анемии в мире 1993-2005)/Под ред. Benoist B., McLean E., Egil I., Cogswell M. — ВОЗ. Женева. — 2008. — 40с.

13. Vorob'ev P.A. Anemia in clinical practice. Moscow: N'yudiamed; 2001. Russian (Воробьев П.А. Анемический синдром в клинической практике. М.: Ньюдиамед; 2001).

14. Ryabykina G.V., Sobolev A.V. Heart rate variability. Moscow: Overley; 2001. Russian (Рябыкина Г.В., Соболев А.В. Вариабельность ритма сердца. М.: Оверлей; 2001).

15. Chazov E.I., Chazova I.E., editors. Guidelines For hypertension. Moscow: Media Medica; 2005. Russian (Чазов Е.И., Чазова И.Е., редакторы. Руководство по артериальной гипертонии М.: Медиа Медика; 2005).

16. Belkov S.A., Avetyan N.G., Abol'yanina N.E. Anemia in patients with chronic heart failure. Voenno-meditsinskiy zhurnal 2006; 327(7): 72. Russian (Белков С.А., Аветян Н.Г., Абольянина Н.Е. Анемический синдром у больных с хронической сердечной недостаточностью. Военно-медицинский журнал 2006; 327(7): 72).

17. Volkov V.S., Kirilenko N.P. State of the cardiovascular system in patients with iron deficiency anemia: (According to the 8-year observations). Gematologiya i transfuziologiya 1996;4:12–15. Russian (Волков В.С., Кириленко Н.П. Состояние сердечно-сосудистой системы у больных железодефицитной анемией: (По данным 8-летних наблюдений). Гематология и трансфузиология 1996;4:12–15).

18. Volkov V.S., Kirilenko N.P. Changes in the ECG at rest and during physical exertion in patients with iron-deficiency anemia. Klin Med (Mosk). 1986 May;64(5):64-8. Russian (Волков В.С., Кириленко Н.П. Об изменениях ЭКГ в покое и во время физической нагрузки у больных железодефицитной анемией. Клиническая медицина 1986;5:64–68).

19. De Valk B., Marx J.J. Iron, Atherosclerosis, and ischemic heart disease. Arch Intern Med. 1999;159(14):1542-8.

20. Shilov A.M., Mel'nik M.V., Sarycheva A.A. Anemia in heart failure. Russkiy med-itsinskiy zhurnal 2003; 11(9):545–547. Russian (Шилов А.М., Мельник М.В., Сарычева А.А. Анемии при сердечной недостаточности. Русский медицинский журнал 2003; 11(9):545–547).

21. Goodnough LT, Bach RG. Anemia, Transfusion, and Mortality. N Engl J Med 2001;345(17):1272-4.

22. Singla I., Zahid M., Good C.B. et al. Impact of blood transfusions in patients presenting with anemia and suspected acute coronary syndrome. Am J Car-diol 2007;99(8):1119-21.

23. Martynov A.I., Gorokhovskaya G.N., Soboleva V.V. Five-year experience with the drug Sorbifer durules the treatment of iron deficiency conditions. Russkiy meditsinskiy zhurnal 2002; 10(28): 1304–7. Russian (Мартынов А.И., Гороховская Г.Н., Соболева В.В. Пятилетний опыт использования препарата сорбифер дурулес при лечении железодефицитных состояний. Русский медицинский журнал 2002; 10(28): 1304–7).

24. Gorokhovskaya G.N., Ponomarenko O.P., Parfenova E.S. State of the cardiovascular system in iron deficiency anemia. Kremlevskaya meditsina, Klinicheskiy vestnik 1998;2:34–37. Russian (Гороховская Г.Н., Пономаренко О.П., Парфенова Е.С. Состояние сердечно-сосудистой системы при железодефицитных ане-миях. Кремлевская медицина, Клинический вестник 1998;2:34–37).

25. Bogdanova O.M., Pashchenko I.G. Comparative efficacy of treatment of iron deficiency anemia in patients with elderlymedication salt of iron hydroxide-polymaltose complex of iron. Gematologiya i transfuziologiya 2004; 49(1):115–120. Russian (Богданова О.М., Пащенко И.Г. Сравнительная оценка эффективности лечения железодефицитной анемии у больных пожилого и старческого возраста препаратами солевого железа и гидроксидполимальтозного комплекса железа. Гематология и трансфузиология 2004; 49(1):115–120).

For citation:

Belousova N.S., Frolova L.V., Chernogoryuk G.E., Tyukalova L.I. EFFECT OF FERROTHERAPY ON COURSE OF ISCHEMIC HEART DISEASE ASSOCIATED WITH MILD IRON DEFICIENCY IN MEN. Rational Pharmacotherapy in Cardiology. 2011;7(4):457-462. (In Russ.)

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