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Plasma Level’s of Neuregulin-1 in Healthy People

https://doi.org/10.20996/1819-6446-2021-11-01

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Abstract

Aim. To determine the median levels of neuregulin-1 (NRG-1; endothelium-derived growth factor and the natural agonist of the ERBB3 and ERBB4 receptors) NRG-1 in healthy volunteers and to study the associations of NRG-1 levels with gender and age.

Material and Methods. Ninety seven healthy participants were enrolled (median age of 44 [32-54], men 45 men [46.4%]). The following age groups were identified: 20-29 y.о. (n=20, men – 50.0%),  30-39  y.о.  (n=21,  men  –  52.4%),  40-49  y.о.  (n=22,  men  –  45.5%),  50-59  y.о. (n=22, men – 36.4%); 60-69 y.о. (n=12, men – 50.0%). Peripheral blood samples were collected at the time of enrolment, standard laboratory tests were performed, and NRG-1 levels were determined in the plasma samples by ELISA.

Results. In the cohort of 97 healthy participants the median value of NRG-1 was 0.3 [0.121-2.24] ng/ml. NRG-1 levels did not differ significantly between men and women (p=0.145), indicating that NRG-1 levels are not influenced by gender. The levels of NRG-1 were similar in the different age groups: age 20-29 years=0.26 [0.17-0.37] ng/ml; age 30-39=0.24 [0.1-0.39] ng/ml; age 40-49=0.31 [0.19-1.15] ng/ml; age 50-59=0.37  [0.19-1.0] ng/ml; age 60-69=0.4 [0.13-0.81] ng/ml. Correlation analysis between NRG-1 levels and route blood measurements (haemoglobin, lipids, glucose, creatinine, and uretic acid) did not show significant associations.

Conclusions. In this study, the median value of NRG-1 plasma levels were determined. The results of the study show that age and gender had no influence on NRG-1 values.

About the Authors

K. A. Zhbanov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Konstantin A. Zhbanov.

Moscow.



A. A. Shchendrygina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anastasia A. Shchendrygina.

Moscow.



E. A. Zheleznykh
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena A. Zheleznykh.

Moscow.



E. V. Privalova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena V. Privalova.

Moscow.



A. Y. Suvorov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexander Y. Suvorov.

Moscow.



A. S. Ablyametova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Avasherfe S. Ablyametova.

Moscow.



N. F. Fuksman
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Nelli F. Fuksman.

Moscow.



E. Yu. Salakheeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Ekaterina Yu. Salakheeva.

Moscow.



Yu. N. Belenkov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Yuri N. Belenkov.

Moscow.



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Review

For citation:


Zhbanov K.A., Shchendrygina A.A., Zheleznykh E.A., Privalova E.V., Suvorov A.Y., Ablyametova A.S., Fuksman N.F., Salakheeva E.Yu., Belenkov Yu.N. Plasma Level’s of Neuregulin-1 in Healthy People. Rational Pharmacotherapy in Cardiology. 2021;17(6):853-859. https://doi.org/10.20996/1819-6446-2021-11-01

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)