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Modern trends in identification of causative agents in infective endocarditis

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Advances in the diagnosis and treatment of patients with infectious endocarditis are limited by the high frequency of cases with an unknown etiology and imperfection of microbiological (cultural) methods. To overcome these problems new approaches to the identification of infectious endocarditis pathogens were introduced, which allowed achieving certain positive results. However, it should be noted that despite the wide variety of diagnostic tools currently used, there is no ideal method for etiological laboratory diagnosis of infectious endocarditis. The article discusses the features and place of immunochemical, molecular biological (MALDI-TOF MS, real-time PCR, sequencing, in situ fluorescence hybridization, metagenomic methods, etc.), immunohistochemical methods, and their advantages and limitations.

About the Authors

E. O. Kotova
Peoples’ Friendship University of Russia (RUDN)
Russian Federation

Elizaveta O. Kotova


eLibrary SPIN 6397-6480

E. A. Domonova
Central Research Institute of Epidemiology
Russian Federation

Elvira A. Domonova


eLibrary SPIN 1781-8807

Zh. D. Kobalava
Peoples’ Friendship University of Russia (RUDN)
Russian Federation

Zhanna D. Kobalava


eLibrary SPIN 9828-5409

J. L. Karaulova
Peoples’ Friendship University of Russia (RUDN)
Russian Federation

Yuliya L. Karaulova


eLibrary SPIN 8967-1163

A. S. Pisaryuk
Peoples’ Friendship University of Russia (RUDN); Moscow City Hospital named after V.V. Vinogradov
Russian Federation

Alexandra S. Pisaryuk


eLibrary SPIN 5602-1059

A. V. Balatskiy
Lomonosov Moscow State University
Russian Federation

Alexander V. Balatsky


eLibrary SPIN 3106-1840

V. G. Akimkin
Central Research Institute of Epidemiology
Russian Federation

Vasily G. Akimkin


eLibrary SPIN 4038-7455


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For citations:

Kotova E.O., Domonova E.A., Kobalava Z.D., Karaulova J.L., Pisaryuk A.S., Balatskiy A.V., Akimkin V.G. Modern trends in identification of causative agents in infective endocarditis. Rational Pharmacotherapy in Cardiology. 2021;17(1):153-164. (In Russ.)

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