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Ability of Evaluation Coronary Calcium Index Based on Ultra-Low-Dose Computed Tomography Used in Moscow Lung Cancer Screening Project

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Aim. Determination of the possibility of reliable quantitative assessment of the coronary calcium index based on ultra-low-dose computed tomography (ultra-LDCT) which used in Moscow Lung Cancer Screening project.

Material and methods. The study included the results of 254 ultra-LDCT studies conducted as part of the Moscow lung cancer screening project. For compare the parameters of coronary calcium on different images used 16 pairs of ultra-LDCT images with a slice thickness of 1 mm and CT images with a slice thickness of 3 mm, performed without ECG synchronization, performed with an interval of less than 10 days, as well as 18 pairs of ultra-LDCT with a slice thickness of 1 mm and CT with ECG synchronization with a slice thickness of 3 mm, performed on the same day after execution. Analysis of DICOM 3.0 standard images was performed. Quantitative indicators of coronary calcium in patients from lung cancer screening were analyzed, a comparative analysis of the calcium index for Agatstone, Volume, Mass, and using the CAC-DRS scale (assessment of the degree of calcification by scores from 0 to 3 and the number of affected arteries from 0 to 4 points) was performed.

Results. Evaluation ultra-LDCT with a slice thickness in 1 mm and with a CT scan with slice thickness in 3 mm with and without ECG-synchronization for the presence of coronary calcium, and subsequent rating according to the index Agatston, Volume, Mass, as the total coronary calcium and for each coronary artery (right, left, left descending, left circumflex) received the complete data correlation (Pearson's - 1), with full correlation (Spearman's >0.9), with good rank correlations (>0,9). Compare qualitative (CAC-DRS V) and quantitative (CAC-DRS A) estimates on ultra-LDCT with CT with ECG synchronization in the same patients show a complete correlation of data was obtained (Pearson's formula - 1), with a complete correlation (Spearman's formula - 1).

Conclusion. Coronary calcium which detected in lung cancer screening subjects should be included in the overall decision-making process for further routing of patients (cardiologist, interventional surgeon, pulmonologist, therapist). Ultra-LDCT is a method that has high diagnostic accuracy in detecting and evaluating the prevalence of coronary calcium in comparison with standard CT with and without ECG synchronization, as demonstrated in our study. Evaluation of coronary calcium according to ultra-LDCT without ECG synchronization used in screening, preferably with a 1 mm slice thickness. Despite the fact that the gold standard is CT with ECG synchronization with a 3 mm slice thickness, the diagnostic significance of ultra-LDCT which used in lung cancer screening is high in relation to detecting coronary artery calcification.

About the Authors

A. E. Nikolaev
Research and Practical Clinical center for Diagnostics and Telemedicine Technologies
Russian Federation

Aleksandr E. Nikolaev - eLibrarySPIN 1320-1651


A. N. Shapiev
Morozov Children's Clinical Hospital; Russian Children's Clinical Hospital
Russian Federation

Arsen N. Shapiev - eLibrary SPIN 1662-0349


O. A. Korkunova
Research and Practical Clinical center for Diagnostics and Telemedicine Technologies
Russian Federation

Olga A. Korkunova - eLibrary SPIN 6879-129


G. Z. Mukhutdinova
Pirogov Russian National Research Medical University
Russian Federation

Guzel Z. Mukhutdinova - eLibrary SPIN 5568-0859


P. V. Tkacheva
Pirogov Russian National Research Medical University
Russian Federation

Polina V. Tkacheva - eLibrary SPIN 7190-7661


M. M. Suleymanova
Central State Medical Academy of the Administrative Department of the President of the Russian Federation
Russian Federation

Maria M. Suleymanova - eLibrary SPIN 7193-6122


A. N. Shapieva
Petrovsky National Research Centre of Surgery
Russian Federation

Albina N. Shapieva - eLibrary SPIN 4142-0162


D. M. Ramazanova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Dzhavagil M. Ramazanova - eLibrary SPIN 1525-9777


M. N. Rzayev
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Mikayil N. Rzayev - eLibrary SPIN 3695-4160


V. A. Gombolevsky
Research and Practical Clinical center for Diagnostics and Telemedicine Technologies
Russian Federation

Viktor A. Gombolevskij - eLibrary SPIN 6810-3279



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For citation:

Nikolaev A.E., Shapiev A.N., Korkunova O.A., Mukhutdinova G.Z., Tkacheva P.V., Suleymanova M.M., Shapieva A.N., Ramazanova D.M., Rzayev M.N., Gombolevsky V.A. Ability of Evaluation Coronary Calcium Index Based on Ultra-Low-Dose Computed Tomography Used in Moscow Lung Cancer Screening Project. Rational Pharmacotherapy in Cardiology. 2021;17(3):414-422. (In Russ.)

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