Rational Pharmacotherapy in Cardiology

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Aim. To study influence of beta-blockers carvedilol and metoprolol tartrate on platelet aggregative ability, evaluated by three different methods, in patients with acute ST segment elevation myocardial infarction (STEMI).

Material and methods. A total of 86 men aged 36-68 with uncomplicated STEMI were included into an open, comparative, randomized study. Patients were randomized into two groups of beta-blocker treatments. Patients (n=44) of the first group received carvedilol; patients (n=42) of the second one - metoprolol tartrate. Parameters of platelet hemostasis: the maximum amplitude and rate of platelet aggregation induced by ADP, ristomycin and collagen; mean platelet volume (MPV); serum level of soluble CD40 ligand (sCD40L) were evaluated on the 2nd and 24th day after STEMI onset.

Results. In patients with uncomplicated STEMI carvedilol more prominently reduced in vitro platelet aggregation induced by adenozin-5'-diphosphate in high concentration, ristomycin and collagen than metoprolol tartrate. Сarvedilol also more significantly decreased MPV in comparison with metoprolol tartrate. However, effect of both carvedilol and metoprolol tartrate on the level of another platelet aggregation marker - sCD40L was comparable.

Conclusion. Carvedilol and metoprolol tartrate have similar effect on platelet aggregation though in according to some tests carvedilol more prominently reduces platelet aggre￾gation than metoprolol tartrate.

About the Authors

A. N. Zakirova
Bashkir State Medical University
Russian Federation
Lenina ul. 3, Ufa, 450000

B. N. Garifullin
City Hospital №18, Ufa
Russian Federation
Blukchera ul. 3, Ufa, 450009

F. S. Zarudij
Bashkir State Medical University
Russian Federation
Lenina ul. 3, Ufa, 450000

N. E. Zakirova
Bashkir State Medical University
Russian Federation
Lenina ul. 3, Ufa, 450000


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For citation:

Zakirova A.N., Garifullin B.N., Zarudij F.S., Zakirova N.E. EFFECTS OF CARVEDILOL ON PLATELET AGGREGATION IN MEN WITH ST-ELEVATION ACUTE MYOCARDIAL INFARCTION. Rational Pharmacotherapy in Cardiology. 2010;6(2):149-159. (In Russ.)

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