Preview

Rational Pharmacotherapy in Cardiology

Advanced search

ASSESSMENT OF INFLUENCE OF BETAGISTIN IN COMBINATION WITH ANTIHYPERTENSIVE DRUGS ON QUALITY OF LIFE AND NEUROLOGICAL STATUS OF PATIENTS WITH STABLE ARTERIAL HYPERTENSION AND DIZZINESS

https://doi.org/10.20996/1819-6446-2005-1-2-25-31

Full Text:

Abstract

More than a half of patients with stable mild to moderate arterial hypertension (AH) have dizziness. Rather often these patients need to take drugs, reducing blood pressure (BP) in combination with those, reducing intensity of dizziness. As patients with stable AH have bad compliance with the treatment, it is necessary to consider not only drug efficiency, but also its influence on quality of life (QL).

Aim. To assess influence of combined therapy with betagistin hydrochlorid and lisinopril on QL and neurological status of patients with stable mild to moderate AH.

Material and methods. 67 patients with stable AH of I-II grades, risk 2-3 and medium intensity of dizziness took part in randomized, cross over design, placebo-controlled study. After 2 weeks of “wash-out” period all patients received lisinopril alone or lisinopril in combination with betagistin. Every therapy regimes lasted 1 mouth. Evaluation of QL, intensity of dizziness, daily BP was made before and at the end of each therapy regimes, evaluation of neurological status – before and at the end of the first therapy regime.

Results. Therapy with both schemes of treatment resulted in comparable decrease in BP level. Treatment with both regimes relieved dizziness and concomitant symptoms. Combined therapy with betagistin and lisinopril showed improvement of almost all the elements of QL, while monotherapy with lisinopril – of only several ones. Combined treatment with lisinopril and betagistin had more favorable influence on QL, and neurological status.

Conclusion. The main reason, which caused dizziness in patients with stable AH, was chronic double-sided changes in vestibular system. Com￾bined treatment with lisinopril and betagistin had more positive influence on QL and neurological status than monotherapy with lisinopril. BP decrease according to the two schemes of therapy was comparative in both therapy regimes.

About the Authors

G. V. Andreeva
State Research Center for Preventive Medicine of Roszdrav, Мoscow
Russian Federation


S. Y. Martsevich
State Research Center for Preventive Medicine of Roszdrav, Мoscow
Russian Federation


V. M. Gorbunov
State Research Center for Preventive Medicine of Roszdrav, Мoscow
Russian Federation


O. A. Melnikov
АNО «Guta Clinic», Moscow
Russian Federation


V. P. Voronina
State Research Center for Preventive Medicine of Roszdrav, Мoscow
Russian Federation


I. P. Zhigareva
State Research Center for Preventive Medicine of Roszdrav, Мoscow
Russian Federation


References

1. Oostervelg W.J. Current diagnostic techniques in vestibular disorders. Acta Otolaryngol 1991; 479 (Suppl): 29-34.

2. Андреева Г.Ф., Горбунов В.М., Жигарева И.П. и др. Распространенность и наиболее частые причины возникновения головокружения у больных со стабильной артериальной гипертензией. Кардиоваск тер профил 2004;2:17-24.

3. Шальнова С.А., Деев А.Д., Вихирева О.В. и др. Артериальная гипертония. Информированность, лечение, контроль. Укрепление здоровья и профилактика заболеваний. M. 2001;4:3-7.

4. Лазебник Л.Б., Гайнулин Ш.М., Дроздов В.Н. Организационные мероприятия по борьбе с артериальной гипертонией в г. Москве. Российский кардио. журн. 2003; 5: 5-10.

5. Андреева Г.Ф., Горбунов В.М., Марцевич С.Ю. Оценка уровня информированности о своем заболевании больных со стабильной артериальной гипертензией. Рациональная фармакотерапия в кардиологии 2005;1: 9-12.

6. Леви Л., Андерсон А. Народонаселение, окружающая среда и качество жизни. М; Медицина; 1979.

7. Crooq S.H., Levine S., Testa M.A. et al. The effect of antihypertensive therapy on the quality of life. The New Engl J Med 1986; 314(26): 1657-1664.

8. Siegrist J., Jungle A. Conceptual and methodological problem in research on the quality of life in clinical medicine. Soc Sci Med 1989; 29(3):463-8.

9. Андреева Г.Ф., Горбунов В.М., Исайкина О.Ю., Лерман О.В., Воронина В.П. Сравнительная оценка воздействия малых доз эналаприла и телмисартана на качество жизни и гемодинамические показатели больных со стабильной артериальной гипертензией. Российский кардио. журн. 2002;4:36-39.

10. Dahlof B., Lindholm L.H., Carney S. et al. Main results of the losartan versus amlodipin study on drug tolerabilitty and psychological general well-being. J Hypertens 1997; 15(11):1372-1335.

11. James A.L., Burton M.J. Betahistine for Meniere’s disease or syndrome (Cochrane Rewiev). The Cochrane Libraty. Oxford.2001.

12. Burns R.A. Basilar vertebral artery insufficiency as a cause of vertigo; in the Otoloryng. Clinics of North America, Symposium on vertigo. Philadelphia. London. Toronto,1973.

13. Головокружение. Под ред. М.Р. Дикса, Дж.Д. Худа. М.,1989.

14. Афанасьева С.А., Горбачева Ф.Е., Натяжкина Г.М. Изолированное системное головокружение: патогенез и эффективность бетагистина (бетасерка). Неврологич. журн.2003. N4;38-41.


For citation:


Andreeva G.V., Martsevich S.Y., Gorbunov V.M., Melnikov O.A., Voronina V.P., Zhigareva I.P. ASSESSMENT OF INFLUENCE OF BETAGISTIN IN COMBINATION WITH ANTIHYPERTENSIVE DRUGS ON QUALITY OF LIFE AND NEUROLOGICAL STATUS OF PATIENTS WITH STABLE ARTERIAL HYPERTENSION AND DIZZINESS. Rational Pharmacotherapy in Cardiology. 2005;1(2):25-31. (In Russ.) https://doi.org/10.20996/1819-6446-2005-1-2-25-31

Views: 417


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)