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Ability of Evaluation Coronary Calcium Index Based on Ultra-Low-Dose Computed Tomography Used in Moscow Lung Cancer Screening Project

https://doi.org/10.20996/1819-6446-2021-06-18

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Abstract

Aim. Determination of the possibility of reliable quantitative assessment of the coronary calcium index based on ultra-low-dose computed tomography (ultra-LDCT) which used in Moscow Lung Cancer Screening project.

Material and methods. The study included the results of 254 ultra-LDCT studies conducted as part of the Moscow lung cancer screening project. For compare the parameters of coronary calcium on different images used 16 pairs of ultra-LDCT images with a slice thickness of 1 mm and CT images with a slice thickness of 3 mm, performed without ECG synchronization, performed with an interval of less than 10 days, as well as 18 pairs of ultra-LDCT with a slice thickness of 1 mm and CT with ECG synchronization with a slice thickness of 3 mm, performed on the same day after execution. Analysis of DICOM 3.0 standard images was performed. Quantitative indicators of coronary calcium in patients from lung cancer screening were analyzed, a comparative analysis of the calcium index for Agatstone, Volume, Mass, and using the CAC-DRS scale (assessment of the degree of calcification by scores from 0 to 3 and the number of affected arteries from 0 to 4 points) was performed.

Results. Evaluation ultra-LDCT with a slice thickness in 1 mm and with a CT scan with slice thickness in 3 mm with and without ECG-synchronization for the presence of coronary calcium, and subsequent rating according to the index Agatston, Volume, Mass, as the total coronary calcium and for each coronary artery (right, left, left descending, left circumflex) received the complete data correlation (Pearson's - 1), with full correlation (Spearman's >0.9), with good rank correlations (>0,9). Compare qualitative (CAC-DRS V) and quantitative (CAC-DRS A) estimates on ultra-LDCT with CT with ECG synchronization in the same patients show a complete correlation of data was obtained (Pearson's formula - 1), with a complete correlation (Spearman's formula - 1).

Conclusion. Coronary calcium which detected in lung cancer screening subjects should be included in the overall decision-making process for further routing of patients (cardiologist, interventional surgeon, pulmonologist, therapist). Ultra-LDCT is a method that has high diagnostic accuracy in detecting and evaluating the prevalence of coronary calcium in comparison with standard CT with and without ECG synchronization, as demonstrated in our study. Evaluation of coronary calcium according to ultra-LDCT without ECG synchronization used in screening, preferably with a 1 mm slice thickness. Despite the fact that the gold standard is CT with ECG synchronization with a 3 mm slice thickness, the diagnostic significance of ultra-LDCT which used in lung cancer screening is high in relation to detecting coronary artery calcification.

About the Authors

A. E. Nikolaev
Research and Practical Clinical center for Diagnostics and Telemedicine Technologies
Russian Federation

Aleksandr E. Nikolaev - eLibrarySPIN 1320-1651

Moscow



A. N. Shapiev
Morozov Children's Clinical Hospital; Russian Children's Clinical Hospital
Russian Federation

Arsen N. Shapiev - eLibrary SPIN 1662-0349

Moscow



O. A. Korkunova
Research and Practical Clinical center for Diagnostics and Telemedicine Technologies
Russian Federation

Olga A. Korkunova - eLibrary SPIN 6879-129

Moscow



G. Z. Mukhutdinova
Pirogov Russian National Research Medical University
Russian Federation

Guzel Z. Mukhutdinova - eLibrary SPIN 5568-0859

Moscow



P. V. Tkacheva
Pirogov Russian National Research Medical University
Russian Federation

Polina V. Tkacheva - eLibrary SPIN 7190-7661

Moscow



M. M. Suleymanova
Central State Medical Academy of the Administrative Department of the President of the Russian Federation
Russian Federation

Maria M. Suleymanova - eLibrary SPIN 7193-6122

Moscow



A. N. Shapieva
Petrovsky National Research Centre of Surgery
Russian Federation

Albina N. Shapieva - eLibrary SPIN 4142-0162

Moscow



D. M. Ramazanova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Dzhavagil M. Ramazanova - eLibrary SPIN 1525-9777

Moscow



M. N. Rzayev
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Mikayil N. Rzayev - eLibrary SPIN 3695-4160

Moscow



V. A. Gombolevsky
Research and Practical Clinical center for Diagnostics and Telemedicine Technologies
Russian Federation

Viktor A. Gombolevskij - eLibrary SPIN 6810-3279

Moscow



References

1. Chazova IE; Oschepkova EV. The fight against cardiovascular diseases: problems and solutions at the present stage. Vestnik Roszdravnadzora. 2015;5:7-10 (In Russ.)

2. Shelyakina PA; Margaryan AR; Sergeeva VS; et al. Prevalence of risk factors for cardiovascular diseases in students v. Molodezhny'j Innovacionny'j Vestnik. 2018;7(S1):101-2 (In Russ.)

3. Arcadi T; Maffei E; Sverzellati N; et al. Coronary artery calcium score on low-dose computed tomography for lung cancer screening. World J Radiol. 2014;6(6):381-7. DOI:10.4329/wjrv6.i6.381.

4. Chiles C; Duan F; Gladish G; et al. Association of coronary artery calcification and mortality in the National Lung Screening Trial: A comparison of three scoring methods. Radiology 2015; 276(1):82-90. DOI:10.1148/radiol.15142062.

5. Azour L; Kadoch M; Ward T; et al. Estimation of cardiovascular risk on routine chest CT: Ordinal coronary artery calcium scoring as an accurate predictor of Agatston score ranges. Journal of Cardiovascular Computed Tomography 2016;11(1):8-15. DOI:10.1016/j.jcct.2016.10.001.

6. Watts JRJ; Sonavane SK; Snell-Bergeon J; et al. Visual scoring of coronary artery calcification in lung cancer screening computed tomography: Association with all-cause and cardiovascular mortality risk. Coron Artery Dis. 2015;26:1 57-62. DOI:10.1097/MCA.0000000000000189.

7. Nikolaev AE; Shapiev AN; Ramazanova DM; et al. New approaches for assessing coronary changes in multi-layer spiral computed tomography. Russian Journal of Cardiology 2019;24(12):124-30 (In Russ.) DOI:10.15829/1560-4071-2019-12-124-130].

8. Greenland P; Blaha MJ; Budoff MJ; et al. Coronary Calcium Score and Cardiovascular Risk. J Am Coll Cardiol. 2018;72(4):434-47. DOI:10.1016/j.jacc.2018.05.027.

9. Bahtiguzin RR; Nikolaeva EV; Vorobyeva AA; et al. The diagnostics of coronary atherosclerosis with the help of speedy 64-spiral computer tomography Астраханский Медицинский Журнал. 2010;5(1):63-6 (In Russ.)

10. Arkhipova IM; Mershina EA; Sinitsyn VE. The role of CT coronary angiography in the diagnosis of coronary artery disease on an outpatient basis. Polyclinic. 2013;3-1:18-21 (In Russ.)

11. Simonenko VB; Ekimovskikh AYu; Dolbin IV. Calcification of the coronary arteries - the current state of the problem. Clinical Medicine. 2013;91(4):11-5 (In Russ.)

12. Sinitsyn VE; Ternovoy SK. The role of coronary artery CT angiography from a practical point of view: where are we today? Creative Cardiology 2007;1-2:25-31 (In Russ.)

13. Blair KJ; Allison MA; Morgan C; et al. Comparison of ordinal versus Agatston coronary calcification scoring for cardiovascular disease mortality in community-living individuals. Int J Cardiovasc Imaging. 2014;30(4):813-8. DOI:10.1007/s10554-014-0392-1.

14. Hughes-Austin JM; Dominguez A; Allison MA; et al. Relationship of Coronary Calcium on Standard Chest CT Scans With Mortality JACC Cardiovasc. Imaging. 2016;9(2):152-9. DOI:10.1016/j.jcmg.2015.06.030.

15. Kim SM; Chung MJ; Lee KS; et al. Coronary calcium screening using low-dose lung cancer screening: effectiveness of MDCT with retrospective reconstruction. Am J Roentgenol. 2008;1 90:91 7-22. DOI:10.2214/AJR.07.2979.

16. National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking — 50 Years of Progress: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US) 2014. PMID:24455788.

17. Pakdaman MN; Rozanski A; Berman DS. Incidental coronary calcifications on routine chest CT: Clinical implications. Trends Cardiovasc Med. 2017;27:475-80. DOI:10.1016/j.tcm.2017.04.004

18. Takahashi EA; Koo CW; White DB; Lindell RM. Prospective Pilot Evaluation of Radiologists and Computer-aided Pulmonary Nodule Detection on Ultra-low-Dose CT With Tin Filtration. J Thorac Imaging. 2018;33(6):396-401. DOI:10.1097/RTI.0000000000000348.

19. Zanon M; Pacini GS; de Souza VVS; Marchiori E. Early detection of lung cancer using ultra-low-dose computed tomography in coronary CT angiography scans among patients with suspected coronary heart disease. Lung Cancer; 2017;114:1-5. DOI:10.1016/j.lungcan.2017.10.004.

20. Gombolevsky VA; Barchuk AA; Laipan ASh; et al. Lung Сancer Screening with Low-Dose Computed Tomography: Management and Efficiency. Radiologiya - Praktika. 2018;1(67):28-36 (In Russ.)

21. Bernheim A; Auffermann WF; Stillman AE. The dubious value of coronary calcium scoring on lung cancer screening CT JACR. 2017;14:343-4. DOI:10.1016/j.jacr.2016.08.011.

22. Jacobs PC; Gondrie MJ; van der Graaf Y et al. Coronary artery calcium can predict all-cause mortality and cardiovascular events on low-dose CT screening for lung cancer. Am J Roentgenol. 2012;1 98:50511. DOI:10.2214/AJR.10.5577.

23. Hecht HS; Cronin P; Blaha MJ; et al. Erratum to "2016 SCCT/STR guidelines for coronary artery calcium scoring of noncontrast noncardiac chest CT scans a report of the society of Cardiovascular Computed Tomography and Society of Thoracic Radiology" [J. Cardiovasc. Comput. Tomogr. 11(2017):74-84]. J Cardiovasc Comput Tomogr 2017;11(2):170. DOI:10.1016/j.jcct.2017.02.011.

24. Jacobs PC; Isgum I; Gondrie MJ; et al. Coronary artery calcification scoring in low-dose ungated CT screening for lung cancer: interscan agreement. Am J Roentgenol. 2010;1 94:1 244-49. DOI:10.2214/AJR.09.3047.

25. Wu MT; Yang P; Huang YL; et al. Coronary arterial calcification on low-dose ungated MDCT for lung cancer screening: concordance study with dedicated cardiac CT. Am J Roentgenol. 2008;190(4):923-8. DOI:10.2214/AJR.07.2974.

26. Nikolaev AE; Gombolevsky VA; Shapiev AN; et al. Random discoveries for screening lung cancer for low-dose computed tomography. Tuberculosis and Lung Dlseaseю. 2018;96(1 1):60-8 (In Russ.) DOI:10.21292/2075-1230-2018-96-11-60-67.

27. Black WC; Gareen IF; Soneji SS; et al. National Lung Screening Trial Research Team. Cost-effectiveness of CT screening in the National Lung Screening Trial. N Engl J Med. 2014;371(19):1793-802. DOI:10.1056/NEJMoa1312547.


For citation:


Nikolaev A.E., Shapiev A.N., Korkunova O.A., Mukhutdinova G.Z., Tkacheva P.V., Suleymanova M.M., Shapieva A.N., Ramazanova D.M., Rzayev M.N., Gombolevsky V.A. Ability of Evaluation Coronary Calcium Index Based on Ultra-Low-Dose Computed Tomography Used in Moscow Lung Cancer Screening Project. Rational Pharmacotherapy in Cardiology. 2021;17(3):414-422. (In Russ.) https://doi.org/10.20996/1819-6446-2021-06-18

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