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The “Inverse” Seasonal Blood Pressure Variability Phenotype

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The seasonal blood pressure variability (BPV) is known to demonstrate a typical winter peak. Recently, more attention is paid to the opposite situation: the summer BP levels being higher than those in winter. This phenomenon is called inverse BPV. The present article summarizes recent data on this topic. The data of the HOMED-BP project, as well as the results of the original prospective study in 770 hypertensive patients from two Russian Federation regions (mean follow-up duration 6.4 years), were used. According to the preliminary knowledge, the prevalence of inverse BPV in hypertensive patients is relatively high (15-25%). This phenomenon is more typical for treated patients, particularly for those on combination therapy, and is associated with beta-blocker intake. Higher duration of hypertension and higher levels of some risk factors (smoking) characterize the patients with inverse BPV. According to the HOMED-BP data, patients with inverse BPV had the highest overall cardiovascular risk (hazard ratio in comparison with the reference group of “minimal” “normal” BPV was 3.07; p=0.004). In summary, inverse BPV is a potentially unfavorable BP phenotype. However, its reproducibility and prospective value deserve further investigation. The absolute magnitude of seasonal BPV in these patients, calculated using different BP measurement methods, warrants special attention.

About the Authors

V. M. Gorbunov
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Vladimir M. Gorbunov - eLibrary SPIN 5111-1303


M. I. Smirnova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Marina I. Smirnova


Y. N. Koshelyaevskaya
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Yana N. Koshelyaevskaya - eLibrary SPIN 8660-0502


N. N. Panueva
Ivanovo State Medical Academy
Russian Federation

Natalya N. Panueva - eLibrary SPIN 4098-3522

N. V. Furman
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Nikolai V. Furman

P. V. Dolotovskaya
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Polina V. Dolotovskaya - eLibrary SPIN 8240-2328


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For citation:

Gorbunov V.M., Smirnova M.I., Koshelyaevskaya Ya.N., Panueva N.N., Furman N.V., Dolotovskaya P.V. The “Inverse” Seasonal Blood Pressure Variability Phenotype. Rational Pharmacotherapy in Cardiology. 2021;17(3):470-475. (In Russ.)

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