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Clinical Trials Evaluating Drug Therapy: Types, Reliability of Results, Place in Modern Evidence-Based Medicine

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The article discusses the main methods of evidence in modern medicine. Special attention is paid to randomized controlled trials and observational studies. The advantages of randomized controlled trials over observational studies are considered. A comparison of the informative value of randomized controlled trials and observational studies in assessing the effect of therapeutic interventions is made. Attention is drawn to situations when conducting randomized controlled trials is not possible and when they become the main source of information. It is emphasized that in order to verify the results of randomized controlled trials in real clinical practice, it is necessary to conduct observational studies. The basic principles of conducting observational studies are considered.

About the Authors

S. Yu. Martsevich
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Sergey Yu. Martsevich - eLibrary SPIN 7908-9554


N. P. Kutishenko
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Natalia P. Kutishenko - eLibrary SPIN 7893-9865


Yu. V. Lukina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Yulia V. Lukina - eLibrary SPIN 8949-4964


M. M. Lukyanov
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Mikhail M. Lukyanov - eLibrary SPIN 6842-9870


O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Oxana M. Drapkina - eLibrary SPIN 4456-1297



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For citations:

Martsevich S.Yu., Kutishenko N.P., Lukina Yu.V., Lukyanov M.M., Drapkina O.M. Clinical Trials Evaluating Drug Therapy: Types, Reliability of Results, Place in Modern Evidence-Based Medicine. Rational Pharmacotherapy in Cardiology. 2021;17(2):249-255.

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)