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Currently, a greater emphasis is placed on the search for additional biomarkers of chronic heart failure (CHF). Galectin-3, a marker of fibrosis and inflammation, has shown himself as a biomarker of CHF in many studies, but the dynamics of its levels in patients with concomitant diabetes mellitus (DM) type 2 is not well-studied.

Aim. To identify diagnostic significance of galectin-3 plasma level evaluation and its correlations with echocardiographic criteria for patients with CHF and DM type 2.

Material and methods. The study included 33 patients with ischemic CHF (all patients had a history of myocardial infarction) and DM type 2. The patients were divided into two groups according to the left ventricle (LV) ejection fraction (EF): a group with CHF and preserved ejection fraction (PEF) (EF≥50%) and with CHF and reduced ejection fraction (EF<50%). Patients underwent clinical laboratory tests and Doppler echocardiography; moreover, the levels of brain natriuretic peptide (BNP) and galeсtin-3 were measured.

Results. The mean level of galectin-3 in blood plasma in the group with CHF and PEF was significantly higher than in the group with CHF and reduced EF (p=0.007). In the group with CHF and PEF a positive correlation between the level of galectin-3 and diastolic LV function E/E' was found (r=0.620, p=0.01). A significant correlation between galectin-3 level and LV systolic function was stated in the group with reduced EF (r=0.53; p<0.05), while in the group with PEF, the correlation was not significant (p=0.225). In the group of patients with reduced EF a negative correlation between galectin-3 and the volume of left atrium was revealed (r=-0.53; p<0.05).

Conclusion. Galectin-3 can be used as a diagnostic biomarker primarily in patients with CHF and PEF.

About the Authors

A. A. Snetkova
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation

Delegatskaya ul. 20/1, Moscow, 127473 Russia

N. Yu. Timofeeva
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation

Delegatskaya ul. 20/1, Moscow, 127473 Russia

V. S. Zadionchenko
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation

Delegatskaya ul. 20/1, Moscow, 127473 Russia


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For citation:

Snetkova A.A., Timofeeva N.Yu., Zadionchenko V.S. DIAGNOSTIC VALUE OF GALECTIN-3 LEVEL IN PATIENTS WITH CHRONIC HEART FAILURE AND TYPE 2 DIABETES. Rational Pharmacotherapy in Cardiology. 2015;11(2):139-143. (In Russ.)

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