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Prolonged Successful Cardiopulmonary Resuscitation with Thrombolysis in a Patient with Acute Coronary Syndrome

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A case of successful cardiopulmonary resuscitation lasting 120 min with a good neurological outcome in a patient with acute coronary syndrome is presented. The protocol of resuscitation with the use of thrombolysis (recombinant non-immunogenic staphylokinase) followed by stenting of the infarct-dependent artery in a patient with acute coronary syndrome is described on the example of this case.

About the Authors

G. V. Klein
Murmansk Regional Clinical Hospital named after P.A. Bayandin
Russian Federation
Head of the Department of Anesthesiology and Resuscitation №2

S. E. Chukseev
Murmansk Regional Clinical Hospital named after P.A. Bayandin
Russian Federation
anesthesiologist-resuscitator, Department of Anesthesiology and Resuscitation №2

M. A. Nikolaev
Murmansk Regional Clinical Hospital named after P.A. Bayandin
Russian Federation
doctor, Department of X-ray surgical diagnostic and treatment methods

A. A. Timofeev
Murmansk Regional Clinical Hospital named after P.A. Bayandin
Russian Federation
Head of the Department of Neurology for patients with acute disorders of cerebral circulation


1. Sanna T., La Torre G., de Waure C. et al. Cardiopulmonary resuscitation alone vs. Cardiopulmonary resuscitation plus automated external defibrillator use by non-healthcare professionals: A meta-analysis on 1583 cases of out-of-hospital cardiac arrest. Resuscitation. 2008;76(2):226-32. doi:10.1016/j.resuscitation.2007.08.001.

2. Wong C.X., Brown A., Lau D.H. et al. Epidemiology of Sudden Cardiac Death: Global and Regional Perspectives. Heart Lung Circ. 2019;28(1):6-14. doi:10.1016/j.hlc.2018.08.026.

3. Bockeria O.L., Biniashvili M.B. Sudden cardiac death and ischemic heart disease. Annaly Aritmologii. 2013;2:69-79. (In Russ.)

4. Moroz V.V., Bobrinskaya I.G., Vasilyev V.Yu. et al. Cardiopulmonary resuscitation. Study guide. Moscow: NIIOR, MGMSU; 2017. (In Russ.)

5. Sasson C., Rogers M.A., Dahl J., Kellermannn A.L. Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2010;3(1):63-81. doi:10.1161/CIRCOUTCOMES.109.889576.

6. Ward K.R., Kurz M.C., Neumar R.W. Adult resuscitation. In: Marx J.A., ed. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, PA: Elsevier/Saunders; 2014: 88-97.

7. Böttiger B.W., Arntz H.R., Chamberlain D.A. et al. Thrombolysis during resuscitation for out- of-hospital cardiac arrest. N Engl J Med. 2008;359(25):2651-662. doi:10.1056/NEJMoa070570.

8. Wetsch W.A., Spöhr F., Teschendorf P. et al. Thrombolysis during cardio-pulmonary resuscitation. Dtsch Med Wochenschr. 2010;135(40):1983-8. doi:10.1055/s-0030-1263347.

9. Nusbaum D.M., Bassett S.T., Gregoric I.D., Kar B. A Case of Survival after Cardiac Arrest and 31/2 Hours of Resuscitation. Tex Heart Inst J. 2014;41(2):222-6. doi:10.14503/THIJ-13-3192.

10. Jollis J.G., Granger C.B. Improving Care of Out-of-Hospital Cardiac Arrest Next Steps. Сirculаtion. 2016;134:2040-2. doi:10.1161/CIRCULATIONAHA.116.025818.

11. Reynolds J.C., Grunau B.E., Rittenberger J.C., et al. Association Between Duration of Resuscitation and Favorable Outcome After Out-of-Hospital Cardiac Arrest Implications for Prolonging or Terminating Resuscitation. Circulation. 2016;134:2084-94. doi:10.1161/CIRCULATIONAHA. 116.023309.

12. Hamel E., Pacouret G., Vincentelli D. et al. Thrombolysis or heparin therapy in massive pulmonary embolism with right ventricular dilation: results from a 128-patient monocenter registry. Chest. 2001;120(1):120-5. doi:10.1378/chest.120.1.120.

13. Shih C.L., Lu T.C., Jerng J.S. et al. A web-based Utstein style registry system of in-hospital cardiopulmonary resuscitation in Taiwan. Resuscitation. 2007;72(3):394-40. doi:10.1016/j.resuscitation.2006.07.020.

14. Youness H., Al Halabi T., Hussein H. et al. Review and Outcome of Prolonged Cardiopulmonary Resuscitation. Crit Care Res Pract. 2016;2016:7384649. doi:10.1155/2016/7384649.

15. Wada T. Coagulofibrinolytic Changes in Patients with Post-cardiac Arrest Syndrome. Front Med (Lausanne). 2017;4:156. doi:10.3389/fmed.2017.00156.

16. Klinge U., Klosterhalfen B., Töns C., Schumpelick V. A bleeding complication as a consequence of bolus lysis after resuscitation. Dtsch Med Wochenschr. 1991;116(34):1293.

17. Kurkciyan I., Meron G., Sterz F. et al. Major bleeding complications after cardiopulmonary resuscitation: impact of thrombolytic treatment. J Intern Med. 2003;253(2):128-35. doi:10.1046/j.1365-2796.2003.01079.x.

18. Böttiger B.W., Arntz H.R., Chamberlain D.A. et al. TROICA Trial Investigators; European Resuscitation Council Study Group. Thrombolysis during resuscitation for out-of-hospital cardiac arrest. N Engl J Med. 2008;359(25):2651-62. doi:10.1056/NEJMoa070570.

19. Bozeman W.P., Kleiner D.M., Ferguson K.L. Empiric tenecteplase is associated with increased return of spontaneous circulation and short-term survival in cardiac arrest patients unresponsive to standard interventions. Resuscitation. 2006;69(3):399-406. doi:10.1016/j.resuscitation.2005.09.027.

20. Markov V.A., Duplyakov D.V., Konstantinov S.L., et al. Fortelisin® versus Metalyze® for ST segment elevation myocardial infarction: results of a multicenter randomized study FRIDOM1. Kardiologicheskiy Vestnik. 2017;3:52-9. (In Russ.)

21. Markin S.S., Semenov A.M., Markov V.A. et al. Study of the new domestic thrombolytic drug Fortelizin® in patients with acute myocardial infarction. Sibirskiĭ Meditsinskiĭ Jurnal. 2012;12(1):27-32. (In Russ.)

22. Vyishilov E.V., Alekseeva YA.V., Gerasimets E.A., Markov V.A. Experimental and clinical studies of staphylokinase and Fortelizin. Kardiologiya. 2017;2:57-61. (In Russ.)

23. Perkins G.D., Handley A.J., Koster R.W. et al. European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. Adult basic life support and automated external defibrillation. Resuscitation. 2015;95:81-99. doi:10.1016/j.resuscitation.2015.07.015.


For citations:

Klein G.V., Chukseev S.E., Nikolaev M.A., Timofeev A.A. Prolonged Successful Cardiopulmonary Resuscitation with Thrombolysis in a Patient with Acute Coronary Syndrome. Rational Pharmacotherapy in Cardiology. 2018;14(6):864-869.

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ISSN 1819-6446 (Print)
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