Preview

Rational Pharmacotherapy in Cardiology

Advanced search

Association of Conventional Cardiovascular Risk Factors with Carotid Atherosclerosis Prevalence in General Population

https://doi.org/10.20996/1819-6446-2018-14-4-552-557

Full Text:

Abstract

Material and methods. In the cross-sectional population-based study of general unorganized population of Tomsk aged 25-64 years ultrasound screening examination of the carotid arteries was done for detection of atherosclerotic plaques (plaque). As potential plaque determinants the following factors were studied: age, gender, smoking, low and high density lipoproteins (LDL-C and HDL-C), triglycerides, arterial hypertension, body mass index (BMI), low educational status (LES), high-sensitive C-reactive protein, glucose, diabetes mellitus, antihypertensive and hypolipidemic therapy. Study of relationships was carried out with logistic regression analysis. The error probability of less than 5% was considered statistically significant.

Results. In the crude analysis most of the determinants under study showed statistically significant relationship with plaque presence. After adjustment for age and sex, LDL-C, smoking and LES were associated with CAS prevalence. In multivariable regression analysis 9 risk factors appeared to be independently associated with plaque presence, wherein age, male sex, LDL-C, BMI and HDL-C were the most significant. In the participants of 50 years and older the smoking effect was the next in significance after LDL-C.

Conclusion. The results obtained focus attention on the comparative value of the major atherogenic risk factors and suggest that currently effective and timely control of LDL-C is of primary importance for prevention of carotid atherosclerosis in the general working-age population. As well the findings of the study evidence that at the population level smoking is still one of the leading atherogenic risk factors.

About the Authors

V. S. Kaveshnikov
Tomsk National Research Medical Center, Cardiology Research Institute
Russian Federation

Vladimir S. Kaveshnikov – MD, PhD, Senior Researcher, Population Cardiology Department

Kievskaya ul. 111a, Tomsk, 634012



V. N. Serebryakova
Tomsk National Research Medical Center, Cardiology Research Institute
Russian Federation

Victoriya N. Serebryakova – MD, PhD, Senior Researcher, Population Cardiology Department 

Kievskaya ul. 111a, Tomsk, 634012



I. A. Trubacheva
Tomsk National Research Medical Center, Cardiology Research Institute
Russian Federation

Irina A. Trubacheva – MD, PhD, Head of Population Cardiology Department 

Kievskaya ul. 111a, Tomsk, 634012



S. A. Shalnova
National Medical Research Center for Preventive Medicine
Russian Federation

Svetlana A. Shalnova – MD, PhD, Professor, Head of Department of Epidemiology of Chronic Non-Communicable Diseases 

Petroverigsky per. 10, Moscow, 101990



References

1. Scientific Organizing Committee of the RF-ESSAY. Epidemiology of cardiovascular disease in different regions of Russia (ESSAY-RF). Rationale and study design. Preventive Medicine. 2013;6:25-34. (In Russ)

2. Johnsen S.H., Ellisiv B.M. Ultrasound imaging of carotid atherosclerosis in a normal population. The Tromso Study. Norsk Epidemiologi. 2009;19(1):17-28. doi: 10.1007/s10654-009-9322-2.

3. Inaba Y., Chen J.A., Bergmann S.R. Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis. Atherosclerosis. 2012;220(1):128-33. doi: 10.1016/j.atherosclerosis.2011.06.044.

4. Ikeda N., Kogame N., Iijima R. et al. Carotid artery intima-media thickness and plaque score can predict the SYNTAX score. Eur Heart J. 2012;33(1):113-9. doi: 10.1093/eurheartj/ehr399.

5. Prati P., Vanuzzo D., Casaroli M. et al. Prevalence and determinants of carotid atherosclerosis in a general population. Stroke. 1992;23(12):1705-11.

6. Rundek T., Arif H., Boden-Albala B. et al. Carotid plaque, a subclinical precursor of vascular events: The Northern Manhattan Study. Neurology. 2008;70(14):1200-07. doi: 10.1212/01.wnl.0000303969.63165.34.

7. Lanktree M.B., Hegele R.A., Schork N.J. et al. Extremes of unexplained variation as a phenotype: an efficient approach for genome-wide association studies of cardiovascular disease. Circ Cardiovasc Genet. 2010;3(2):215-21. doi: 10.1161/CIRCGENETICS.109.934505.

8. Spence J.D., Eliasziw M., DiCicco M. et al. Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy. Stroke. 2002;33:2916-22.

9. Joakimsen O., Bonaa K.H., Stensland-Bugge E. et al. Age and Sex Differences in the Distribution and Ultrasound Morphology of Carotid Atherosclerosis: The Tromso Study. Arterioscler Thromb Vasc Biol. 1999;19:3007-13.

10. Fabris F., Zanocchi M., Bo M. et al. Carotid plaque, aging, and risk factors. A study of 457 subjects. Stroke. 1994;25(6):1133-40.

11. Lee Y.H., Cui L.H., Shin M.H. et al. Associations between carotid intima-media thickness, plaque and cardiovascular risk factors [Article in Korean. J Prev Med Public Health. 2006;39(6):477-84.

12. Willeit J., Kiechl S. Prevalence and risk factors of asymptomatic extracranial carotid artery atherosclerosis. A population-based study. Arterioscler Thromb. 1993;13(5):661-8.

13. Zhernakova Yu.V., Kaveshnikov V.S., Serebriakova V.N. et al. The prevalence of carotid atherosclerosis in spontaneous populations in Tomsk. Systemic Hypertension. 2014;11(4):37-42. (In Russ)

14. Chazova I.E., Trubacheva I.A., Zhernakova Yu.V. et al. The prevalence of arterial hypertension as a risk factor of cardiovascular diseases in one of the cities in Siberian Federal District. Systemic Hypertension. 2013;10(4):30-7. (In Russ)

15. Kuo F., Gardener H., Dong C. et al. Traditional cardiovascular risk factors explain the minority of the variability in carotid plaque. Stroke. 2012; 43(7):1755-60. doi: 10.1161/STROKEAHA. 112.651059.

16. Perk J., De Backer G., Gohlke H. et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). Eur Heart J. 2012;33(13):1635-701. doi: 10.1093/eurheartj/ ehs092.

17. Kaveshnikov V.S., Serebryakova V.N., Trubacheva I.A. et al. Descriptive model of carotid atherosclerosis prevalence in adult urban population of Siberian region. Sib Med J (Tomsk) 2015; 30(2):131-6. (In Russ)

18. Yang C., Sun Z., Li Y. et al. The correlation between serum lipid profile with carotid intima-media thickness and plaque. BMC Cardiovasc Disord. 2014;14:181. doi: 10.1186/1471-2261-14-181.

19. Gardener H., Della Morte D., Elkind M.S. et al. Lipids and carotid plaque in the Northern Manhattan Study (NOMAS). BMC Cardiovasc Disord. 2009;9:55. doi: 10.1186/1471-2261-9-55.

20. Nash S.D., Cruickshanks K.J., Klein R. et al. Socioeconomic status and subclinical atherosclerosis in older adults. Prev Med. 2011;52:208-12. doi: 10.1016/j.ypmed.2010.12.009.

21. Trubacheva I.A., Perminova O.A., Shatrov S.V. et al. Knowledge and arterial hypertension in adult population of Tomsk (population sampling study). Sib Med J (Tomsk). 2004;19(4):75-81. (In Russ)

22. Berger J.S., Jordan C.O., Lloyd-Jones D. Screening for cardiovascular risk in asymptomatic patients. J Am Coll Cardiol. 2010;55(12):1169-77. doi: 10.1016/j.jacc.2009.09.066.

23. Kaveshnikov V.S., Trubacheva I.A., Serebryakova V.N. Role of tobacco smoking in the formation of up to date public health indicators. Sib Med J (Tomsk). 2011;26(1):15-22. (In Russ)


For citation:


Kaveshnikov V.S., Serebryakova V.N., Trubacheva I.A., Shalnova S.A. Association of Conventional Cardiovascular Risk Factors with Carotid Atherosclerosis Prevalence in General Population. Rational Pharmacotherapy in Cardiology. 2018;14(4):552-557. (In Russ.) https://doi.org/10.20996/1819-6446-2018-14-4-552-557

Views: 132


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)