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Changes in Arterial Wall Stiffness in Patients with Obesity and Paroxysmal Form of Atrial Fibrillation

https://doi.org/10.20996/1819-6446-2020-08-05

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Abstract

Aim. To study changes in vascular wall stiffness in patients with obesity and paroxysmal atrial fibrillation (AF) during sinus rhythm retention.

Material and methods. The study included 86 obese patients aged 38 to 72 years. Patients were divided into 2 groups: 42 patients with paroxysmal AF and obesity (Group I) and 44 patients with obesity and without rhythm disturbance (Group II). All patients were evaluated for the main parameters of arterial wall stiffness: the heart-ankle vascular index (CAVI) and the ankle-brachial index (ABI) in the right and left main arteries.

Results. Body mass index (BMI) did not differ significantly between groups. The prevalence of visceral obesity in patients with paroxysmal AF was significantly higher than in patients without heart rhythm disorders. The study of vascular wall rigidity revealed a significant increase in the CAVI index in patients with paroxysmal AF compared with this in patients without cardiac arrhythmia. The average value of the CAVI index was 9.61±1.51 and 7.92±0.18, respectively (p=0.0003). In patients with obesity and paroxysmal AF, correlations were found between waist circumference to hip circumference (WC/HC) ratio and CAVI index (r=0.455, p=0.004); WC/height ratio and CAVI index (r=0.443, p=0.003); between WC and CAVI index (r=0.493, p=0.002). A positive direct relationship was found between CAVI index and the frequency of AF attacks during the year: r=0.782 (p=0.001).

Conclusion. A significant increase in the CAVI index, indicating a change in vascular wall stiffness, was found in patients with obesity and paroxysmal AF when compared with overweight patients without heart rhythm disorders. The increase in the CAVI index was correlated with the increase in WC, the WC/HC ratio, and WC/height ratio. There was a significant direct relationship between the CAVI index and the frequency of arrhythmia attacks in patients with obesity and paroxysmal AF.

About the Authors

V. I. Podzolkov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Valery I. Podzolkov – MD, PhD, Professor, Head of Chair of Faculty Therapy №2, Director of Therapeutic Clinic, University Clinical Hospital №4

Trubetskaya ul. 8-2, Moscow, 119991



A. I. Tarzimanova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Aida I. Tarzimanova – MD, PhD, Professor, Chair of Faculty Therapy №2

Trubetskaya ul. 8-2, Moscow, 119991



A. E. Bragina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anna E. Bragina – MD, PhD, Professor, Chair of Faculty Therapy №2

Trubetskaya ul. 8-2, Moscow, 119991



K. K. Osadchiy
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Konstantin K. Osadchiy – MD, PhD, Associate Professor, Chair of Faculty Therapy №2

Trubetskaya ul. 8-2, Moscow, 119991



R. G. Gataulin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Radik G. Gataulin – MD, Postgraduate Student, Chair of Faculty Therapy №2

Trubetskaya ul. 8-2, Moscow, 119991



K. A. Oganesyan
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Karine A. Oganesyan – MD, Head of Internal Medicine Department, University Hospital №4

Trubetskaya ul. 8-2, Moscow, 119991



N. V. Lobova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Natalia V. Lobova – MD, Physician, Internal Medicine Department, University Hospital №4

Trubetskaya ul. 8-2, Moscow, 119991



Z. B. Jafarova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Zarema B. Jafarova – MD, Head of Functional Diagnostics Department, University Hospital №4

Trubetskaya ul. 8-2, Moscow, 119991



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For citation:


Podzolkov V.I., Tarzimanova A.I., Bragina A.E., Osadchiy K.K., Gataulin R.G., Oganesyan K.A., Lobova N.V., Jafarova Z.B. Changes in Arterial Wall Stiffness in Patients with Obesity and Paroxysmal Form of Atrial Fibrillation. Rational Pharmacotherapy in Cardiology. 2020;16(4):516-521. https://doi.org/10.20996/1819-6446-2020-08-05

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ISSN 1819-6446 (Print)
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