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ANTIHYPERTENSIVE EFFICACY AND VASOPROTECTIVE PROPERTIES OF A NEW COMBINATION OF BETA-BLOCKER, BISOPROLOL (2,5/5 MG) AND DIURETIC, HYDROCHLOROTHIAZIDE (6,25 MG)

https://doi.org/10.20996/1819-6446-2010-6-1-48-53

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Abstract

Aim. To study influence of the fixed bisoprolol (BIS) + hydrochlorothiazide (HCT) combination on blood pressure (BP) level and a blood flow in middle cerebral artery in patients with a arterial hypertension (HT), 1 degree.

Material and methods. 18 patients with HT 1 degree (7 men, 11 women; age 50,1±5,7 y.o.) were included in the non-comparative open study. All patients received a com￾bination of selective beta1-adrenoblocker (BIS 2.5-5 mg) and diuretic (HCT 6,25 mg). Initially and in 12 weeks of the treatment all patients had a standard clinical examination, ambulatory BP monitoring, ultrasonography of mesencephalic arteries for evaluation of the cerebrovascular blood flow reactivity.

Results. The target BP level (<140/90 mm Hg) in 12 weeks of the treatment (12 patients received BIS 5 mg/HCT 6,25 mg, 6 patients - BIS 2,5 mg/HCT 6,25 mg) was reached in 100% of patients. Besides, significant increase in cerebral blood flow reactivity was found in tests with hyper- and hypoventilation.

Conclusion. The fixed BIS/HCT combination has high antihypertensive and vasoprotective efficacy.

About the Authors

O. D. Ostroumova
Moscow State University of Medicine and Dentistry
Russian Federation
Delegatskaya ul. 20/1, Moscow, 127473


A. G. Sazonova
Moscow State University of Medicine and Dentistry
Russian Federation
Delegatskaya ul. 20/1, Moscow, 127473


K. U. Reznikova
Moscow State University of Medicine and Dentistry
Russian Federation
Delegatskaya ul. 20/1, Moscow, 127473


A. V. Srednjakov
Moscow State University of Medicine and Dentistry
Russian Federation
Delegatskaya ul. 20/1, Moscow, 127473


E. A. Smolyarchuk
Moscow State University of Medicine and Dentistry
Russian Federation
Delegatskaya ul. 20/1, Moscow, 127473


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For citation:


Ostroumova O.D., Sazonova A.G., Reznikova K.U., Srednjakov A.V., Smolyarchuk E.A. ANTIHYPERTENSIVE EFFICACY AND VASOPROTECTIVE PROPERTIES OF A NEW COMBINATION OF BETA-BLOCKER, BISOPROLOL (2,5/5 MG) AND DIURETIC, HYDROCHLOROTHIAZIDE (6,25 MG). Rational Pharmacotherapy in Cardiology. 2010;6(1):48-53. (In Russ.) https://doi.org/10.20996/1819-6446-2010-6-1-48-53

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