Preview

Rational Pharmacotherapy in Cardiology

Advanced search

THE LIS STUDY (LYUBERTSY STUDY OF MORTALITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION). EVALUATION OF THE PHARMACOTHERAPY. PART 1. TREATMENT OF PATIENTS BEFORE MYOCARDIAL INFARCTION AND ITS INFLUENCE ON HOSPITAL MORTALITY RATE

https://doi.org/10.20996/1819-6446-2012-8-5-681-684

Full Text:

Abstract

Aim. To assess the patients’ pharmacotherapy preceding the acute myocardial infarction (AMI) and to assess the effects of this therapy on hospital mortality. Material and methods. 1133 patients were enrolled into the LIS AMI register . All these patients experienced AMI leading to hospital admitting in the territory of one of the districts of the Moscow Region during 3 years. The pharmacotherapy that patients received before AMI was analyzed as well as the influence of different drugs on the hospital mortality risk. Results. 172 of 1133 patients (15.2%) died in hospital. Before admission 21.4% of patients received β-blockers, 35.3% — ACE inhibitors, 15.7% — antiplatelet drugs, 1.9% — statins. Reduction in the hospital mortality rate was shown for β-blockers [relative risk (RR)=0.542, confidence interval (CI) =0.357–0.824] and ACE inhibitors (RR=0.710, CI=0.512–0.986). Conclusion. A significant part of patients with high risk of AMI does not receive drugs with proven positive effect on the life prognosis.

About the Authors

S. Y. Marcevich
State Research Center for Preventive Medicine I.M. Setchenov First Moscow State Medical University
Russian Federation


M. L. Ginzburg
Lyubertsy regional hospital №2
Russian Federation


N. P. Kutishenko
State Research Center for Preventive Medicine I.M. Setchenov First Moscow State Medical University
Russian Federation


A. D. Deev
State Research Center for Preventive Medicine
Russian Federation


V. P. Smirnov
Lyubertsy regional hospital №2
Russian Federation


L. Y. Drozdova
State Research Center for Preventive Medicine
Russian Federation


E. V. Danijel's
Lyubertsy regional hospital №2
Russian Federation


A. V. Fokina
Lyubertsy regional hospital №2
Russian Federation


References

1. Bassand J.P., Hamm C.W., Ardissino D., et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J 2007;28(13):1598–1660.

2. Ruda M.Ja., Zysko A.P. Myocardial infarction. M.: Medicina; 1977. Russian (Руда М.Я., Зыско А.П. Инфаркт миокарда. М.: Медицина; 1977).

3. Van de Werf F., Bax J., Betriu A., et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008;29(23):2909–2945.

4. Perk J., De Backer G., Gohlke H., et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J 2012;33(13):1635– 1701.

5. Yusuf S., Islam S., Chow C.K., et al. Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey. Lancet 1 2011;378(9798):1231–1243.

6. Kotseva K., Wood D., De Backer G., et al. EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. Eur J Cardiovasc Prev Rehabil 2009;16(2):121–137.

7. Larsen J., Andersen M., Bjerrum L., et al. Insufficient use of lipid-lowering drugs and measurement of serum cholesterol among patients with a history of myocardial infarction. J Cardiovasc Risk 2003;10(1):61–64.

8. Martsevich S.Yu., Ginzburg M.L., Kutishenko N.P. et al. A lyubertsy study of mortality among patients with prior acute myocardial infarction: the first results of the LIS study. The Clinician 2011;1:24–27. Russian (Марцевич С.Ю., Гинзбург М.Л., Кутишенко Н.П. и соавт. Люберецкое исследование по изучению смертности больных, перенесших острый инфаркт миокарда. Первые результаты исследования «ЛИС». Клиницист 2011;1:24–27).

9. Marcevich S.Ju., Ginzburg M.L., Kutishenko N.P., et al. The LIS study (Lubertsy mortality study of patients with acute myocardial infarction): a portrait of the patient. Kardtovaskuljarnaja Terapija i Profilaktika 2011;10(6):89–93. Russian (Марцевич С.Ю., Гинзбург М.Л., Кутишенко Н.П., Деев А.Д., соавт. Исследование ЛИС (Люберецкое исследование смертности больных, перенесших острый инфаркт миокарда): портрет заболевшего. Кардтоваскулярная Терапия и Профилактика 2011;10(6):89–93).

10. National guidelines for diagnosis and treatment of patients with acute myocardial infarction with elevation ST. Kardiovaskuljarnaja terapija i profilaktika 2007;6 (8) suppl 1: 1–85. Russian (Национальные рекомендации по диагностике и лечению больных острым инфарктом миокарда с подъемом сегмента ST. Кардиоваскулярная терапия и профилактика 2007;6 (8) приложение 1: 1–85).

11. Martsevich S.Yu., Drozdova L.Yu., Voronina V.P. Health and education of a physician: two parts of the success. Rational Pharmacother Cardiol 2010;6(1):73–76. Russian (Марцевич С.Ю., Воронина В.П., Дроздова Л.Ю. Здоровье и образование врача: две составляющие успеха. РФК 2010;6(1):73–76).

12. Martsevich S.Yu., Drozdova L.Yu., Lukina Yu.V. et al. Evaluation by practicing doctors of the modern pharmacotherapy possibilities in patients with ischemic heart disease. Results of doctor interview in Moscow and Voronezh. Rational Pharmacother Cardiol 2010;6(2):145–148. Russian (Марцевич С.Ю., Дроздова Л.Ю., Лукина Ю.В., Синягина Н.В., Хелия Т.Г. Как оценивают практические врачи возможности современной медикаментозной терапии больных хронической ишемической болезнью сердца. Результаты опросов в Москве и Воронеже. РФК 2010;6(2):145–148).

13. Drozdova L.Yu., Martsevich S.Yu., Voronina V.P. Evaluation of cardiovascular risk factors prevalence and efficacy of their correction in physicians. Estimation of physicians’ expertise in up-to-date clinical guidelines. Results of the “Physician’s health and education” study. Rational Pharmacother Cardiol 2011;7(2):137–144. Russian (Дроздова Л.Ю., Марцевич С.Ю., Воронина В.П. Одновременная оценка распространенности и эффективности коррекции факторов риска сердечно-сосудистых заболеваний среди врачей и их знания современных клинических рекомендаций. Результаты проекта «Здоровье и образование врача». РФК 2011;7(2):137–144).


For citation:


Marcevich S.Y., Ginzburg M.L., Kutishenko N.P., Deev A.D., Smirnov V.P., Drozdova L.Y., Danijel's E.V., Fokina A.V. THE LIS STUDY (LYUBERTSY STUDY OF MORTALITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION). EVALUATION OF THE PHARMACOTHERAPY. PART 1. TREATMENT OF PATIENTS BEFORE MYOCARDIAL INFARCTION AND ITS INFLUENCE ON HOSPITAL MORTALITY RATE. Rational Pharmacotherapy in Cardiology. 2012;8(5):681-684. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-5-681-684

Views: 383


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)