Preview

Rational Pharmacotherapy in Cardiology

Advanced search

Cerebrovascular Accident in a Patient with Polycythemia: a Case Report

https://doi.org/10.20996/1819-6446-2022-02-10

Abstract

Polycythemia vera is not only a clonal disease that causes hematopoietic stem cells, but also a pathology that often leads to thrombotic complications. Thrombosis can have different localization and is clinically manifested by stroke, myocardial infarction, deep vein thrombosis of the lower extremities, pulmonary embolism, thrombosis of the veins of internal organs and other conditions. One of the most formidable thrombotic complications is acute cerebrovascular accident. The heterogeneity of the possible causes of acute cerebrovascular accident requires a careful approach to differential diagnosis for timely diagnosis and individual, pathogenetically grounded selection of means of long-term antithrombotic therapy. The presented clinical case of the development of cerebrovascular accident in a patient with polycythemia vera demonstrates the importance of an informal approach to diagnosis, as well as interdisciplinary interaction for finding the true cause of the development of acute cerebrovascular accident and the appointment of pathogenetically based treatment, aimed, among other things, at the prevention of repeated episodes of acute cerebrovascular accident and others. thrombotic complications.

About the Authors

O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Oxana M. Drapkina.

Moscow.

eLibrary SPIN 4456-1297



I. I. Almazova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Ilda I. Almazova.

Moscow.

eLibrary SPIN 5486-8743



A. V. Smirnova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Anna V. Smirnova.

Moscow.

eLibrary SPIN 8743-3710



S. A. Berns
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Svetlava A. Berns.

Moscow.

eLibrary SPIN 4283-3303



R. N. Shepel
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Ruslan N. Shepel.

Moscow.

eLibrary SPIN 3115-0515



References

1. Melikyan AL, Kovrigina AM, Subortseva IN, et al. National clinical guidelines for diagnosis and therapy of Ph-negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, primary myelofibrosis) (edition 2018). Russian Journal of Hematology and Transfusiology. 2018;63(3):275-315 (In Russ.) DOI: 10.25837/HAT.2019.51.88.001.

2. Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol. 2017;92(1):94-108. DOI:10.1002/ajh.24607.

3. Abdulkadyrov KM, Shuvaev VA, Martynkevich IS. Myeloproliferative neoplasms. St. Petersburg, Moscow: Literra; 2016 (In Russ)

4. Phipps MS, Cronin CA. Management of acute ischemic stroke. BMJ. 2020;368:l6983. DOI:10.1136/bmj.l6983.

5. Roitman EV, Shabalina AA, Tanashyan MM. Formalised assessment of systemic thrombo-genicity in patients with Polycythemia vera suffered an ischemic stroke. Atherothrombosis. 2020;(2):105-14 (In Russ.) DOI:10.21518/2307-1109-2020-2-105-114.

6. Tefferi A, Vardiman J. Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008;22(1):14-22. DOI:10.1038/sj.leu.2404955.

7. Abdulkadyrov KM, Shuvaev VA, Martynkevich IS. All we know about polycythemia vera: literature review and own experience. Oncohematology. 2015;10(3):28-42 (In Russ.) DOI:10.17650/1818-8346-2015-10-3-28-42.


Review

For citations:


Drapkina O.M., Almazova I.I., Smirnova A.V., Berns S.A., Shepel R.N. Cerebrovascular Accident in a Patient with Polycythemia: a Case Report. Rational Pharmacotherapy in Cardiology. 2022;18(1):79-84. (In Russ.) https://doi.org/10.20996/1819-6446-2022-02-10

Views: 311


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)