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Clinical and Pharmacological Approaches to the Prescription of Centrally Acting Antihypertensive Drugs for Uncontrolled Arterial Hypertension

https://doi.org/10.20996/1819-6446-2020-10-18

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Abstract

Episodes of rapid increase in blood pressure due to uncontrolled arterial hypertension, previously known as a hypertensive urgency, is common clinical condition which many of practicing physicians are encountered daily. As a rule, these conditions are not life-threatening, however they could lead to target-organs damage if not promptly relieved. Therefore, clear evidence-based recommendations of optimal antihypertensive drug administration in these situations would provide more safe and effective therapy. Despite that, definite expert consensus regarding optimal choice of antihypertensive drugs to manage these patients have not been reached so far. The aim of the current review was to assess the results obtained from clinical trials regarding the safety and efficacy of moxonidine for urgent hypertensive therapy in patients with uncontrolled arterial hypertension admitted to emergency healthcare units as well as in those at the prehospital stage. Performed literature-based analysis revealed enough evidences proving that moxonidine can be administered in a single dose of 0.4 mg as a drug of choice in situations where prompt and stable hypotensive effect is desired. Results of comparative studies designed to closely match real clinical settings indicate that more adequate and sustainable therapeutic effect is achieved after moxonidine administration in comparison to other frequently used antihypertensive drugs.

About the Authors

A. V. Strygin
Volgograd State Medical University
Russian Federation

Andrey V. Strygin – MD, PhD, Head of Chair of Fundamental Medicine and Biology

 Pavshikh Bortsov pl. 1, Volgograd, 400131



B. E. Tolkachev
Volgograd State Medical University; Volgograd Medical Research Centre
Russian Federation

Boris E. Tolkachev – MD, PhD, Associate Professor, Chair of Fundamental Medicine and Biology, Volgograd State Medical University; Senior Researcher, Laboratory of Clinical Pharmacology, Volgograd Medical Research Centre

 Pavshikh Bortsov pl. 1, Volgograd, 400131



A. O. Strygina
Volgograd State Medical University
Russian Federation

Anna О. Strygina – MD, Assistant, Chair of Immunology and Allergology

 Pavshikh Bortsov pl. 1, Volgograd, 400131



A. M. Dotsenko
Volgograd State Medical University; Volgograd Medical Research Centre
Russian Federation

Anna М. Dotsenko – MD, Assistant, Chair of Fundamental Medicine and Biology, Volgograd State Medical University; Researcher, Laboratory of Clinical Pharmacology, Volgograd Medical Reseach Centre

 Pavshikh Bortsov pl. 1, Volgograd, 400131



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For citation:


Strygin A.V., Tolkachev B.E., Strygina A.O., Dotsenko A.M. Clinical and Pharmacological Approaches to the Prescription of Centrally Acting Antihypertensive Drugs for Uncontrolled Arterial Hypertension. Rational Pharmacotherapy in Cardiology. 2020;16(5):815-821. (In Russ.) https://doi.org/10.20996/1819-6446-2020-10-18

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)