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COMPARISON OF CLINICAL EFFICACY OF ORIGINAL BISOPROLOL AND ITS GENERIC DRUG IN PATIENTS WITH STABLE ANGINA AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE

https://doi.org/10.20996/1819-6446-2010-6-4-497-501

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Abstract

Aim. To compare clinical efficacy and effect on endothelium function of original bisoprolol and its generic in patients with stable angina and concomitant chronic obstructive pulmonary disease (COPD).

Material and methods. Patients with the stable angina and COPD (n=72) were included into the study. Patients were randomized for treatment with the original bisoprolol (1st group; n=36) and the generic bisoprolol (2nd group; n=36). Endothelium-dependent vasodilation test, office measurement of heart rate in 2 hours after bisoprolol taking, 24-hour electrocardiogram-monitoring, evaluation of respiratory function, level of nitrogen oxide metabolites were are performed initially and in 12 weeks.

Results. Antihypertensive and antiischemic effects were observed in both groups in 12 weeks of treatment. However significant improvements of endothelial function were detected only in patients of the 1st group. Heart rate reduction from 98.6±2.5 to 58.6±3.5 bt/min (р<0.001) was found with the 24 hour electrocardiogram-monitoring after 12 weeks of therapy in the 1st group and from 96.9±4.9 to 66.3±5.6 bt/min (р<0.001) in the 2nd group. Reached heart rate level in the 1st group was less than this in the 2nd group (р<0.001). Negative changes of respiratory function were absent in the both groups in 4 weeks of treatment, however significant reduction of respiratory indices was registered in the 2nd group after 12 weeks of treatment.

Conclusion. Original bisoprolol is more effective and tolerable than generic bisoprolol in patients with the stable angina and concomitant COPD.

About the Authors

N. Yu. Grigorieva
Nizhny Novgorod State Medical Academy
Russian Federation
Minina pl. 10/1, Nizhny Novgorod, 603005


E. G. Sharabrin
Nizhny Novgorod State Medical Academy
Russian Federation
Minina pl. 10/1, Nizhny Novgorod, 603005


A. N. Kuznetsov
Nizhny Novgorod State Medical Academy
Russian Federation
Minina pl. 10/1, Nizhny Novgorod, 603005


References

1. Fox K., Garcia M.A., Ardissino D. et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J 2006; 27(11):1341-81.

2. Freemantle N., Cleland J., Young P. et al. Beta blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 1999; 318(7200):1730-7.

3. MERIT-HF Study Group. Effects of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomized International Trial in CongestiveHeart Failure (MERIT-HF). Lancet 1999; 353(9169):2001-7.

4. Flather M.D., Shibata M.C., Coats A.J. et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26(3):215-25.

5. Willenheimer R., van Veldhuisen D.J., Silke В. et al. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation 2005;112(16):2426-35.

6. Furberg C., HerringtonD., Psaty B.M. Class effect.Are drugs within a class interchangeable? Lancet 1999;354:1202-4.

7. Диагностика и лечение стабильной стенокардии: Российские рекомендации (второй пересмотр). Всероссийское научное общество кардиологов. Кардиоваскулярная терапия и профилактика 2008;7(6 Приложение 4):1-32.

8. Global Initiative for Chronic Obstructive Lung Diseases (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. Last updated 2009. Available on http://www.goldcopd.com/download.asp?intId=552

9. Celermajer D.S., Sorensen K.E., Gooch V.M. et al. Non-invasive detection of endothelial dysfunction on children and adults at risk of athe￾rosclerosis. Lancet 1992;340(8828):1111-5.

10. Метельская В.А., ГумановаН.Г. Скрининг метод определения уровня метаболитов оксида азота в сыворотке крови человека. Клиническая лабораторная диагностика 2005;(6):15-8.

11. Голиков П.П., Николаева Н.Ю., Гавриленко И.А. и др. Оксид азота и перекисное окисление липидов как факторы эндогенной интоксикации при неотложных состояниях. Патологическая физиология и экспериментальна терапия 2000;(2): 6-8.

12. Гринхальх Т. Основы доказательной медицины. М: «ГеотарМед»; 2004.

13. Chatterjee S.S. The cardioselective and hypotensive effects of bisoprolol in hypertensive asthmatics. J Cardiovasc Pharmacol 1986;8 Suppl 11:S74-7.

14. Harting J., Becker K.H., Bergmann R. et al. Pharmacodynamic profile of the selective beta 1-adrenoceptor antagonist bisoprolol. Arzneimittelforschung. 1986;36(2):200-8.

15. Зарубина Е.Г., Мишина Е.А., Осадчук М.А. Роль эндотелиальной дисфункции в патогенезе сочетанных сердечно-легочных заболеваний. Клиническая медицина 2006;84(5):31-4.

16. Задионченко В.С., Нестеренко О.И., Погонченкова И.В. и др. Коррекция эндотелиальной дисфункции у больных хроническим легочным сердцем ингибиторами ангиотензинпревращающего фермента. Российский кардиологический журнал 2006;(S):53- 9.

17. Sin D.D., Man S.F. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003;107(11):1514-9.

18. Шумилина М.В. Комплексная ультразвуковая диагностика патологии периферических сосудов. Учебно-методическое руководство. М.: НЦССХ им. А. Н. Бакулева РАМН; 2007.


For citation:


Grigorieva N.Yu., Sharabrin E.G., Kuznetsov A.N. COMPARISON OF CLINICAL EFFICACY OF ORIGINAL BISOPROLOL AND ITS GENERIC DRUG IN PATIENTS WITH STABLE ANGINA AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Rational Pharmacotherapy in Cardiology. 2010;6(4):497-501. (In Russ.) https://doi.org/10.20996/1819-6446-2010-6-4-497-501

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