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Basic Anthropometric Indices and Diabetes Mellitus Type 2 in Russian Population

O. M. Drapkina, R. N. Shepel, S. A. Shalnova, A. D. Deev, Yu. A. Balanova, S. E. Evstifeeva, Yu. V. Zhernakova, A. E. Imaeva, A. V. Kapustina, G. A. Muromtseva, O. P. Rotar, E. V. Shlyakhto, S. A. Boytsov

Kulakova N.V., Nevzorova V.A., Shestakova N.V., Mokshina M.V., Rodionova L.V., Tolparov G.V., Shabunova A.A., Kalashnikov K.N., Kalachikova O.N., Popov A.V., Nedogoda S.V., Chumachek E.V., Lediaeva A.A., Chernyih T.M., Furmenko G.I., Ovsyannikova V.V., Bondarcov L.V., Belova O.A., Romanchuk S.V., Nazarova O.A., Shutemova O.A., Barbarash O.L., Artamonova G.V., Indukaeva E.V., Mulerova T.A., Maksimov S.A., Skripchemko A.E., Cherkass N.V., Tabakaev M.V., Danilchenko Ia.V., Grinshtein Yu.I., Petrova M.M., Danilova L.K., Evsiukov A.A., Shabalin V.V., Ruph R.R., Kosinova A.A., Filonenko I.V., Baykova O.A., Gomyranova N.V., Oganov R.G., Oshepkova E.V., Libis R.A., Basyrova I.R., Lopina E.A., Dupliakov D.V., Gudkova S.A., Cherepanova N.A., Konradi A.O., Baranova E.I., Trubacheva I.A., Kaveshnikov V.S., Karpov R.S., Serebriakova V.N., Efanov A. Yu., Medvedeva I.V., Storozhok M.A., Shalaev S.V.

https://doi.org/10.20996/1819-6446-2018-14-5-725-732

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Abstract

Obesity is one of the main risk factors for type 2 diabetes developing. The question of the advantages and disadvantages of using various anthropometric indices [body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHR), lipid accumulation product index (LAPI), visceral obesity index (VOI)] has been under discussion lately.

Aim. To perform an analysis of anthropometric obesity indicators (BMI, WC, WHR, VOI, LAPI) depending on the presence of type 2 diabetes in the adult population of the Russian Federation.

Material and methods. The results of the study "Epidemiology of Cardiovascular diseases and their risk factors in the regions of the Russian Federation" (ESSE-RF) performed in 2012-2014 in 13  regions of the Russian Federation are included into the analysis. People aged  25-64 years (n=20878; 8058 men and 12820 women) were examined. The following indicators in people with/without type 2 diabetes were analyzed: age; sex; anthropometric indicators: height, weight, WC; smoking status  (“never smoked”, “smoked”,  “smokes  now”); alcohol consumption, which was ranked  for “never in the last year” and “a lot” (≥168 g of ethanol per week for men and ≥84 g of ethanol per week for women); the level of systolic (SBP) and diastolic (DBP) blood pressure; heart  rate (HR); levels of glucose, total cholesterol (TC), high density lipoproteins cholesterol (HDL-C), triglycerides (TG); WHR; VOI; LAPI, BMI.

Results. Levels of TC and glucose, excessive alcohol consumption, BMI were selected in a multifactor regression model in men after adjusting for age, region of residence and IVO. The same factors (SBP instead of alcohol and BMI instead of WHR were included in the model) were selected in women. VOI showed the greatest degree of association with type 2 diabetes regardless of gender after adjusting for age and region of residence (in men odds ratio 1,085; p=0.0001; in women odds  ratio 1,136; p=0.0001). Thus, VOI (predictor of type  2 diabetes in population of working age) was common to both sexes.

Conclusion. VOI has statistically significant associations with type 2 diabetes. VOI is the best surrogate marker for measuring the degree of abdominal obesity in the Russian population and can be used to determine the presence of type 2 diabetes in clinical practice. Screening for elevated VOI values in healthy individuals and patients with pre-diabetes can serve as a guide for targeted aggressive preventive interventions.

Participants of the  ESSE-RF Study: Vladivostok: Kulakova N.V., Nevzorova  V.A., Shestakova N.V., Mokshina M.V., Rodionova L.V.; Vladikavkaz: Tolparov G.V.; Vologda: Shabunova A.A., Kalashnikov K.N., Kalachikova O.N.,  Popov  A.V.; Volgograd: Nedogoda S.V., Chumachek E.V., Lediaeva A.A.; Voronezh: Chernyih T.M., Furmenko G.I., Ovsyannikova V.V., Bondarcov L.V.; Ivanovo: Belova O.A., Romanchuk S.V., Nazarova  O.A., Shutemova O.A.; Kemerovo: Barbarash O.L., Artamonova G.V., Indukaeva E.V., Mulerova T.A., Maksimov S.A., Skripchemko A.E., Cherkass  N.V., Tabakaev M.V., Danilchenko Ia.V.; Krasnoyarsk: Grinshtein Yu.I., Petrova M.M., Danilova L.K., Evsiukov A.A., Shabalin V.V., Ruph R.R., Kosinova A.A., Filonenko I.V., Baykova O.A.; Moscow: Gomyranova N.V., Oganov  R.G., Oshepkova E.V.; Orenburg: Libis R.A., Basyrova I.R., Lopina E.A.; Samara: Dupliakov D.V., Gudkova S.A., Cherepanova N.A.; St. Petersburg: Konradi A.O., Baranova E.I.; Tomsk: Trubacheva I.A., Kaveshnikov V.S., Karpov R.S., Serebriakova V.N.; Tyumen: Efanov A. Yu., Medvedeva I.V., Storozhok  M.A., Shalaev S.V.


About the Authors

O. M. Drapkina
National Medical Research Center for Preventive Medicine
Russian Federation

Oxana M. Drapkina – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Director.

Petroverigsky per. 10,  Moscow, 101990.

 



R. N. Shepel
National Medical Research Center for Preventive Medicine
Russian Federation

Ruslan N. Shepel – MD, PhD, Head of Department of Organizational and Methodological Management and Organization of the Quality of Medical Care; Junior Researcher,  Department of Fundamental and Applied Aspects of Obesity.

Petroverigsky per. 10,  Moscow, 101990.

 



S. A. Shalnova
National Medical Research Center for Preventive Medicine
Russian Federation

Svetlana A. Shalnova – MD, PhD, Professor, Head of Department of Epidemiology of Chronic Non-Communicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



A. D. Deev
National Medical Research Center for Preventive Medicine
Russian Federation

Alexander D. Deev – PhD (Physics and Mathematics), Head of Laboratory of Biostatistics, Department of Epidemiology of Chronic Non-Communicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



Yu. A. Balanova
National Medical Research Center for Preventive Medicine
Russian Federation

Yulia A. Balanova – MD, PhD, Leading Researcher,  Laboratory of Economic Analysis of Epidemiological Researches  and Preventive Technologies, Department of Epidemiology of Chronic Non-Communicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



S. E. Evstifeeva
National Medical Research Center for Preventive Medicine
Russian Federation

Svetlana E. Evstifeeva – MD, PhD, Senior Researcher,  Department of Epidemiology of Chronic Non-Communicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



Yu. V. Zhernakova
National Medical Research Centre of Cardiology
Russian Federation

Yulia V. Zhernakova – MD, PhD, Senior Researcher.

Tretya Cherepkovskaya ul. 15А, Moscow, 121552.

 



A. E. Imaeva
National Medical Research Center for Preventive Medicine
Russian Federation

Asia E. Imaeva – MD, PhD, Senior Researcher,  Department of Epidemiology of Chronic Non-Communicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



A. V. Kapustina
National Medical Research Center for Preventive Medicine
Russian Federation

Anna V. Kapustina – MD, PhD, Senior Researcher,  Department of Epidemiology of Chronic Noncommunicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



G. A. Muromtseva
National Medical Research Center for Preventive Medicine
Russian Federation

Galina A. Muromtseva – PhD (in Biology), Leading Researcher, Department of Epidemiology of Chronic Non-Communicable Diseases.

Petroverigsky per. 10,  Moscow, 101990.

 



O. P. Rotar
Almazov National Medical Research Centre
Russian Federation

Oxana P. Rotar – MD, PhD, Head of Laboratory for Epidemiology of Arterial Hypertension.

Akkuratova ul. 2, St. Petersburg, 197341.

 



E. V. Shlyakhto
Almazov National Medical Research Centre
Russian Federation

Evgeny V. Shlyakhto – MD, PhD, Professor, Academician of the Russian Academy of Sciences, Director.

Akkuratova ul. 2, St. Petersburg, 197341.

 



S. A. Boytsov
National Medical Research Centre of Cardiology
Russian Federation

Sergey A. Boytsov – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, General Director.

Tretya Cherepkovskaya ul. 15А, Moscow, 121552.

On behalf of the participants of the ESSE-RF epidemiological study.




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For citation:


Drapkina O.M., Shepel R.N., Shalnova S.A., Deev A.D., Balanova Y.A., Evstifeeva S.E., Zhernakova Y.V., Imaeva A.E., Kapustina A.V., Muromtseva G.A., Rotar O.P., Shlyakhto E.V., Boytsov S.A. Basic Anthropometric Indices and Diabetes Mellitus Type 2 in Russian Population. Rational Pharmacotherapy in Cardiology. 2018;14(5):725-732. (In Russ.) https://doi.org/10.20996/1819-6446-2018-14-5-725-732

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