Rational Pharmacotherapy in Cardiology

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Aim. To study the possibility of enhancing the antianginal effect of long-acting nitrates by their combination with trimetazidine in patients with stable angina. Material and methods. Patients with ischemic heart disease (IHD, stable angina; n=55) were included into the study. Patients were randomized to receive trimetazidine 35 mg 2 times a day (intervention group) or placebo (control group) in addition to standard therapy. A daily number of angina attacks, amount of short-acting nitroglycerin tablets consumed per week, exercise tolerance by the bicycle ergometry with the calculation of the threshold power and the work capacity were assessed at baseline and after 2 months of the drugs taking, as well as 2 months after the drugs withdrawal. Results. Significant reduction in nitroglycerin tablets consumption (1 month — by 61.8%, after 2 months — 72.5%, p<0.05) were found in the intervention group compared with the control group. Low intake of nitroglycerin compared with baseline (p<0.05) was maintained for 2 months after discontinuation of study drug. Significant increase in the threshold power (1 month — by 32.3%, after 2 months — 37.5%, p<0.05) was observed in the intervention group compared to baseline and with the control group. Conclusion. Trimetazidine in the treatment of stable angina has high clinical efficacy.

About the Authors

L. E. Chekuldaeva
Medical Care Unit №2, Samara
Russian Federation

S. V. Obuhova
Medical Care Unit №2, Samara
Russian Federation

A. A. Simakov
Samara Medical Institute "Reaviz"
Russian Federation

L. V. Poljaeva
Medical Care Unit №2, Samara
Russian Federation

E. I. Rjazanova
Medical Care Unit №2, Samara
Russian Federation


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For citations:

Chekuldaeva L.E., Obuhova S.V., Simakov A.A., Poljaeva L.V., Rjazanova E.I. THE PROBLEM OF INTERCHANGEABILITY OF DRUG PRODUCTS. TRIMETAZIDINE IS AN EFFECTIVE TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE. Rational Pharmacotherapy in Cardiology. 2012;8(4):515-520. (In Russ.)

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