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Role of Speckle Tracking in the Evaluation of Left Ventricular Remodeling After Streptokinase Infusion in Patients with Acute Anterior Myocardial Infarction

https://doi.org/10.20996/1819-6446-2020-11-04

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Abstract

Background. Left ventricular (LV) remodeling is an adverse consequence after acute myocardial infarction.
Aim. To assess the role of speckle tracking in the evaluation of LV remodeling after streptokinase infusion in patients with acute anterior ST-segment elevation myocardial infarction (STEMI).
Material and methods. A total of 200 patients with first acute anterior STEMI received streptokinase as a reperfusion therapy were included. Conventional echocardiography and speckle tracking were performed within 3 days of admission and 3 months later. According to the development of LV remodeling, patients were classified into two groups. Group (I) patients with LV remodeling (60 patients) and group (II) patients without remodeling (140 patients).
Results. Patients with LV remodeling had lower global longitudinal (GLS) and circumferential (GCS) strain values (-13.19±4.57 vs. -18.90±4.23 % and -13.16±4.27 vs. -17.16±3.3 %, respectively, p<0.001). GLS cutoff value of >-13.5 was shown to have the best diagnostic accuracy (sensitivity =60.0% & specificity =87.1%) in predicting LV remodeling (AUC 0.816, 95% confidence interval [CI] 0.754-0.877, p<0.001). GCS cutoff value of >-16.21 was shown to have the best diagnostic accuracy (sensitivity =75.0% & specificity =71.4%) in predicting LV remodeling (AUC 0.785, 95%CI 0.719-0.85, p<0.001).
Conclusion. Speckle tracking echocardiography either longitudinal or circumferential strain has good sensitivity and specificity in predicting LV remodeling after acute myocardial infarction.

About the Authors

Sh. I. Farag
Benha University
Egypt

Shereen Ibrahim Farag - MD, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.



Kh. E. El-Rabbat
Benha University
Egypt

Khaled Emad El-Din El-Rabbat - MD, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.



M. A. El-Awadi
Benha University
Egypt

Mohamed Ali El-Awadi - MBBCH, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.



A. M. Sabry
Benha University
Egypt

AL-Shimaa Mohamed Sabry - MD, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.



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For citation:


Farag S.I., El-Rabbat K.E., El-Awadi M.A., Sabry A.M. Role of Speckle Tracking in the Evaluation of Left Ventricular Remodeling After Streptokinase Infusion in Patients with Acute Anterior Myocardial Infarction. Rational Pharmacotherapy in Cardiology. 2020;16(6):876-880. https://doi.org/10.20996/1819-6446-2020-11-04

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ISSN 1819-6446 (Print)
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