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Markers of Endothelial Dysfunction: E-selectin, Endothelin-1 and von Willebrand Factor in Patients with Coronary Heart Disease, Including in Combination with Type 2 Diabetes Mellitus

https://doi.org/10.20996/1819-6446-2019-15-6-892-899

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Abstract

The prevalence of coronary heart disease (CHD) and type 2 diabetes mellitus (type 2 diabetes) in Russia and in the world continues to increase. Despite the prevention and optimization of therapy, CHD retains its leadership among all causes of death, and the mortality rate from type 2 diabetes and its complications gradually increases too. To improve the treatment of the above mentioned diseases, it is necessary to clarify the pathogenetic mechanisms of their development. The formation of endothelial dysfunction, characterized by an increase in the level of cell adhesion molecules and vasoconstriction, is a common link characteristic for the course and progression of CHD and type 2 diabetes. This article presents an analysis of preand clinical studies on the role of endothelial dysfunction markers: cell adhesion molecules (E-selectin), vasoconstriction (endothelin-1) and von Willebrand factor in patients with CHD, including those with type 2 diabetes mellitus.

About the Authors

A. V. Zhito
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexey V. Zhito – MD, Postgraduate Student, Chair of Hospital Therapy №1

Trubetskaya ul. 8-2, Moscow, 119991



A. O. Iusupova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alfia O. Iusupova – MD, PhD, Associate Professor, Chair of Hospital Therapy №1

Trubetskaya ul. 8-2, Moscow, 119991



E. V. Privalova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena V. Privalova – MD, PhD, Professor, Chair of Hospital Therapy №1

Trubetskaya ul. 8-2, Moscow, 119991



N. V. Khabarova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Natalia V. Khabarova – MD, PhD, Assistant, Chair of Hospital Therapy №1

Trubetskaya ul. 8-2, Moscow, 119991



Yu. N. Belenkov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Yurii N. Belenkov – MD, PhD, Professor, Academician of the Russian Academy of Sciences, Head of Chair of Hospital Therapy №1

Trubetskaya ul. 8-2, Moscow, 119991



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For citation:


Zhito A.V., Iusupova A.O., Privalova E.V., Khabarova N.V., Belenkov Yu.N. Markers of Endothelial Dysfunction: E-selectin, Endothelin-1 and von Willebrand Factor in Patients with Coronary Heart Disease, Including in Combination with Type 2 Diabetes Mellitus. Rational Pharmacotherapy in Cardiology. 2019;15(6):892-899. (In Russ.) https://doi.org/10.20996/1819-6446-2019-15-6-892-899

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