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Rational Pharmacotherapy in Cardiology

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Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches

https://doi.org/10.20996/1819-6446-2021-05-01

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Abstract

Heart failure with preserved ejection fraction (HFpEF) is a syndrome associated with high morbidity and mortality rates. Little progress has been in the treatment of this condition since its introduction some 30 years ago. It's accepted that HFpEF is heterogeneous in many ways, ethologically and phenotypically. The underlying mechanisms of the syndrome are not clear. Recently, it has been shown that the diagnostic criteria for HFpEF lacks sensitivity and specificity. Novel treatment approaches, which were developed based on current HFpEF pathophysiological concepts, did not show either clinical or prognostic benefit for patients. Therefore, there is an urgent need to revise current diagnostic approaches and to further investigate the underlying mechanisms. Recently, two novel diagnostic score systems were proposed: H2PEF and HFA-PEFF. Recently, a number of phase II and III randomized control trials have been completed. Here, the authors discuss the potential novel diagnostic approaches to HFpEF and treatment perspectives.

About the Authors

A. A. Shchendrygina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anastasia A. Shchendrygina - eLibrary SPIN: 2137-5623



K. A. Zhbanov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Konstantin A. Zhbanov



E. V. Privalova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena V. Privalova



A. O. Yusupova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alfiya O. Yusupova



Yu. A. Danilogorskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Yulia A. Danilogorskaya



E. Yu. Salakheeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Ekaterina Yu. Salakheeva



I. Ya. Sokolova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Irina Ya. Sokolova



S. A. Tsatsurova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Sabrina A. Tsatsurova



A. A. Ageeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anastasia A. Ageeva



Yu. N. Belenkov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Yuri N. Belenkov



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For citation:


Shchendrygina A.A., Zhbanov K.A., Privalova E.V., Yusupova A.O., Danilogorskaya Yu.A., Salakheeva E.Yu., Sokolova I.Ya., Tsatsurova S.A., Ageeva A.A., Belenkov Yu.N. Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches. Rational Pharmacotherapy in Cardiology. 2021;17(3):476-483. (In Russ.) https://doi.org/10.20996/1819-6446-2021-05-01

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