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CHARACTERISTICS OF PATIENTS WITH CEREBRAL STROKE OR TRANSIENT ISCHEMIC ATTACK, INCLUDED INTO THE LIS-2 REGISTER (LYUBERTSY STUDY OF MORTALITY IN PATIENTS AFTER STROKE)

https://doi.org/10.20996/1819-6446-2015-11-1-18-24

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Abstract

Aim. To provide final data on the three-year period of the inclusion of patients; to give most accurate "portrait" of patients hospitalized with a brain stroke within the framework of the LIS-2 register (Lyubertsy study of mortality in patients after stroke).

Material and methods. All patients (n=960) admitted to the Lyubertsy district hospital №2 with stroke for the period from 01.2009 to 12.2011 were included into the study.

Results. Men accounted for 37.5%, women - 62.5%, mean age was 71.1±9.8 years. The history of hypertension was present in 833 patients (86.8%), atrial fibrillation in 252 (26.8%) patients, 199 (20.7%) patients had previously undergone stroke. In-hospital mortality was 21.6% (207 patients had died; mean age 72.9±9.8 years). Low frequency of the antihypertensive therapy (34.5%), lipid-lowering therapy (0.7%), antiplatelet agents (5.7%), anticoagulation therapy prescription in patients with atrial fibrillation was detected.

Conclusion. Insufficient assignment of drugs with a proven effect on the prognosis in patients with risk factors prior to the development of the reference stroke draws attention. High incidence of recurrent strokes indicates an underactive secondary prevention.

About the Authors

S. Yu. Martsevich
State Research Centre for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


N. P. Kutishenko
State Research Centre for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


A. Yu. Suvorov
State Research Centre for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


M. L. Ginzburg
State Research Centre for Preventive Medicine, Lyubertsy Regional Hospital №2
Russian Federation

Petroverigsky per. 10, Moscow, 101990 Russia

Oktyabr’skiy prospect 338, Moscow Region, Lyubertsy, 140006 Russia



A. D. Deev
State Research Centre for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


S. A. Boytsov
State Research Centre for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


A. V. Akimova

Russian Federation
the "LIS-2" study Working Group


E. V. Daniels

Russian Federation
the "LIS-2" study Working Group


N. A. Dmitrieva

Russian Federation
the "LIS-2" study Working Group


L. Yu. Drozdova

Russian Federation
the "LIS-2" study Working Group


N. Yu. Zhuravskaya

Russian Federation
the "LIS-2" study Working Group


O. V. Lerman

Russian Federation
the "LIS-2" study Working Group


Yu. V. Lukina

Russian Federation
the "LIS-2" study Working Group


M. M. Loukianov

Russian Federation
the "LIS-2" study Working Group


V. P. Smirnov

Russian Federation
the "LIS-2" study Working Group


A. V. Fokina

Russian Federation
the "LIS-2" study Working Group


References

1. Demographic Yearbook of Russia. Moscow: Rosstat; 2012. Russian (Демографический ежегодник России. Москва: Росстат; 2012).

2. Thrift AG, Cadilhac DA, Thayabaranathan T, et al. Global stroke statistics. International journal of stroke: official journal of the International Stroke Society. 2014;9(1):6-18.

3. Boytso SA, Martsevich SYu, Kutishenko NP, et al. The registers in cardiology. Basic rules of conduct and a real opportunity. Kardiovaskulyarnaya Terapiya i Profilaktika 2013; 12 (1): 4-9.Бойцов С. А. Марцевич С.Ю., Кутишенко Н. П., и др. Регистры в кардиологии. Основные правила проведения и реальные возможности. Кардиоваскулярная Терапия и Профилактика 2013;12(1):4-9.

4. Strom B. L. Kimmel S. E., Hennessy S. Pharmacoepidemiology. 5 ed. Chichester, West Sussex, UK: Wiley-Blackwell; 2012.

5. Gliklich R. E., Dreyer N. A. Registries for Evaluating Patient Outcomes: A User's Guide: Rockville (MD): Agency for Healthcare Research and Quality (US); 2010.

6. Spirin NN, Korneeva NN. These hospital stroke in Kostroma. Fundamental'nye Issledovaniya 2012; 4: 123-8. Russian (Спирин Н.Н., Корнеева Н.Н. Данные госпитального инсульта в Костроме. Фундаментальные Исследования 2012;4:123-8).

7. Malakshinova ZH, Manzhueva TK, Tsyrenov BTs. Morbidity and mortality from stroke in Ulan-Ude, according to the register in 2005-2007. Byulleten' VSNTs SO RAMN 2008; 3 (61): 99-100. Russian (Малакшинова З.Х., Манжуева Т.К., Цыренов Б.Ц. Заболеваемость и смертность от мозгового инсульта в г. Улан-Удэ по данным регистра за 2005-2007 гг. Бюллетень ВСНЦ СО РАМН 2008;3(61):99-100).

8. Lebedev IA, Anischenko LI, Akinina SA, et al. Clinical and epidemiological features of stroke in the Khanty-Mansiysk Autonomous Okrug (according to the population register). Vestnik Rossiyskoy Voennomeditsinskoy Akademii 2011; 3 (35): 103-7. Russian (Лебедев И.А., Анищенко Л.И., Акинина С.А., и др. Клинико-эпидемиологические особенности мозгового инсульта в Ханты-Мансийском автономном округе (по данным популяционного регистра). Вестник Российской Военно-медицинской Академии 2011;3(35):103-7).

9. Kotova EY, Mashin VV. Epidemiology and major risk factors for stroke in Ulyanovsk (according to the register of stroke). Ul'yanovskiy Mediko-biologicheskiy Zhurnal 2011; 2: 100-7. Russian (Котова Е.Ю., Машин, В.В. Эпидемиология и основные факторы риска развития инсульта в г. Ульяновске (по данным регистра инсульта). Ульяновский Медико-биологический Журнал 2011;2:100-7).

10. Starodubtseva OS, Begicheva SV. Analysis of the incidence of stroke with the use of information technology. Fundamental'nye Issledovaniya 2012; 8: 424-7. Russian (Стародубцева О.С., Бегичева С.В. Анализ заболеваемости инсультом с использованием информационных технологий. Фундаментальные Исследования 2012;8:424-7).

11. Bidenko MA, Shprakh BB, Martynenko EA. Structure, outcomes and risk factors of stroke according to the hospital register in Irkutsk. Sibirskiy Meditsinskiy Zhurnal 2008; 4: 5-8. Russian (Биденко М.А., Шпрах ВВ., Мартыненко Е.А. Структура, исходы и факторы риска мозговых инсультов по данным госпитального регистра в г. Иркутске. Сибирский Медицинский Журнал 2008;4: 5-8).

12. Suvorov A., Martsevich SY, Kutishenko NP. Assessment of quality of care in the registers of acute stroke. Foreign experience and prospects of Russia. Kardiovaskulyarnaya Terapiya i Profilaktika 2014; 13 (4): 81-6. Russian (Суворов А.Ю., Марцевич С.Ю., Кутишенко Н.П. Оценка качества терапии в регистрах острого нарушения мозгового кровообращения. Зарубежный опыт, перспективы России. Кардиоваскулярная Терапия и Профилактика 2014;13(4):81-6).

13. European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008;25(5):457-507.

14. Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke 2011;42(1):227-76.

15. Martsevich SY, Kutishenko NP, Tolpygina SN, et al. Efficacy and safety of drug therapy for primary and secondary prevention of cardiovascular disease. Ration Pharmacother Cardiol 2011; 7 (5) suppl: 2-72. Russian (Марцевич С.Ю., Кутишенко Н.П., Толпыгина С.Н., и др. Эффективность и безопасность лекарственной терапии при первичной и вторичной профилактике сердечно-сосудистых заболеваний. Рациональная Фармакотерапия в Кардиологии 2011;7(5) Приложение: 2-72.

16. Ищнеыщм SA, Martsevich SY,г Ginzburg, ML, et al. Lubertsy study mortality in patients after stroke or transient ischemic attack (PIM-2). Design and evaluation of drug therapy. Ration Pharmacother Cardiol 2013; 9 (2): 114-22. Russian (Бойцов С.А., Марцевич С.Ю., Гинзбург М.Л., и др. Люберецкое исследование смертности больных, перенесших мозговой инсульт или транзиторную ишемическую атаку (ЛИС-2). Дизайн и оценка лекарственной терапии. Рациональная Фармакотерапия в Кардиологии 2013;9(2):114-22).

17. O'Donnell MJ, Xavier D, Liu L, et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010;376(9735):112-23.

18. Martsevich SYu, Ginzburg ML, Kutishenko NP, et al. The study of LIS (Lubertsy study of mortality in patients with acute myocardial infarction): a portrait of the sick. Kardiovaskulyarnaya Terapiya i Profilaktika 2011; 10 (6): 89-93. Russian (Марцевич С.Ю., Гинзбург М.Л., Кутишенко Н.П., и др. Исследование ЛИС (Люберецкое исследование смертности больных, перенесших острый инфаркт миокарда): портрет заболевшего. Кардиоваскулярная Терапия и Профилактика 2011;10(6):89-93).

19. Bel'skaya GN, Samoilova OB. Epidemiological aspects of stroke in Chelyabinsk. Vestnik YuUrGU 2008; 19: 71-4. Russian (Бельская Г.Н., Самойлова О.Б. Эпидемиологические аспекты острых нарушений мозгового кровообращения в г. Челябинске. Вестник ЮУрГУ 2008;19:71-4).

20. Fonarow GC, Reeves MJ, Smith EE, et al. Characteristics, performance measures, and in-hospital outcomes of the first one million stroke and transient ischemic attack admissions in get with the guidelinesstroke. Circulation Cardiovascular quality and outcomes 2010;3(3):291-302.

21. George MG, Tong X, McGruder H, et al. Paul Coverdell National Acute Stroke Registry Surveillance - four states, 2005-2007. MMWR Surveill Summ 2009;58(7):1-23.

22. Niewada M, Skowronska M, Ryglewicz D, et al. Acute ischemic stroke care and outcome in centers participating in the Polish National Stroke Prevention and Treatment Registry. Stroke 2006;37(7):1837-43.

23. Grau AJ, Eicke M, Biegler MK, et al. Quality monitoring of acute stroke care in Rhineland-Palatinate, Germany, 2001-2006. Stroke 2010;41(7):1495-500.

24. Aarnio K, Haapaniemi E, Melkas S, et al. Long-term mortality after first-ever and recurrent stroke in young adults. Stroke 2014;45(9):2670-6.

25. Steiner T, Juvela S, Unterberg A, et al. European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis 2013;35(2):93-112.

26. Steiner T, Al-Shahi Salman R, Beer R, et al. European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage. International journal of stroke 2014;9(7):840-55.

27. Meschia JF, Bushnell C, Boden-Albala B, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014;45(12):3754-832.

28. Kernan WN, Ovbiagele B, Black HR, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/ American Stroke Association. Stroke 2014;45(7):2160-236.

29. Connolly ES Jr., Rabinstein AA, Carhuapoma JR, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/ american Stroke Association. Stroke 2012;43(6):1711-37.

30. Suvorov AYu., Martsevich SYu. Modern principles of assessing the quality of the treatment of cardiovascular diseases. Ration Pharmacother Cardiol 2014; 10 (4): 397-401. Russian (Суворов А.Ю., Марцевич С.Ю. Современные принципы оценки качества проводимого лечения сердечно-сосудистых заболеваний. Рациональная Фармакотерапия в Кардиологии 2014;10(4):397-401).


Review

For citations:


Martsevich S.Yu., Kutishenko N.P., Suvorov A.Yu., Ginzburg M.L., Deev A.D., Boytsov S.A., Akimova A.V., Daniels E.V., Dmitrieva N.A., Drozdova L.Yu., Zhuravskaya N.Yu., Lerman O.V., Lukina Yu.V., Loukianov M.M., Smirnov V.P., Fokina A.V. CHARACTERISTICS OF PATIENTS WITH CEREBRAL STROKE OR TRANSIENT ISCHEMIC ATTACK, INCLUDED INTO THE LIS-2 REGISTER (LYUBERTSY STUDY OF MORTALITY IN PATIENTS AFTER STROKE). Rational Pharmacotherapy in Cardiology. 2015;11(1):18-24. (In Russ.) https://doi.org/10.20996/1819-6446-2015-11-1-18-24

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