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Evaluation of the Influence of CYP2C9* 2, CYP2C9*3 Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery

https://doi.org/10.20996/1819-6446-2021-08-12

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Abstract

Aim. The aim of the study was to evaluate the efficacy and safety of ketoprofen as an analgesic therapy in patients with CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910 gene polymorphisms after cardiac surgery.

Material and methods. The study included 90 patients. Postoperative analgesia was perfomed by ketoprofen 100 mg intramuscularly twice daily. The evaluation of pain was determined daily by Numeric Rating Scale for 5 days after cardiac surgery. The safety of ketoprofen was determined by assessing the severity of gastroenterological symptoms using the Gastrointestinal Symptom Rating Scale questionnaire and determining the frequency of episodes of acute kidney injury. The material for DNA was venous blood. To determine the single nucleotide genetic polymorphisms CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910, the real-time polymerase chain reaction was used.

Results. In patients with the AA genotype of CYP2C9*3 polymorphism, the intensity of pain on the numeric rating scale scale (points) was significantly higher than in patients with the AC genotype: 7 [6; 8] vs 6 [5; 6] (р=0,003), 7 [6; 8] vs 6 [5; 6] (р=0,04), 6 [5; 7] vs 5 [4; 5] (р=0,04), 5 [3; 6] vs 3 [3; 4] points (р=0,02) on days 1, 2, 3 and 5 of the postoperative period, respectively. The severity of gastroenterological symptoms was higher in patients with a heterozygous CT genotype for the allelic variant CYP2C9*2 than in patients with a wild CС genotype and amounted to 19 [19; 22] vs 18 [16; 20] points, respectively, (p=0,04). The distribution of genotypes for CYP2C9*2 polymorphisms and CYP2C9*3 polymorphisms between the groups of acute renal injury did not differ significantly.

Conclusion. Associations of polymorphisms CYP2C9*3 with a lower intensity of pain syndrome and CYP2C9*2 with a greater severity of gastroenterological symptoms were revealed.

About the Authors

T. E. Morozova
I.M. Sechenov First Moscow State Medical University
Russian Federation

Tatiana E. Morozova

eLibrary  SPIN  7917-1951

Moscow



D. A. Shatsky
I.M. Sechenov First Moscow State Medical University
Russian Federation

Dmitry A. Shatsky

Moscow



N. V. Shikh
I.M. Sechenov First Moscow State Medical University
Russian Federation

Nadezhda V. Shikh

eLibrary SPIN 4950-7164

Moscow



E. V. Shikh
I.M. Sechenov First Moscow State Medical University
Russian Federation

Evgeniya V. Shikh

eLibrary SPIN 2397-8414

Moscow



T. B. Andrushchyshina
I.M. Sechenov First Moscow State Medical University
Russian Federation

Tatiana B. Andrushchyshina

eLibrary  SPIN  7738-6523

Moscow



M. V. Lukina
I.M. Sechenov First Moscow State Medical University
Russian Federation

Maria V. Lukina

eLibrary SPIN 4570-607

Moscow

 



A. A. Kachanova
Russian Medical Academy of Continuing Professional Education
Russian Federation

Anastasia A. Kachanova

eLibrary SPIN 1214-8156

Moscow



Zh. A. Sozaeva
Russian Medical Academy of Continuing Professional Education
Russian Federation

Zhannet A. Sozaeva

eLibrary SPIN 4138-4466

Moscow



G. N. Shuev
Russian Medical Academy of Continuing Professional Education
Russian Federation

Grigorii N. Shuev

 eLibrary SPIN 4172-1330

Moscow



N. P. Denisenko
Russian Medical Academy of Continuing Professional Education
Russian Federation

Natalia P. Denisenko

eLibrary  SPIN  5883-6249

Moscow



E. A. Grishina
Russian Medical Academy of Continuing Professional Education
Russian Federation

Elena A. Grishina

eLibrary SPIN 3357-3591

Moscow



D. A. Sychev
Russian Medical Academy of Continuing Professional Education
Russian Federation

Dmitry A. Sychev

eLibrary SPIN 4525-7556

Moscow



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For citation:


Morozova T.E., Shatsky D.A., Shikh N.V., Shikh E.V., Andrushchyshina T.B., Lukina M.V., Kachanova A.A., Sozaeva Z.A., Shuev G.N., Denisenko N.P., Grishina E.A., Sychev D.A. Evaluation of the Influence of CYP2C9* 2, CYP2C9*3 Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery. Rational Pharmacotherapy in Cardiology. 2021;17(4):570-575. (In Russ.) https://doi.org/10.20996/1819-6446-2021-08-12

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ISSN 1819-6446 (Print)
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