Preview

Rational Pharmacotherapy in Cardiology

Advanced search

CLINICAL EFFECT OF TESTOSTERONE IN MEN WITH STABLE ANGINA

https://doi.org/10.20996/1819-6446-2009-5-1-37-41

Full Text:

Abstract

Aim. To study efficacy of testosterone undecanoate (TU) therapy in men with stable angina and androgen deficiency.

Material and methods. The serum testosterone level was detected in 247 men (aged 51,6±1,8 y.o.) with stable effort angina. 60 patients with androgen deficiency addition￾ally to basic angina therapy received TU (120-160 mg daily). 54 patients with androgen deficiency (control group) received only basic angina therapy. Dynamics of clinical and ECG manifestations of myocardial ischemia and quality of life (QOL) parameters was studied.

Results. Androgen deficiency is revealed in 114 (46,2%) of patients. Therapy with TU during 3 months resulted in reduction of angina attacks and extent of myocardial ischemia (according to Holter ECG monitoring and stress test) as well as QOL improvement.

Conclusion. Androgen deficiency is observed in 46,2% of men with stable angina. TU increases of antianginal therapy efficacy, improves QOL and is well tolerated. 

About the Authors

A. Ya. Kravchenko
Voronezh State Medical Academy named after N.N. Burdenko
Russian Federation
Studencheskaya ul. 10, Voronezh, 394000


V. M. Provotorov
Voronezh State Medical Academy named after N.N. Burdenko
Russian Federation
Studencheskaya ul. 10, Voronezh, 394000


References

1. Аметов А.С, Верткин А.Л., Моргунов Л.Ю. и др. Возможности коррекции кардиоваскулярной патологии у мужчин с возрастным дефицитом андрогенов (обзор). Тер арх 2007;79(10):50-3.

2. Дедов И.И., Калинченко С.Ю. Возрастной андрогенный дефицит у мужчин. М.: Практическая медицина, 2006.

3. Hak Е., Witteman J.C., de Jong F H. et al. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: The Rotterdam Study. J Clin Endocrinol Metab 2002;87(8):3632-9.

4. Malkin C.J., Pugh P.J., Jones T.H., Channer K.S. Testosterone for secondary prevention in men with ischaemic heart disease? QJM 2003;96(7):521-9.

5. Walker T.C. Use of testosterone propionate and estrogenic substances in treatment of essential hypertension, angina pectoris and peripheral vascular disease. J Clin Endocrinol 1942;2:560-8.

6. Jaffe M.D. Effect of testosterone cypionate on postexercise ST segment depression. Br Heart J 1977;39:1217-22.

7. Wu S.Z., Weng X.Z. Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients. Chin Med J (Engl) 1993;106(6):415–8.

8. Rosano GM, Leonardo F, Pagnotta P, et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 1999;99:1666–70.

9. English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 2000;102:1906–11.

10. Nieschlag E., Swerdloff R., Behre H.M., еt al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. J Androl 2006;27(2):135-7.

11. Аронов Д.М., В.П.Лупанов. Функциональные пробы в кардиологии. М.: МЕДпресс-информ, 2003.

12. Аронов Д.М., Зайцев В.П. Методика оценки качества жизни больных с сердечно-сосудистыми заболеваниями. Кардиология 2002;(5):92- 5.

13. Tostain J.L., Blanc F. Testosterone deficiency: a common, unrecognized syndrome. Nat Clin Pract Urol 2008;5(7):388-96.

14. Pugh P.J. Malkin C.J., Morris P.D. et al. The prevalence of hypogonadism in men with coronary artery disease (abstract). J Am Coll Cardiol. 2003;41(6 Suppl B):344-5.

15. Верткин А.Л., Моргунов Л.Ю., Наумов А.В., и др. Дефицит андрогенов и ассоциированная с ним общесоматическая патология. Фарматека 2008;(9):27-33.

16. Channer K.S., Jones T.H. Cardiovascular effects of testosterone: implications of the “male menopause”? Heart 2003;89:121–2.

17. English KM, Jones RD, Jones TH, et al. Testosterone acts as a coronary vasodilator by a calcium channel antagonist action. J Endocrinol Invest 2002;25:455–8.

18. Hall J, Jones RD, Jones TH, et al. Selective inhibition of L-type Ca2+ channels in A7r5 cells by physiological levels of testosterone. Endocrinology 2006;147(6):2675-80.

19. Верткин А.Л., Калинченко С.Ю., Полупанова Ю.С. и др. Вопросы безопасности терапии андрогенами. РМЖ 2007;15(16):1226-33.

20. Khaw KT, Dowsett M, Folkerd E, et al. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation 2007;116:2694-701.


For citation:


Kravchenko A.Y., Provotorov V.M. CLINICAL EFFECT OF TESTOSTERONE IN MEN WITH STABLE ANGINA. Rational Pharmacotherapy in Cardiology. 2009;5(1):37-41. (In Russ.) https://doi.org/10.20996/1819-6446-2009-5-1-37-41

Views: 327


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)