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The clinical case of a rare proarrhythmic effect of antiarrhythmic drugs with a poor prognosis (medication-induced atrial flutter in a patient with "malignant" Kent’s bundle) is presented. Radiofrequency ablation (RFA) is the most justified treatment method in patients with WPW-syndrome and "malignant" Kent’s bundle. RFA in descripted case has been postponed due to technical reasons. While waiting for RFA and after consideration of the potential risks and benefits the decision to use antiarrhythmic drugs to block the additional bundle was made. Paroxysm of broad-complex tachycardia developed on the third day of the treatment. It was regarded as a paroxysm of atrial fibrillation/flutter in the patient with WPW syndrome induced by taking antiarrhythmic drugs class 1C (allapinine). Review of the literature on the atrial fibrillation induced by antiarrhythmic of 1C class, and association of atrial fibrillation with WPW-syndrome is presented.

About the Authors

R. R. Mamatkazina
Institute of Clinical Cardiology named after A.L. Myasnikov , Russian Cardiology Research and Production Complex
Russian Federation

I. P. Kolos
State Research Center for Preventive Medicine
Russian Federation

S. E. Serdyuk
State Research Center for Preventive Medicine
Russian Federation

E. P. Mazygula
State Research Center for Preventive Medicine
Russian Federation

A. V. Sveshnikov
Russian National Medical and Surgical Center named after N.I. Pirogov
Russian Federation


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For citation:

Mamatkazina R.R., Kolos I.P., Serdyuk S.E., Mazygula E.P., Sveshnikov A.V. 1C-INDUCED ATRIAL FLUTTER IN A PATIENT WITH WPW SYNDROME: CASE REPORT AND REVIEW. Rational Pharmacotherapy in Cardiology. 2012;8(2):196-200. (In Russ.)

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