COMPARISON OF ENALAPRIL AND PERINDOPRIL IN PATIENTS WITH ARTERIAL HYPERTENSION AND LEFT VENTRICLE SYSTOLIC DYSFUNCTION
https://doi.org/10.20996/1819-6446-2010-6-2-179-184
Abstract
Aim. To compare efficacy of enalapril and perindopril in patients with arterial hypertension (HT) and left ventricle systolic dysfunction.
Material and methods. Patients (n=51) with HT and left ventricle systolic dysfunction (ejection fraction<45%) were included in the prospective open randomized comparative study. Patients were randomized into 2 groups of therapy with enalapril 10-20 mg BID (n=25) or with perindopril 4-8 mg OD (n=26). Hydrochlorothiazide (12,5-25 mg OD) was added in case of ineffective therapy. Routine clinical examination, ambulatory blood pressure (BP) monitoring, an electrocardiogram, an echocardiography were performed in all patients.
Results. The 24-hour and night antihypertensive effect of enalapril was more prominent than this of perindopril. Target BP level was reached in 21 patients (84%) of enalapril group and in 20 patients (76,9%) of perindopril group. 8 (30,8%) patients of perindopril group did not reach night target BP level vs 3 (12%) patients of enalapril group. Similar improvement of the left ventricle systolic function was observed in both groups.
Conclusion. Enalapril and perindopril demonstrated comparable antihypertensive and cardioprotective effect.
About the Authors
Yu. I. Grinshtein
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
O. L. Barbarash
Kemerovo State Medical Academy
Russian Federation
Voroshilova ul. 22A, Kemerovo, 650023
Russian Federation
Voroshilova ul. 22A, Kemerovo, 650023
D. A. Yakhontov
Novosibirsk State Medical University
Russian Federation
Krasny Prospect 52, Novosibirsk, 630091
Russian Federation
Krasny Prospect 52, Novosibirsk, 630091
A. E. Popelysheva
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
V. V. Shabalin
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
N. B. Osetrova
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
Russian Federation
Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022
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Review
For citations:
Grinshtein Yu.I., Barbarash O.L., Yakhontov D.A., Popelysheva A.E., Shabalin V.V., Osetrova N.B. COMPARISON OF ENALAPRIL AND PERINDOPRIL IN PATIENTS WITH ARTERIAL HYPERTENSION AND LEFT VENTRICLE SYSTOLIC DYSFUNCTION. Rational Pharmacotherapy in Cardiology. 2010;6(2):179-184. (In Russ.) https://doi.org/10.20996/1819-6446-2010-6-2-179-184
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