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Atrial Fibrillation: Development Mechanisms, Approaches and Prospects of Therapy

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Atrial fibrillation (AF) is the most common arrhythmia. It is diagnosed in more than 33 million people worldwide and is the leading cause of hospitalization for arrhythmias. AF is characterized by fast and irregular atrial activation without discrete P-waves at a surface electrocardiography. AF pathophysiological mechanisms are very complex and include the dynamic interaction between arrhythmia substrate and triggers. Consequently, the clinical search for effective therapeutic targets should include the entire process of the onset and progression of the disease: from the first paroxysms to the development of a stable permanent form of AF.

About the Authors

O. V. Sapelnikov

Russian Federation

Oleg V. Sapelnikov – MD, PhD, Head of Laboratory of Interventional Treatment of Heart Rhythm Disorders, Department of Cardiovascular Surgery


A. A. Kulikov
National Medical Research Center of Cardiology
Russian Federation

Aleksey A. Kulikov – Junior Researcher, Department of Cardiovascular Surgery

Tretya Cherepkovskaya 15а, Moscow, 121552

D. I. Cherkashin
National Medical Research Center of Cardiology
Russian Federation

Dmitry I. Cherkashin – MD, PhD, Cardiovascular Surgeon, Department of Cardiovascular Surgery

Tretya Cherepkovskaya 15а, Moscow, 121552

I. R. Grishin
National Medical Research Center of Cardiology
Russian Federation

Igor R. Grishin – MD, PhD, Cardiovascular Surgeon, Department of Cardiovascular Surgery

Tretya Cherepkovskaya 15а, Moscow, 121552

O. A. Nikolaeva
National Medical Research Center of Cardiology
Russian Federation

Olga A. Nikolaeva – Junior Researcher, Laboratory of Interventional Treatment of Heart Rhythm Disorders, Department of Cardiovascular Surgery

Tretya Cherepkovskaya 15а, Moscow, 121552

R. S. Akchurin
National Medical Research Center of Cardiology
Russian Federation

Renat S. Akchurin – MD, PhD, Professor, Academician of the Russian Academy of Sciences, Head of Department of Cardiovascular Surgery, Deputy Director General for Surgery

Tretya Cherepkovskaya 15а, Moscow, 121552


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For citation:

Sapelnikov O.V., Kulikov A.A., Cherkashin D.I., Grishin I.R., Nikolaeva O.A., Akchurin R.S. Atrial Fibrillation: Development Mechanisms, Approaches and Prospects of Therapy. Rational Pharmacotherapy in Cardiology. 2020;16(1):118-125. (In Russ.)

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