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How to solve the problem of drug choice within the same class from the standpoint of evidence-based medicine?

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The question of the possibility of the most effective drug choosing within one class from the standpoint of evidence-based medicine is considered in the article. Drugs belonging to the same class may have both great similarities and significant differences. This is demonstrated by the example of different classes of drugs (beta-blockers, angiotensin-converting enzyme inhibitors, and new oral anticoagulants). The choice of the most effective (from the standpoint of evidence-based medicine) is impossible if there are no direct comparisons in randomized controlled studies between drugs of the same class that have demonstrated their effectiveness separately. Analysis of observational studies (large databases, registers) to identify the most effective drug in a class cannot be used to solve the problem of the superiority of a drug within a class.

About the Author

S. Yu. Martsevich
National Medical Research Center for Preventive Medicine
Russian Federation

Sergey Yu. Martsevich - MD, PhD, Professor, Head of Preventive Pharmacotherapy Department.

Petroverigsky per. 1 0, Moscow, 101990


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For citation:

Martsevich S.Y. How to solve the problem of drug choice within the same class from the standpoint of evidence-based medicine? Rational Pharmacotherapy in Cardiology. 2019;15(2):271-276. (In Russ.)

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)