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Rational Pharmacotherapy in Cardiology

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Relationship between Chemotherapy and Atrial Fibrillation: Clinical Case

https://doi.org/10.20996/1819-6446-2021-10-17

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Abstract

The aim of this article is to represent the characterization of the clinical case of chemotherapy-related atrial fibrillation (AF) development in the young woman, elaborated as a result of multiple neoadjuvant and adjuvant modes of the intake of chemotherapy (both anthracycline based and non-anthracycline ones). In this case, the noted disturbances of heart rhythm should be recognized as a manifestation of cardiotoxicity. The latter implies the degree of detrimental effect of chemotherapeutical medication on the morphophynctional parameters of the cardiovascular system. Anthracycline drugs, being highly effective chemotherapytical agents, provide well-known toxic effects on the heart and vessels. Anthracycline mediated cardiotoxicity is a well- known veracity that dates back to the 60s of the last century, but up to now this medication sustains irreplaceable components of big volume of chemotherapy modes. Moreover, it should be noted that relatively newer drugs also posses certain cardiotoxicogenic potential.

About the Authors

A. A. Avagimyan
Yerevan State Medical University after M. Heratsi
Armenia

Ashot A. Avagimyan

Yerevan



L. H. Mkrtchyan
Yerevan State Medical University after M. Heratsi
Armenia

Lusine H. Mkrtchyan

Yerevan



A. A. Gevorkyan
Yerevan State Medical University after M. Heratsi
Armenia

Astgik A. Gevorkyan

Yerevan



N. B. Kononchuk
Minsk City Clinical Hospital of Emergency Care
Belarus

Natalia B. Kononchuk



L. V. Kakturskiy
Research Institute of Human Morphology
Russian Federation

Lev V. Kakturskiy

Moscow



Z. T. Djndoyan
Yerevan State Medical University after M. Heratsi
Armenia

Zinaida T. Djndoyan

Yerevan



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For citation:


Avagimyan A.A., Mkrtchyan L.H., Gevorkyan A.A., Kononchuk N.B., Kakturskiy L.V., Djndoyan Z.T. Relationship between Chemotherapy and Atrial Fibrillation: Clinical Case. Rational Pharmacotherapy in Cardiology. 2021;17(5):785-791. (In Russ.) https://doi.org/10.20996/1819-6446-2021-10-17

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)