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COMPARATIVE EFFECTIVENESS PIPOFEZINE, TIANEPTINE AND CHLORPROTHIXENE IN PATIENTS WITH ATTENTION DEFICIT DISORDER , AND HYPERTENSION: AN OPEN NON-RANDOMIZED STUDY

https://doi.org/10.20996/1819-6446-2012-8-3-447-452

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Abstract

Aim. To evaluate the influence of pipofezine, tianeptine and chlorprothixene on blood pressure (BP) level and neuropsychological performance in patients with attention deficit hyperactivity disorder (ADHD) and arterial hypertension (HT). Material and methods. Young males with ADHD and HT (n=58) were included into the study. Patients were split into three treatment groups: group 1 (n=19) received pipofezine 50 mg/day, group 2 (n=20) — tianeptine 25 mg/day , group 3 (n=19) — chlorprothixene 50 mg/day. Clinicopsychopathologic and neurophysiological findings were evaluated at baseline and after 4 weeks of treatment. BP self-monitoring, analysis of psychiatric disorders severity with Brief Psychiatric Rating Scale, electroencephalography (EEG) were performed. Results. The positive dynamics of disregulatory-motor hyperactivity , subjective-cognitive and emotional-vegetative components of ADHD was observed. The positive dynamics of neurophysiological parameters (increase in EEG frequencies index) in groups 1 and 2 (from 0.37±0.05 to 0.54±0.07 and 0.38±0.06 to 0.50±0.05, respectively , p<0.05 for both) was also found. There were no significant effects of the study drugs on BP levels in patients of all groups (p>0.05). Conclusion. Four-week usage of the study drugs in adolescents with ADHD and HT had no significant effect on BP levels. Pipofezine and tianeptine showed more pronounced improvement of clinicopsychiatric and neuropsychological performance in comparison with chlorprothixene in patients with ADHD.

About the Author

V. V. Glushchenko
Institute of Medical Education, Yaroslav-the-Wise Novgorod State University Novgorod Regional psychoneurologic dispensary
Russian Federation


References

1. Dorozhenok I.Yu. XX European Congress of Neuropsychopharmacology. Psikhicheskie Rasstroystva v Obshchey Meditsine 2007; (4): 75–77. Russian (Дороженок И.Ю. XX Европейский конгресс по ней-ропсихофармакологии. Психические Расстройства в Общей Медицине 2007; (4): 75–77).

2. Gillis JJ, Gilger JW, Pennington BF, DeFries JC. Attention deficit disorder in reading-disabled twins: evidence for a genetic etiology. J Abnorm Child Psychol 1992; 20(3): 303–15.

3. Cormier E. Attention deficit/hyperactivity disorder: a review and update. J Pediatr Nurs 2008; 23 (5): 345–357.

4. Barkley R. A. Attention deficit hyperactive disorder: A handbook for diagnosis and treatment. New York: Guilford Press; 1990.

5. Mosolov S.N. Clinical use of modern antidepressants. St. Petersburg: Meditsinskoe informatsionnoe agentstvo; 1995. Russian (Мосолов С.Н. Клиническое применение современных антидепрессантов. СПб.: Медицинское информационное агентство; 1995).

6. Mutaf'yan O.A. Hypertension and hypotension in children and adolescents. How. St. Petersburg: Nevskiy dialekt; 2002. Russian (Мутафьян О.А. Артериальная гипертензия и гипотензии у детей и подростков. Практическое руководство. СПб.: Невский диалект; 2002).

7. Shapiro P.A. Heart Disease. In Levenson JL, ed. Textbook of Psychosomatic Medicine. Washington, DC: American Psychiatric Publishing, Inc.; 2005: 423–444.

8. Smulevich A.B., Syrkin A.L. Psychocardiology. Psikhicheskie Rasstroystva v Obshchey Meditsine 2007; (4): 4–9. Russian (Смулевич А.Б., Сыркин А.Л. Психокардиология. Психические Расстройства в Общей Медицине 2007; (4): 4–9).

9. Krasnov V.N., Gurovich I.Ya., editors. Clinical Manual: Models of diagnosis and treatment of mental and behavioral disorders. Moscow: Moskovskiy NII psikhiatrii Minzdrava Rossii; 1999. Russian (Краснов В.Н., Гурович И.Я., редакторы. Клиническое руководство: Модели диагностики и лечения психических и поведенческих расстройств. М.: Московский НИИ психиатрии Минздрава России; 1999).

10. Overall JE, Pfefferbaum B. The Brief Psychiatric Rating Scale for Children. Psychopharmacol Bull 1982;18(2):10–6.

11. Ivanov L.B. Applied computer electroencephalography. Moscow: AOZT «Antidor»; 2000. Russian (Иванов Л.Б. Прикладная компьютерная электроэнцефалография. М.: АОЗТ «Антидор»; 2000).

12. Alekseeva L.A., Gusev O.A., Kochorova L.V. et al. Basic methods of statistical analysis (guidelines for students, medical residents and graduate students). St. Petersburg: Izdatel'stvo Gosudarstvennogo meditsinskogo universiteta im. akad. I.P.Pavlova; 1997. Russian (Алексеева Л.А., Гусев O.A., Кочорова Л.В. и др. Основные методы статистического исследования (методические указания для студентов, клинических ординаторов и аспирантов). СПб.: Издательство Государственного медицинского университета им. акад. И.П.Павлова; 1997).

13. Gnezditskiy V.V. The inverse problem of EEG and Clinical Electroencephalography. Taganrog: TRTU; 2000. Russian (Гнездицкий В.В. Обратная задача ЭЭГ и клиническая электроэнцефалография. Таганрог: ТРТУ; 2000).

14. Holstege G, Bandler R, Saper CB. The emotional motor system. Prog Brain Res 1996;107:3–6. Поступила: 05.08.2011


For citation:


Glushchenko V.V. COMPARATIVE EFFECTIVENESS PIPOFEZINE, TIANEPTINE AND CHLORPROTHIXENE IN PATIENTS WITH ATTENTION DEFICIT DISORDER , AND HYPERTENSION: AN OPEN NON-RANDOMIZED STUDY. Rational Pharmacotherapy in Cardiology. 2012;8(3):447-452. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-3-447-452

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ISSN 1819-6446 (Print)
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