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SEX CHARACTERISTICS OF THE MICROCIRCULATION IN HEALTHY SUBJECTS AND IN PATIENTS WITH THE FIRST DEGREE ARTERIAL HYPERTENSION

https://doi.org/10.20996/1819-6446-2012-8-6-746-451

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Abstract

Aim. To study the sex characteristics of microcirculation in healthy volunteers and in patients with degree 1 arterial hypertension (HT). Material and methods. Patients (n=71; 34 men and 37 women) with degree 1 HT participated in the study. Besides 28 normotensive men and 41 women were included. The microcirculation study was performed with LAKK-02 analyzer on the palmar surface of the third finger of the right hand. The average values of the microcirculation index, the standard deviation of perfusion fluctuations (σ), the variation coefficient of tissue blood flow (Kv) were evaluated. Results. The microcirculation index in HT men 26.64 (21.00–32.45) perfusion units (p.u.) was significantly higher than this in HT women 20.91 (16.98–24.30) p.u., p=0.031. The variability of microcirculation index was significantly higher in HT patients than this in healthy subjects. Capillary blood flow reserve in healthy women was higher than this in healthy men. Amplitude, reflexing myogenic factor of blood flow regulation was significantly lower in HT men than this in HT women: 13.37 (10.51–16.43) vs 14.69 (11.35–19.13), respectively , p=0.023. Amplitudes, reflecting respiration effects on peripheral blood flow in HT men were significantly higher than these in HT women. Amplitudes, reflecting pulse effect on the tissue perfusion in HT women were significantly higher than these in HT men. Influence of sympathetic adrenergic innervation on the blood flow was higher in healthy men than this in healthy women. Conclusion. Received data suggests the intensification of microcirculation regulation mechanisms in men with HT degree 1. It was found that sympathetic adrenergic effect on the microcirculation regulation was significantly less in healthy women than this in healthy men.

About the Authors

V. I. Podzolkov
I.M.Sechenov First Moscow State Medical University
Russian Federation


L. V. Vasil'eva
I.M.Sechenov First Moscow State Medical University
Russian Federation


V. V. Matveev
I.M.Sechenov First Moscow State Medical University
Russian Federation


N. A. Kolesnichenko
Medical education and clinical research Center n.a. P .V. Mandryka
Russian Federation


References

1. National guidelines for diagnosis and treatment of hypertension (4th revision). Sistemye Gipertenzii 2010; (3):5–26. Russian (Национальные рекомендации по диагностике и лечению артериальной гипертонии (четвертый пересмотр). Системные гипертензии 2010; (3): 5–26).

2. Vitale C., Miceli M. and Rosano G. M. C. Gender-specific characteristics of atherosclerosis in menopausal women: risk factors, clinical course and strategies for prevention. Climacteric 2007; 10(Suppl 2):16–20.

3. Prohorovich E.A., Tkacheva O.N., Adamenko A.N. Gender aspects of arterial hypertension. Spravochnik Poliklinicheskogo Vracha 2003; 5(3): 34–41. Russian (Прохорович Е.А., Ткачева О.Н., Адаменко А.Н. Гендерные аспекты артериальной гипертонии. Справочник Поликлинического Врача 2003; 5(3):34–41).

4. Makolkin V.I., editor. Microcirculation in cardiology. Moscow: Vizart; 2004. Russian (Маколкин В.И., редактор. Микроциркуляция в кардиологии. М.: Визарт; 2004).

5. Bran’ko V.V., Vahlyaev V.D., Kamshilina L.S., Makolkin V.I. Usage of Laser Doppler Flowmetry methodic in cardiology. Rossiyskiy Meditsinskiy Zhurnal 1998; 3: 34–38. Russian (Бранько В. В., Вахляев В. Д., Камшилина Л. С., Маколкин В. И. Применение метода лазерной допплеровской флоуметрии в кардиологии. Российский Медицинский Журнал 1998; (3): 34–38).

6. Podzolkov V.I., Bulatov V.A. Microcirculatory impairment in arterial hypertension: cause, consequence or another one “vicious circle”? Сердце 2008; 4(3): 132–138. Russian (Подзолков В.И., Булатов В.А. Нарушение микроциркуляции при артериальной гипертензии: причина, следствие или еще один «порочный круг»? Сердце 2008;4(3):132–138.).

7. Makolkin V.I., Podzolkov V.I., Pavlov V.I., Samoylenko V.V. Microcirculation in arterial hypertension. Kardilogiia 2003; (5): 60–67. Russian (Маколкин В.И., Подзолков В.И., Павлов В.И., Самойленко В.В. Состояние микроциркуляции при гипертонической болезни. Кардиология 2003; (5): 60–67).

8. Struijker Boudier H.A.J. Hypertension and microcirculation. In: Kaplan N., ed. Hypertension, microcirculation and end organ damage. London: Lippincott Williams & Wilkins: 2002; 49–57.

9. Krupatkin A.I. Laser Doppler Flowmetry of microcirculation. Moscow: Medicina; 2005. Russian (Крупаткин А.И. Лазерная допплеровская флоуметрия микроциркуляции крови. М.: Медицина; 2005).

10. Kozlov V.I. Blood microcirculatory system: clinical and morphological aspects for study. Regionarnoe Krovoobrashchenie i Mikrotsirkulyatsiya 2006; 5(2): 84–101. Russian (Козлов В.И. Система микроциркуляции крови: клинико-морфологические аспекты изучения. Регионарное Кровообращение и Микроциркуляция 2006; 5(2): 84–101).

11. Tihonova I.V., Tankanagh A.V., Kosyakova N.I., Chemeris N.K. Age-specific characteristics of human skin microcirculatory function. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 2005; 91(10): 1132–1136. Russian (Тихонова И. В., Танканаг А. В., Косякова Н. И., Чемерис Н. К. Возрастные особенности функционирования микроциркуляторного русла кожи человека. Российский физиологический журнал имени И. М. Сеченова 2005; 91(10): 1132– 1136).

12. Ovchinnikova O.A. Assessment of gender-specific characteristics of vegetative and vascular regulation of microcirculation by laser Doppler flowmetry. Yaroslavskiy Pedagogicheskiy Vestnik 2010; (3): 52–55. Russian (Овчинникова О.А. Оценка гендерных особенностей вегето-сосудистой регуляции микроциркуляции методом лазерной допплеровской флоуметрии. Ярославский Педагогический Вестник 2010; (3): 52–55.).

13. NPO “Lazma” Computerised laser analyser of microcirculation LAKK-02. Moscow: OOO Nauchnoproizvodstvennoe predpriyatie «LAZMA»; 2006. Russian (НПО «Лазма» Анализатор лазерный микроциркуляции крови компьютеризированный ЛАКК-02 (исполнение 4). М.: ООО Научно-производственное предприятие «ЛАЗМА»; 2006).

14. Kozlov V.I., Mach F.B., Litvin O.A. et al. Laser Doppler Flowmetry method. Moscow: Transonik; 2001. Russian (Козлов В. И., Мач Ф. Б., Литвин О. А. и др. Метод лазерной допплеровской флоуметрии: Пособие для врачей. М.: Трансоник; 2001).

15. Vasilyev A.P., Strelcova N.N., Sekisova M.A., et al. Functional characteristics of microcirculation at patients suffered from arterial hypertension and its prognostic value. Kardiovaskulyarnaya Terapiya i Profilaktika 2011; 10(5): 14–19. Russian (Васильев А.П., Стрельцова Н.Н., Секисова М.А., и др. Функциональные особенности микроциркуляции у больных артериальной гипертонией и их прогностическое значение. Кардиоваскулярная Терапия и Профилактика 2011; 10(5): 14–19.).

16. Kolbasin L.N., Buganov A.A., Mamedov S.I. Microcirculation of healthy emigrants from the Far North. Vestnik Vosstanovitel'noy Meditsiny 2008; 2 (24): 31–35. Russian (Колбасин Л.Н., Буганов А.А., Мамедов С.И. Состояние микроциркуляции у здоровых пришлых жителей Крайнего Севера. Вестник Восстановительной Медицины 2008; 2(24): 31–35.


For citation:


Podzolkov V.I., Vasil'eva L.V., Matveev V.V., Kolesnichenko N.A. SEX CHARACTERISTICS OF THE MICROCIRCULATION IN HEALTHY SUBJECTS AND IN PATIENTS WITH THE FIRST DEGREE ARTERIAL HYPERTENSION. Rational Pharmacotherapy in Cardiology. 2012;8(6):746-451. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-6-746-451

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