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Cardiorenal relationships in the focus of risks of atrial fibrillation in patients after acute ST-elevated myocardial infarction (observational program FAKEL)

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Aim. To study markers of renal dysfunction in relation to the likelihood of atrial fibrillation (AF) in patients after ST-segment elevated myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

Material and methods. The study was conducted with the inclusion of 1 52 patients discharged for outpatient monitoring after STEMI. There were 4 visits: V1 - inclusion visit, V2 - in 12 months, V3 - in 18 months, V4- in 24 months with determination of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP), cystatin C, erythropoietin, galectin-3, von Willebrand factor (fW), left ventricular ejection fraction. Endpoint: new cases of AF, cardioembolic stroke, deaths.

Results. After 24 months 35 patients (23.0%) were diagnosed with AF, 6 of them (3.9%) - developed cardioembolic stroke. The multivariate model of risk factors for AF included indicators: cystatin C (odds ratio [OR] 1.31; 95% confidence interval [95%CI] 1.03-1.67), NT-ProBNP (OR 1.11; 95%CI 1.03-1.19), galectin-3 (OR 0.71; 95%CI 0.55-0.91), fV (OR 0.71; 95%CI 0.55-0.91).

Conclusion. The prognostic significance of cystatin C in relation to the risk of AF was established, which should be considered when assessing the prognosis in patients after STEMI.

About the Authors

I. A. Zolotovskaya
Samara State Medical University
Russian Federation

Irina A. Zolotovskaya - MD, PhD, Associate Professor, Chair of Hospital Therapy with a Course in Outpatient Treatment and Transfusion Medicine.

Chapaevskaya ul. 89, Samara, 443099

I. L. Davydkin
Samara State Medical University
Russian Federation

Igor L. Davydkin - MD, PhD, Professor, Head of Chair of Hospital Therapy with a Course in Outpatient Treatment and Transfusion Medicine, Director of Research and Development Institute of Hematology, Transfusion and Intensive Care.

Chapaevskaya ul. 89, Samara, 443099

D. V. Duplyakov
Samara State Medical University
Russian Federation

Dmitry V. Duplyakov - MD, PhD, Professor, Chair of Cardiology and Cardiovascular Surgery.

Chapaevskaya ul. 89, Samara, 443099

V. A. Kokorin
Pirogov Russian National Research Medical University
Russian Federation

Valentin A. Kokorin - MD, PhD, Associate Professor, Chair of Hospital Therapy No. 1.

Ostrovitianova ul. 1, Moscow, 1 1 7997


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For citations:

Zolotovskaya I.A., Davydkin I.L., Duplyakov D.V., Kokorin V.A. Cardiorenal relationships in the focus of risks of atrial fibrillation in patients after acute ST-elevated myocardial infarction (observational program FAKEL). Rational Pharmacotherapy in Cardiology. 2019;15(2):159-165. (In Russ.)

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