Rational Pharmacotherapy in Cardiology

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Chronic heart failure (CHF) is a major health problem in many countries now, and the cost of hospitalization is high. Early detection of atrial dysfunction, relationships between onset of symptoms and dysfunction of the atria, as well as their role in the development of systolic and diastolic heart failure is important. Interest in the assessment of left atrial transthoracic echocardiography with calculation of left atrial function index (LAFI) fraction and assessment of myocardial fibrosis with special software packages takes place lately. The search for ways to develop non-invasive methods for determining the fraction of atrial fibrosis and dysfunction is now underway. Detection of the most sensitive and specific methods will help to diagnose the initial manifestation of CHF and find an individualized approach to the treatment of each patient.

About the Authors

O. M. Drapkina
I.M. Sechenov First Moscow State Medical University
Russian Federation

E. V. Cherkunova
I.M. Sechenov First Moscow State Medical University
Russian Federation


1. CrisanD., CarrJ. Angiotensin I-converting enzyme genotype and disease associations.JMD 2000; 2(3): 105-15.

2. Hoeper M.M., Tacacs A., Stellmacher U. et al. Lack of association between angiotensin converting enzyme [ACE] genotype, serum ACE activity, and haemodynamics in patients with primary pulmonary hypertension. Heart 2003;89:445-6.

3. Danser A.H.J., Schalekamp M.A.D.H., Bax W.A. et al. Angio-tensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 1995; 92: 1387-8.

4. Carey R. M., SiragyH. M. Newly recognized components of the renin-angiotensin system: potentialroles in cardiovascular and renal regulation. End Reviews 2003; 24(3): 261-71.

5. Muller D.N., Bohlender J., Hilgers K.F. et al. Vascular angiotensin-converting enzyme expression regulates local angiotensin II. Hypertension 1997; 29: 98-104.

6. Drapkina OM. Fibrosis and activation of the renin-angiotensin-aldosterone system. Arterial Hypertension 2012;18 (5): 1-10. Russian (Драпкина О.М. Фиброз и активация ренин-ангиотензиновойальдостероной системы. Артериальная Гипертензия 2012; 18(5): 1-10).

7. Ehrlich J.R., Hohnloser S.H., Nattel S. Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence. Eur Heart J 2005; 27(5):512-8.

8. Fumitaka Kuwahara, Hisashi Kai, Keisuke Tokuda. Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 2002; 106(1):130-8.

9. Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest 2007;117(3):568-75.

10. Dubolazova YV, Drapkina OM. The use of biological markers in the diagnosis of diastolic heart failure. Heart failure 2011; 12 (6): 364-73. Russian (Дуболазова Ю.В., Драпкина О.М. Применение биологических маркеров в диагностике диастолической сердечной недостаточности. Сердечная Недостаточность 2011; 12(6): 364-73).

11. Hornig B., Kochler C., Drexler H. Role of bradikinine in mediating vascular effects of angiotensin-converting enzyme inhibitors in humans. Circulation 1997; 95: 1115-8.

12. GudkovAY, Semernin EN, Baranov EI and other structural and functional characteristics ofthe myocardium of patients with idiopathic restrictive cardio myopathy. Bulletin of arrhythmology 2003; 33: 37-8. Russian (Гудкова А.Я., Семернин Е.Н., Баранова Е.И. и др. Структурно-функциональная характеристика миокарда больных идиопатической рестриктивной кардио-миопатией. ВестникАритмологии 2003; 33: 37-8).

13. Morgan JP. Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction. N Engl J Med 1991; 325:625-32.

14. Nishimura R.A., Abel M.D., Hatle L.K., Tajik A.J. Assessment of diastolic function of the heart; background and current applications of Doppler echocardiography. Part II. Clinical studies. Mayo Clin Proc 1989;64:181-204.

15. Welles CC, Ku IA, Kwan DM et al. Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol 2012;59(7):673-80.

16. Drapkina OM, Ashihmin YaI, Ivashkin VT. Complexity of clinical diagnosis and treatment of diastolic congestive heart failure. Heart Failure 2009; 10(4): 3-10. Russian (Драпкина О.М., Ашихмин Я.И., Ивашкин В.Т. Сложности клинической диагностики и лечения диастолической хронической сердечной недостаточности. Сердечная Недостаточность 2009; 10(4): 3-10).

17. Burniston J.G., Saini A., Tan L., Goldspink D.F. Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat. Exp Physiology 2005; 90: 755-61.

For citation:

Drapkina O.M., Cherkunova E.V. EVALUATION OF ATRIAL CONTRACTILE FUNCTION DISORDERS AND FIBROSIS AS PREDICTORS OF CHRONIC HEART FAILURE. Rational Pharmacotherapy in Cardiology. 2014;10(2):231-237. (In Russ.)

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