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THE PREVALENCE OF ELEVATED LEVELS OF C-REACTIVE PROTEIN AND ITS ASSOCIATION WITH TRADITIONAL RISK FACTORS AND MORBIDITY AMONG RESIDENTS OF THE RUSSIAN FEDERATION (ACCORDING TO THE ESSE-RF STUDY)

https://doi.org/10.20996/1819-6446-2014-10-6-19-23

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Abstract

Aim. To study the association of high-sensitivity C-reactive protein (hsCRP) level with socio-demographic, behavioral and traditional risk factors in different regions of the Russian Federation (RF).

Material and methods. Data of the multicenter epidemiological study of cardiovascular disease in different regions of the Russian Federation (ESSE-RF) were used. Representative sample of the unorganized male and female population aged 25-64 from 6 regions of the Russian Federation was drown. 3407 men and 6354 women (n=9761) were included into the study. Standard questionnaire was applied in all subjects. Gender, age, level of education, place of residence and region of residence, traditional risk factors and diseases were analyzed. HsCRP level (level ≥3.0 mg/l was defined as elevated one) was evaluated to detect of indolent inflammation.

Results. HsCRP levels in women was significantly higher compared to males (p<0.005). The average prevalence of elevated hsCRP in the regions was 24.2%, for men - 21.4%, and for women - 25.7% (p<0.005). Significant age-related dynamics of hsCRP (p<0.0001) was found. The average level of hsCRP was significantly lower (p<0.0001) in a cohort of persons with higher education against these with lower level of education. Level of hsCRP as well as prevalence of elevated hsCRP level were higher in villagers than this in the urban population (p<0.05). Prevalence of elevated hsCRP in patients with traditional risk factors after adjustment for sex, age, and region of residence showed that the elevated hsCRP was mostly associated with metabolic factors and diseases that were characterized by systemic inflammation.

Conclusion. Elevated level of hsCRP (≥3.0 mg/l) was significantly associated with female gender, with an older, less educated, and smoking population of Russians. After the multivariate adjustment there remained significant associations (p<0.0001) of elevated hsCRP level with obesity, including abdominal obesity, hyperglycemia and hypertriglyceridemia, low levels of low density cholesterol, rheumatoid arthritis, chronic bronchitis and Parkinson's disease.

About the Authors

S. E. Evstifeeva
State Research Center for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


S. A. Shalnova
State Research Center for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


A. D. Deev
State Research Center for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


T. M. Gatagonova
North Ossetia State Medical Academy
Russian Federation
Pushkinskaya ul. 40, Vladikavkaz, North Ossetia-Alania Republic, 362019 Russia


A. Yu. Efanov
Tyumen State Medical Academy
Russian Federation
Odesskaya ul. 54, Tyumen, 625023 Russia


Yu. V. Zhernakova
Russian Cardiology Research and Production Complex
Russian Federation
3rd Cherepkovskaya ul. 15a, Moscow, 121552 Russia


V. A. Il'in
Institute of Socio-Economic Development of Territories, Russia Academy of Ssiences
Russian Federation
Gorkogo ul. 56a, Vologda, 160014 Russia


A. O. Konradi
Federal Almazov Medical Research Centre
Russian Federation
Akkuratova ul. 2, St. Petersburg, 197341 Russia


V. A. Metelskaya
State Research Center for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


E. V. Oschchepkova
Russian Cardiology Research and Production Complex
Russian Federation
3rd Cherepkovskaya ul. 15a, Moscow, 121552 Russia


S. V. Romanchuk
Ivanovo Municipal Cardiology Hospital
Russian Federation
Sheremetyevsky prosp. 22, Ivanovo, 153012 Russia


O. P. Rotar
Federal Almazov Medical Research Centre
Russian Federation
Akkuratova ul. 2, St. Petersburg, 197341 Russia


I. A. Trubacheva
Research Institute for Cardiology, Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
Kievskaya 111a, Tomsk, 634012 Russia


E. V. Shlyakhto
Federal Almazov Medical Research Centre
Russian Federation
Akkuratova ul. 2, St. Petersburg, 197341 Russia


S. A. Boytsov
State Research Center for Preventive Medicine
Russian Federation
Petroverigsky per. 10, Moscow, 101990 Russia


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For citation:


Evstifeeva S.E., Shalnova S.A., Deev A.D., Gatagonova T.M., Efanov A.Y., Zhernakova Y.V., Il'in V.A., Konradi A.O., Metelskaya V.A., Oschchepkova E.V., Romanchuk S.V., Rotar O.P., Trubacheva I.A., Shlyakhto E.V., Boytsov S.A. THE PREVALENCE OF ELEVATED LEVELS OF C-REACTIVE PROTEIN AND ITS ASSOCIATION WITH TRADITIONAL RISK FACTORS AND MORBIDITY AMONG RESIDENTS OF THE RUSSIAN FEDERATION (ACCORDING TO THE ESSE-RF STUDY). Rational Pharmacotherapy in Cardiology. 2014;10(6):597-605. (In Russ.) https://doi.org/10.20996/1819-6446-2014-10-6-19-23

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ISSN 1819-6446 (Print)
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