EFFECT OF CHOLESTEROL BLOOD LEVEL REDUCTION BEGINNING EARLY IN LIFE ON THE RISK OF ISCHEMIC HEART DISEASE
Abstract
Comments to the paper B.A. Ference, et al. Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease. A Mendelian Randomization Analysis (translation is published in №1 2013:90-98)
About the Author
N. V. PerovaRussian Federation
References
1. Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 2003;290:2277–3.
2. Cohen J, Pertsemlidis A, Kotowski IK, et al. Low LDLcholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005;37: 161–.
3. Kathiresan S. A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. N Engl J Med 2008;358:2299–300.
4. Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol 2012; 60:2631–.
5. Cholesterol Treatment Trialists’ (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010;376:1670–1.
6. Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008;118:672–.
7. Avis HJ, Hutten BA, Gagne C, et al. Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia. Jam Coll Cardiol 2010;55:1121–.
Review
For citations:
Perova N.V. EFFECT OF CHOLESTEROL BLOOD LEVEL REDUCTION BEGINNING EARLY IN LIFE ON THE RISK OF ISCHEMIC HEART DISEASE. Rational Pharmacotherapy in Cardiology. 2013;9(2):203-204. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-2-203-204