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TITERS OF ANTIBODIES TO Β1-ADRENOCEPTOR AND M2 CHOLINERGIC RECEPTORS IN PATIENTS WITH VENTRICULAR ARRHYTHMIAS WITHOUT AN ORGANIC CARDIOVASCULAR DISEASE AND THEIR POSSIBLE CLINICAL SIGNIFICANCE

https://doi.org/10.20996/1819-6446-2012-8-5-647-654

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Abstract

Aim. To identify the most promising epitopes that simulate various sites β1-adrenergic and M2-cholinergic receptors, and to evaluate their possible contribution to the development and maintenance of cardiac arrhythmias, particularly idiopathic ventricular arrhythmia. Material and methods. Patients with ventricular arrhythmias without organic cardiovascular disease (the study group; n=70) were included in the study. The control group consisted of 20 healthy volunteers. Evaluation of levels of antibodies to antigenic determinants, modeling various sites β1-adrenergic and M2-cholinergic performed in all patients. Causal treatment with clarithromycin and valacyclovir performed in part of patients. Results. Antibodies to different peptide sequences of β1-adrenergic and M2-cholinergic receptors have been identified in 25% of main group patients. A direct correlation between the frequency of episodes of ventricular tachycardia and IgG levels to MRI-MRIV (p=0.02) revealed. Increase in titre of antibodies to β1-adrenoceptors, to a peptide sequence β8 (p=0.02), and lower titers of antibodies to the M2 acetylcholine receptor — chimera MRI-MRIV IgM (p=0.06) and ARI-MRIV IgM (p=0.07) were observed when assessing the efficacy of the therapy in the causal dynamics in the group of "untreated" patients. IgG titer reduction of ARI-MRIV (p=0.02), which is 4 times out of 10 with reduction of ventricular ectopic activity , recorded after valacyclovir therapy. Clarithromycin therapy on the level of antibodies exerted no significant effect. Conclusion. Possible involvement of antibodies to β1-adrenoceptor and M2-cholinergic receptors in the development of idiopathic ventricular arrhythmias demonstrated. The relationship between the frequency of episodes of ventricular tachycardia and levels of antibody titers to M2-cholinergic receptors found. Attempt of causal treatment, depending on the possible mechanisms of the autoimmune process is executed. Further studies to confirm or refute the results to the larger sample of patients are needed.

About the Authors

M. M. Rogova
Russian Cardiology Research and Production Complex
Russian Federation


N. A. Mironova
Russian Cardiology Research and Production Complex
Russian Federation


E. S. Rodionova
Russian Cardiology Research and Production Complex
Russian Federation


T. A. Malkina
Russian Cardiology Research and Production Complex
Russian Federation


K. A. Zykov
Russian Cardiology Research and Production Complex
Russian Federation


Zh. D. Bespalova
Russian Cardiology Research and Production Complex
Russian Federation


R. Sh. Bibilashvili
Russian Cardiology Research and Production Complex
Russian Federation


E. E. Efremov
Russian Cardiology Research and Production Complex
Russian Federation


S. P. Golitsyn
Russian Cardiology Research and Production Complex
Russian Federation


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For citation:


Rogova M.M., Mironova N.A., Rodionova E.S., Malkina T.A., Zykov K.A., Bespalova Z.D., Bibilashvili R.S., Efremov E.E., Golitsyn S.P. TITERS OF ANTIBODIES TO Β1-ADRENOCEPTOR AND M2 CHOLINERGIC RECEPTORS IN PATIENTS WITH VENTRICULAR ARRHYTHMIAS WITHOUT AN ORGANIC CARDIOVASCULAR DISEASE AND THEIR POSSIBLE CLINICAL SIGNIFICANCE. Rational Pharmacotherapy in Cardiology. 2012;8(5):647-654. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-5-647-654

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)