Rational Pharmacotherapy in Cardiology

Advanced search


Full Text:


Epicardial fat is hormonally active tissue and has a direct impact on the myocardium state and coronary blood flow. The relationship of epicardial fat size and waist circumference with different clinical and metabolic parameters and coronary atherosclerosis severity in patients with ischemic heart disease is discussed.

About the Authors

O. M. Drapkina
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation

O. N. Korneeva
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation

Yu. S. Drapkina
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation


1. Kannel WB. Sixty years of preventive cardiology: a framingham perspective. Clinical Cardiology 2011; 34 (6): 342–3.

2. Mamedov M.N. Metabolic syndrome – more than the combination of risk factors: principles of diagnosis and treatment. Moscow: Vervag farma; 2006. Russian (Мамедов М.Н. Метаболический синдром — больше, чем сочетание факторов риска: принципы диагностики и лечения. М.: Верваг фарма; 2006)

3. Drapkina O. M. Application of essential phospholipids in the treatment of NASH mixed origin. Consilium medicum 2009; (2): 3–5. Russian (Драпкина О. М. Применение эссенциальных фосфоли- пидов в комплексной терапии стеатогепатита смешанного генеза. Consilium medicum 2009; (2): 3–5).

4. Drapkina O.M., Tutnov D.A. Features of treatment of hypertension in patients with liver disease. Rosssiyskie Meditsinskie Vesti 2008; (3): 43–48. Russian (Драпкина О.М., Тутнов Д.А. Особенности лечения артериальной гипертензии у больных с заболеваниями печени. Росссийские Медицинские Вести 2008; (3): 43–48).

5. Drapkina O.M., Drapkina Yu.S. Fibrosis and renin-angiotensin-aldosterone system. Realities and Perspectives. Arterial Hypertension 2012; (5):449–58. Russian (Драпкина О.М., Драпкина Ю.С. Фиброз и активность ренин-ангиотензин-альдостероновой системы. Реалии и Перспективы. Артериальная Гипертензия 2012; (5):449–58).

6. Juge-Aubry CE, Henrichot E, Meier CA. Adipose tissue: a regulator of inflammation. Best Pract Res Clin Endocrinol Metab 2005; 19 (4): 547–66.

7. Drapkina O. M., Ivashkin V.T. Abdominal pain. Russian Journal of Gastroenterology, Hepatology, Coloproctology 2002;12(4):8–15. Russian (Драпкина О. М., Ивашкин В.Т. Абдоминальный болевой синдром. Российский Журнал Гастроэнтерологии, Гепатологии, Колопроктологии 2002;12(4):8– 15).

8. Brook RD. Obesity, weight loss, and vascular function. Endocrine 2006; 29 (1): 21–5.

9. Montani JP, Carroll JF, Dwyer TM. Ectopic fat storage in heart, blood vessels and kidneys in the patho- genesis of cardiovascular diseases. Int J Obes Relat Metab Disord 2004; 28 (4): 58–65.

10. Moore KL, Persaud TN. The developing human. Clinically oriented embryology. 7th ed. Philadelphia, PA: Saunders; 2003.

11. Malavazos AE, Ermetici F, Cereda E et al. Epicardial fat thickness: relationship with plasma visfatin and plasminogen activator inhibitor-1 levels in visceral obesity. Nutr Metab Cardiovasc Dis 2008; 18 (8): 523–30.

12. Chumakova G.A., Veselovskaya N.G., Kozarenko A.A. Epicardial adipose depots: morphology, diagnosis, clinical significance. Heart 2011; 10 (59): 143–7. Russian (Чумакова Г.А., Веселовская Н.Г., Козаренко А.А. Эпикардиальное жировое депо: морфология, диагностика, клиническое значение. Сердце 2011; 10 (59): 143–7).

13. Iacobellis G, Assael F, Ribaudo MC et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 2003; 11 (2): 304–10.

14. Aydin H, Toprak A, Deyneli O et al. Epicardial Fat Tissue Thickness Correlates With Endothelial Dys- function and Other Cardiovascular Risk Factors in Patients With Metabolic Syndrome. Metab Syndr Relat Disord 2010; 8 (3): 229–34.

15. Iacobellis G, Pistilli D, Gucciardo M et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 2005; 29 (6): 251–5.

16. Silaghi A, Achard V, Paulmyer-Lacroix O et al. Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status. Am J Physiol Endocrinol Metab 2007; 293 (5): 1443–50.

17. Nelson MR, Mookadam F, Thota V. Epicardial Fat: An Additional Measurement for Subclinical Atherosclerosis and Cardiovascular Risk Stratification. J Am Soc Echocardiogr 2011; 24 (3): 339–45.

For citation:

Drapkina O.M., Korneeva O.N., Drapkina Yu.S. EPICARDIAL FAT: A STRIKER OR A SPARE? Rational Pharmacotherapy in Cardiology. 2013;9(3):287-291. (In Russ.)

Views: 713

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)