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The Scale of Quantitative Assessment Adherence to Treatment «QAA-25»: Updating of Formulations, Constructive and Factor Validity and a Measure of Consent

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Aim: To update the definitions of selected questions of the "QAA-25" (quantitative adherence assessment) scale and evaluate it according to the criteria of validity and measure of agreement.

Materials and Methods. In a descriptive cross-sectional study including 200 patients with coronary heart disease, adherence was determined using traditional and alternative versions of selected questions of the QAA-25 scale, followed by assessment of construct validity, factor validity, and measure of agreement.

Results. Alternative question versions did not significantly affect test results, with 81% of respondents in the outpatient sample and 69% in the inpatient sample rating them as "more acceptable." The QAA-25 scale has good construct and internal validity (α – 0.818, αst – 0.832), with moderate agreement (κ – 0.562) and demonstrates high reliability of internal validity – when scale items are consistently excluded, α values remain in the 0.801-0.839 range.

Conclusion. The QAA-25 scale with modified question definitions should be used instead of the previous version of the scale. Good construct validity and factor validity, sufficient measure of agreement and specificity, high sensitivity and reliability of the QAA-25 scale allow to recommend it as a tool for assessing adherence to drug therapy, medical support, lifestyle modification and integral adherence to treatment in scientific and clinical practice.

About the Authors

N. A. Nikolaev
Omsk State Medical University
Russian Federation

Nikolai A. Nikolaev.


eLibrary SPIN 8807-9519

Yu. P. Skirdenko
Omsk State Medical University; National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Yulia P. Skirdenko.

Omsk; Moscow.

eLibrary SPIN 6719-2581

A. A. Balabanova
Tyumen Cardiology Research Center – a branch of the Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

Anastasia A. Balabanova.


A. V. Gorbenko
Omsk State Medical University
Russian Federation

Alexander V. Gorbenko.


eLibrary SPIN 4224-5951

K. A. Andreev
Omsk State Medical University
Russian Federation

Kirill A. Andreev.


eLibrary SPIN 6119-9945

M. M. Fedorin
Omsk State Medical University
Russian Federation

Maxim M. Fedorin.


eLibrary SPIN 4393-5095

M. A. Livzan
Omsk State Medical University
Russian Federation

Maria A. Livzan.


eLibrary SPIN 1961-4082

E. V. Chebanenko
Scientific and Production Company Limited Liability Company "Acoustic Control Systems"
Russian Federation

Evgeny V. Chebanenko.


eLibrary SPIN 3904-5748

G. M. Usov
Omsk State Medical University
Russian Federation

Grigory M. Usov.


eLibrary SPIN 4027-9379


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For citation:

Nikolaev N.A., Skirdenko Yu.P., Balabanova A.A., Gorbenko A.V., Andreev K.A., Fedorin M.M., Livzan M.A., Chebanenko E.V., Usov G.M. The Scale of Quantitative Assessment Adherence to Treatment «QAA-25»: Updating of Formulations, Constructive and Factor Validity and a Measure of Consent. Rational Pharmacotherapy in Cardiology. 2021;17(6):845-852.

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)