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The Effects of Telmisartan and Its Combinations on Office Blood Pressure: Results of Prospective Observational Study TAINA

https://doi.org/10.20996/1819-6446-2020-04-07

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Abstract

Aim. To evaluate the effectiveness and safety of telmisartan, used in monotherapy or in combination with hydrochlorothiazide or amlodipine, in real clinical practice in patients with diagnosed arterial hypertension who have not reached the target levels of blood pressure (BP).

Material and methods. The study was a non-intervention, prospective, multicenter, comparative, observational, epidemiological program, which was carried out in Russian medical institutions. The total patient population in which the prescribed therapy was administered included 1933 people (758 men and 1175 women, mean age 57.0-59.3 years). Participants were followed-up for 12 weeks. The change in office BP was evaluated on the 4th and 12th week.

Results. Significant (p<0.001 in all cases) change in office BP compared with the initial data were recorded in all study groups of therapy already at 4 weeks of treatment and became even more pronounced at 12 weeks. In the telmisartan monotherapy group, BP decreased from 155.7±10.7/92.2±7.6 mm Hg to 131.4±12.1/80.8±7.3 mm Hg at the end of the 4th week and to 125.3±7.6/78.2±6.1 mm Hg – at the end of the 12th week. Similarly, after treatment with the combination of telmisartan and hydrochlorothiazide, BP decreased from 162.7±12.6/94.3±7.9 mm Hg to 133.2±12.5/81.6±8.4 mmHg at the end of the 4th week and to 126.0±7.8/78.4±6.7 mm Hg – at the end of the 12th week. In telmisartan/amlodipine group, a decrease in BP also occurred, from 162.5±13.2/94.6±8.6 mm Hg to 132.8±14.5/81.3±7.5 mm Hg on the 4th week and to 125.4±8.7/78.4±5.6 mm Hg at the end of follow up (12 weeks). The proportion of patients who reached the target BP (<140/90 mm Hg) after treatment with telmisartan as monotherapy was 91.7%, after treatment with telmisartan+hydrochlorothiazide – 89.6%, after treatment with telmisartan+amlodipine – 92.8%. Throughout the program, prescribed therapy was well tolerated by patients. During the study, 47 adverse events (AEs) were recorded in 36 patients: 31 AEs with telmisartan monotherapy, 5 AEs with telmisartan/hydrochlorothiazide combination, and 11 AEs with telmisartan/amlodipine combination. Most of the AEs registered during the trial resolved by the end of the study, in four cases the date of AEs resolve is unknown, in two cases, at the time of completion of the study, AEs continued.

Conclusion. In the TAINA study a high antihypertensive efficacy and a comparable favorable safety and tolerability profile of telmisartan, used as monotherapy and in combination with hydrochlorothiazide or amlodipine was determined.

About the Authors

O. D. Ostroumova
Russian Medical Academy of Continuous Professional Education; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Olga D. Ostroumova– MD, PhD, Professor, Head of Chair of Therapy and Polymorbid Pathology, Russian Medical Academy of Continuous Professional Education; Professor, Chair of Clinical Pharmacology and Propaedeutics of Internal Medicine, Sechenov University

Barrikadnaya ul. 2/1, Moscow, 125993,

Trubetskaya ul. 8-2, Moscow, 119991



A. I. Kochetkov
Russian Medical Academy of Continuous Professional Education
Russian Federation

Alexey I. Kochetkov – MD, PhD, Associate professor, Chair of Therapy and Polymorbid Pathology

Barrikadnaya ul. 2/1, Moscow, 125993



F. T. Ageev
National Medical Research Center of Cardiology
Russian Federation

Fail T. Ageev– MD, PhD, Professor, Head of Scientific Dispensary Department, Research Institute of Clinical Cardiology named after A.L. Myasnikov

Tretya Cherepkovskaya ul. 15A, Moscow, 121552



G. S. Anikin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Georgy S. Anikin– MD, PhD, Associate Professor, Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases

Trubetskaya ul. 8-2, Moscow, 119991



E. Kh. Akhmetzyanova
Bashkir State Medical University
Russian Federation

Elmira Kh. Akhmetzyanova– MD, PhD, Professor, Chair of Therapy and Occupational Diseases

Lenina ul. 3, Ufa, Republic of Bashkortostan, 450008



E. I. Bezuglova
City Outpatient Сlinic №5
Russian Federation

Elena I. Bezuglova– MD, Deputy Chief for Medical Part, Kursk City Polyclinic №5

Zapolnaya ul. 43A, Kursk, 305040



A. B. Bekoeva
City Consultative and Diagnostic Center №1
Russian Federation

Anzhela B Bekoeva– MD, Cardiologist

Siqueirosa ul. 10, St. Petersburg, 194354



N. Yu. Borovkova
Privolzhsky Research Medical University
Russian Federation

Natalia Yu. Borovkova– MD, PhD, Professor, Chair of Hospital Therapy named after V.G. Vogralika

Mininа and Pozharskogo ploschad 10/1, Nizhny Novgorod, 603005



N. G. Vinogradova
Privolzhsky Research Medical University
Russian Federation

Nadezhda G. Vinogradova– MD, PhD, Assistant, Chair of Internal Diseases

Mininа and Pozharskogo ploschad 10/1, Nizhny Novgorod, 603005



E. V. Gorbunova
Research Institute for Complex Issues of Cardiovascular Diseases

Elena V. Gorbunova– MD, PhD, Head of Polyclinic, Kemerovo Cardiology Dispensary; Leading Researcher, Laboratory of Cardiac Arrhythmias and Artificial Cardiac Pacemakers, Department for Diagnosis of Cardiovascular Diseases, Research Institute for Complex Issues of Cardiovascular Diseases

Sosnovy bulv. 6, Kemerovo, 650002



A. A. Goryacheva
Medical and Diagnostic Clinic “CardioVita”; Smolensk State Medical University

Anna A. Goryacheva– MD, PhD, Professor, Chair of Therapy, Ultrasound and Functional Diagnostics, Smolensk State Medical University; Chief-Physician, “KardioVita” Clinic

Novo-Kievskaya ul. 9A, Smolensk, 214018, 

Krupskoi ul. 28, Smolensk, 214019



E. S. Zhugrova
Multidisciplinary Medical Diagnostic Center “MSCh 157”

Elena S. Zhugrova– MD, PhD, Physician

Warsawskaya ul. 100, St. Petersburg, 196066



O. A. Kislyak
Pirogov Russian National Research Medical University

Oksana A. Kislyak– MD, PhD, Professor, Head of Chair of Faculty Therapy

Ostrovityanova ul. 1, Moscow, 117997



S. M. Klyashev
Tyumen State Medical University

Sergey M. Klyashev– MD, PhD, Professor, Head of Chair of Therapy with Courses of Endocrinology, Functional and Ultrasound Diagnostics

Odesskaya ul. 54, Tyumen, 625023



V. P. Kuzmin
Samara Regional Clinical Cardiology Dispensary

Vladimir P. Kuzmin– MD, PhD, Head of Consultative and Rehabilitation Department

Aerodromnaya ul. 43, Samara, 443070



A. A. Lipchenko
“New Hospital”; Ural State Medical University

Alexander A. Lipchenko – MD, PhD, Associate Professor, Chair of Therapy, Faculty of Continuing Education and Professional Retraining, Ural State Medical University; Head of Cardiology Service, “New Hospital”

Zavodskaya ul. 29, Ekaterinburg, 620109, 

Repina ul. 3, Ekaterinburg, 620028



G. V. Matyushin
Regional Clinical Hospital

Gennady V. Matyushin– MD, PhD, Professor, Сardiologist

Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022



E. A. Mikhailova
Saratov City Outpatient Clinic №2

Elena A. Mikhailova– MD, Cardiologist, Head of Cardiology Unit

Zheleznodorozhnaya ul. 61/69, Saratov, 410005



V. A. Nevzorova
Pacific State Medical University

Vera A. Nevzorova– MD, PhD, Professor, Director of Institute of Therapy and Instrumental Diagnostics

Ostryakova prosp. 2, Vladivostok, Primorsky Territory, 690002



A. G. Obrezan
International Medical Center SOGAZ; St. Petersburg State University

Andrey G. Obrezan– MD, PhD, Professor, Head of Chair of Hospital Therapy, St. Petersburg State University; Chief-Physician of Group of Clinics “Sogaz Medicine”, SOGAZ International Medical Center

Cheboksarsky per. 1/6, St. Petersburg, 191186, 

Universitetskaya nab. 7-9, St. Petersburg, 199034



T. A. Petrichko
City Outpatient Clinic №3; Institute for Advanced Training of Health Workers of the Khabarovsk Territory

Tatiana A. Petrichko– MD, PhD, Professor, Chair of General Medical Practice and Preventive Medicine, Institute for Advanced Training of Health Workers of the Khabarosvsk Territory; Head of Cardiology Department, City Polyclinic №3

Dikopoltseva ul. 34, Khabarovsk, 680000, 

Krasnodarskaya ul. 9, Khabarovsk, 680009



M. M. Petrova
Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky

Marina M. Petrova– MD, PhD, Professor, Head of Chair of Outpatient Therapy and Family Medicine

Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022



A. N. Reider
State Novosibirsk Regional Clinical Hospital

Tatiana N. Reider– MD, Head of Department of Emergency Cardiology, Regional Vascular Center №2

Nemirovicha-Danchenko ul. 130, Novosibirsk, 630087



A. N. Repin
Research Institute of Cardiology

Alexey N. Repin– MD, PhD, Professor, Head of Department of General Clinical Cardiology and Epidemiology of Cardiovascular Diseases

Kievskaya ul. 111A, Tomsk, 634012



V. I. Sadovoy
O.N. Semashko Republican Clinical Hospital

Valery I. Sadovoy– MD, PhD, Head of Department of Cardiology

Kievskaya ul. 69, Simferopol, Republic of Crimea, 295017



N. P. Sanina
M.F. Vladimirsky Moscow Regional Clinical Research Institute

Natalia P. Sanina– MD, PhD, Professor, Chair of Therapy

Schepkina ul. 61/2, Moscow, 129110



A. E. Skripchenko
Novokuznetsk City Clinical Hospital №1; Novokuznetsk State Institute of Advanced Medical Studies – Branch of Russian Medical Academy of Continuing Professional Education

Alla E. Skripchenko– MD, PhD, Associate Professor, Chair of Cardiology, Novokuznetsk State Institute of Advanced Medical Studies – Branch of Russian Medical Academy of Continuing Professional Education

Bardina pr. 28, Novokuznetsk, Kemerovo Region, 654057, 

Stroiteley prosp. 5, Novokuznetsk, Kemerovo Region, 654005



R. I. Stryuk
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Raisa I. Stryuk– MD, PhD, Professor, Head of Chair of Propaedeutics of Internal Diseases and Rheumatology, Faculty of Dentistry

Delegatskaya ul. 20/1, Moscow, 127423



I. V. Faiyance
Regional Clinical Cardiology Dispensary

Irina V. Faiyance– MD, Head of Cardiology Department №2

Prigorodnaya ul. 224a, Stavropol, 355026



L. A. Khaisheva
Rostov State Medical University

Larisa A. Khaisheva– MD, PhD, Professor, Chair of Internal Medicine №4

Suvorova ul. 119, Rostov-on-Don, 344022



N. R. Khasanov
Kazan State Medical University

Niyaz R. Khasanov– MD, PhD, Professor, Head of Chair of Propaedeutics of Internal Diseases named after Prof. S.S. Zimnitsky

Butlerova ul. 54, Kazan, 420012



R. A. Khokhlov
Voronezh Regional Clinical Hospital №1.

Roman A. Khokhlov– MD, Head of Regional Cardiology Clinic

Moskovsky prosp. 151, Voronezh, 394066



E. E. Tsareva
Voronezh Regional Clinical Hospital №1.

Elena E. Tsareva– MD, Cardiologist, Cardiac Surgeon

Moskovsky prosp. 151, Voronezh, 394066



A. L. Cherkashina
Irkutsk Regional Clinical Hospital

Anna L. Cherkashina– MD, PhD, Head of Cardiology Department

Karla Marksa ul. 29, Irkutsk, 664003


I. I. Shaposhnik
South-Ural State Medical University

Igor I. Shaposhnik – MD, PhD, Professor, Head of Chair of Propaedeutics of Internal Diseases

Vorovskogo ul. 64, Chelyabinsk, 454092



I. A. Shelestova
Prof. S.V. Ochapovsky Research Institute – Regional Clinical Hospital №1

Inga A. Shelestova– MD, PhD, Deputy Chief-Physician for Outpatient Work

1 Maya ul. 167, Krasnodar, 350086



R. N. Shepel
National Medical Research Center for Therapy and Preventive Medicine

Ruslan N. Shepel– MD, Head of Department of Organizational and Methodological Management and Analysis of Quality of Medical Care

Petroverigsky per. 10, Moscow, 101990



E. V. Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Evgenia V. Shikh– MD, PhD, Professor, Head of Chair of Clinical Pharmacology and Propaedeutics of Internal Medicine, Director of Institute of Professional Education

Trubetskaya ul. 8-2, Moscow, 119991



D. A. Yakhontov
Novosibirsk Regional Clinical Cardiology Dispensary; Novosibirsk State Medical University

Davyd A. Yakhontov– MD, PhD, Professor, Chair of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine, Novosibirsk State Medical University; Cardiologist, Novosibirsk Regional Clinical Cardiology Dispensary

Zalesskogo ul. 6, Novosibirsk, 630047, 

Krasniy prosp. 52, Novosibirsk, 630091



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For citation:


Ostroumova O.D., Kochetkov A.I., Ageev F.T., Anikin G.S., Akhmetzyanova E.K., Bezuglova E.I., Bekoeva A.B., Borovkova N.Yu., Vinogradova N.G., Gorbunova E.V., Goryacheva A.A., Zhugrova E.S., Kislyak O.A., Klyashev S.M., Kuzmin V.P., Lipchenko A.A., Matyushin G.V., Mikhailova E.A., Nevzorova V.A., Obrezan A.G., Petrichko T.A., Petrova M.M., Reider A.N., Repin A.N., Sadovoy V.I., Sanina N.P., Skripchenko A.E., Stryuk R.I., Faiyance I.V., Khaisheva L.A., Khasanov N.R., Khokhlov R.A., Tsareva E.E., Cherkashina A.L., Shaposhnik I.I., Shelestova I.A., Shepel R.N., Shikh E.V., Yakhontov D.A. The Effects of Telmisartan and Its Combinations on Office Blood Pressure: Results of Prospective Observational Study TAINA. Rational Pharmacotherapy in Cardiology. 2020;16(2):175-190. (In Russ.) https://doi.org/10.20996/1819-6446-2020-04-07

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)