Rational Pharmacotherapy in Cardiology

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Results of combined therapy of gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hypercholesterolemia (HCE) with statins and ursodeoxycholic acid (UDCA) are analyzed. In GSD statin therapy was often accompanied with reduction of bile lithogenicity but did not always accelerate stone litholysis under their combination with UDCA. Statin induced liver injuries are often observed in NAFLD and NASH, adjuvant UDCA therapy shown positive effect on inflammatory and histological liver parameters in these diseases. Serum lipid levels in patients with HCE were reduced most effectively with statin combined with UDCA. Combined therapy with statin and UDCA is recommended in patient with HCE and chronic liver diseases.

About the Authors

I. N. Grigorieva
Research Institute for Therapy, Siberian branch of Russian Academy of Medical Sciences, Novosibirsk State Medical University
Russian Federation

B.Bogatkova ul. 175/1, Novosibirsk, 630089

Krasnyi prospect 52, Novosibirsk, 630099

Y. M. Pozdnyakov
Moscow Regional Cardiologic Centre
Russian Federation
Frunze ul. 1, Moscow region, Zhukovski, 140180


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For citation:

Grigorieva I.N., Pozdnyakov Yu.M. STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY? Rational Pharmacotherapy in Cardiology. 2009;5(6):51-54. (In Russ.)

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