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Rational Pharmacotherapy in Cardiology

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EFFECTS OF METABOLIC DRUG ELTACINE ON CLINICAL, FUNCTIONAL AND BIOCHEMICAL INDICES IN PATIENTS WITH CHRONIC HEART FAILURE

https://doi.org/10.20996/1819-6446-2007-3-1-33-36

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Abstract

Aim. To study clinical efficacy of a new domestic metabolic drug Eltacine in patients with chronic heart failure (CHF).

Material and methods. 134 patients with CHF of I-III functional classes were randomized in two parallel groups of patients receiving Eltacine or placebo additionally to standard therapy. Common clinical and laboratory investigations were used as well as 6-minute-walking test and Echocardio￾graphy. Besides Holter monitoring with determination of heart rate variability, peroxidal oxidation of lipids (POL) and cell anti-oxidant protection were implemented.

Results. Eltacine increased in tolerance to physical burden, improved cardiac haemodynamics, parameters of POL and cell anti-oxidant protection, improved the patient quality of life.

Conclusion. The efficacy and safety of Eltacine as metabolic and antioxidant therapy was shown in patients with CHF.

About the Authors

R. M. Zaslavskaya
City clinical Hospital N 60, Institute of cytochemistry and molecular pharmacology, Moscow
Russian Federation


G. V. Lilitsa
City clinical Hospital N 60, Institute of cytochemistry and molecular pharmacology, Moscow
Russian Federation


Ye. V. Kalinina
City clinical Hospital N 60, Institute of cytochemistry and molecular pharmacology, Moscow
Russian Federation


I. A. Komissarova
City clinical Hospital N 60, Institute of cytochemistry and molecular pharmacology, Moscow
Russian Federation


L. N. Maximova
City clinical Hospital N 60, Institute of cytochemistry and molecular pharmacology, Moscow
Russian Federation


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For citation:


Zaslavskaya R.M., Lilitsa G.V., Kalinina Y.V., Komissarova I.A., Maximova L.N. EFFECTS OF METABOLIC DRUG ELTACINE ON CLINICAL, FUNCTIONAL AND BIOCHEMICAL INDICES IN PATIENTS WITH CHRONIC HEART FAILURE. Rational Pharmacotherapy in Cardiology. 2007;3(1):33-36. (In Russ.) https://doi.org/10.20996/1819-6446-2007-3-1-33-36

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)