Preview

Rational Pharmacotherapy in Cardiology

Advanced search

Influence of Childhood and Adulthood Obesity on Arterial Stiffnes and Central Blood Pressure in Men

https://doi.org/10.20996/1819-6446-2018-14-4-543-551

Full Text:

Abstract

Aim. To study the effect of obesity in childhood and adulthood on the indices of arterial stiffness, central aortic pressure in the population sample of men 42 to 43 years.

Methods. The study is part of a 32-year prospective cohort monitoring of males, beginning with childhood (11-12 years). 303 (30.1%) of the representatives of the initial population sample (n=1005) were examined after 32 years. 290 people are included into the analysis. The average age of men at the time of the examination was 42.9 years. The study included a survey on a standard questionnaire, measurement of anthropometric indicators, blood pressure (BP), pulse counting. The stiffness of the arterial wall and central pressure was measured by the applanation tonometry.

Results. Normal body weight was found in 95 of 290 men (32.8%) at the age of 43 years, weight gain – in 111 (38.3%) and obesity – in 84 (28.9%). Men with obesity and overweight in adulthood had a statistically significant increase in body weight as early as in childhood. Central aortic BP (CBP), as a surrogate vascular rigidity index, was statistically significantly higher in obesity and overweight groups. A statistically significant positive relationship between the indicators characterizing childhood obesity (the Quetelet index, the thickness of skin folds), and the level of blood pressure in childhood was found in the correlation analysis. A positive correlation between the thickness of skin folds in childhood with CBP in adulthood, as well as a weak positive relationship between peripheral systolic BP (pSBP) in childhood and central systolic BP (cSBP) in adulthood have been found. From potential predictors evaluated at the age of 12 years and included in the regression model only the thickness of the skin fold under the scapula

affected cSBP at the age of 43. The increase in the thickness of skin fold under the scapula in childhood at1 mmis associated with an increase in сSBP by0.4 mmHg in the adult state. Among the predictors evaluated in adulthood, pSBP, peripheral diastolic BP (pDBP), and the Quetelet index have a statistically significant effect on the level of cSBP. The thickness of the skin fold on the abdomen at the age of 12 influenced central diastolic BP (cDBP) level at the age of43. Astatistically significant effect on the cDBP level was provided by pDBP, obesity rates among potential predictors evaluated in adulthood.

Conclusion. Central aortic pressure in adulthood is maximally dependent on increased peripheral blood pressure and obesity. Only obesity was important among children's predictors (12 years of age).

About the Authors

O. Yu. Isaykina
National Medical Research Center for Preventive Medicine
Russian Federation

Olesya Yu. Isaykina – MD, PhD, Senior Researcher, Laboratory of Outpatient Diagnostic Methods in Prevention of ChronicNon-Communicable Diseases

Petroverigsky per. 10, Moscow, 101990



V. B. Rozanov
National Medical Research Center for Preventive Medicine
Russian Federation

Vyatcheslav B. Rozanov – MD, PhD, Leading Researcher, Laboratory of Chronic Non-Communicable Diseases Prevention in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System, National Medical Research Center for Preventive Medicine; Leading Specialist, Department of Public Health, Institute for Leadership and Healthcare Management, Sechenov University 

Trubetskaya ul. 8-2, Moscow, 119991 



A. A. Alexandrov
National Medical Research Center for Preventive Medicine
Russian Federation

Alexander A. Alexandrov – MD, PhD, Professor, Head of Laboratory of Chronic Non-Communicable Diseases Prevention in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System

Petroverigsky per. 10, Moscow, 101990



E. I. Ivanova
National Medical Research Center for Preventive Medicine
Russian Federation

Elena I. Ivanova – Researcher, Laboratory of ChronicNon-Communicable Diseases Prevention in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System 

Petroverigsky per. 10, Moscow, 101990



H. S. Pugoeva
National Medical Research Center for Preventive Medicine
Russian Federation

Hava S. Pugoeva – MD, Junior Researcher, Laboratory of Chronic Non-Communicable Diseases Prevention in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System 

Petroverigsky per. 10, Moscow, 101990

 



References

1. Luscher Т.F. Prevention is better than cure: the new ESC Guidelines. Eur Heart J. 2016;37:2291-3. doi:10.1093/eurheartj/ehw321.

2. European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. Eur Heart J. 2013;34:2159-219. doi: 10.1093/eurheartj/eht151.

3. Whitaker R.C., Wright J.A., Pepe M.S., et al. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997;337(13):869-73. doi: 10.1056/NEJM199709253371301.

4. Krebs N.F., Jacobson M.S.; American Academy of Pediatrics Committee on Nutrition. Prevention of pediatric overveight and obesity. Pediatrics. 2003;112:424-30.

5. Freedman D.S., Dietz W.H., Serdula M.K. et al. The Relation of Childhood BMI to Adult Adiposity: The Bogalusa Heart Study. Pediatrics. 2005;115:22-27. doi: 10.1542/peds.2004-0220.

6. Wildman R.P., Mackey R.H., Bostom A., et al. Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension. 2003;42:468-73. doi: org/10.1161/01.HYP. 0000090360.78539.

7. Rider O.J., Tayal U., Francis J.M., et l. The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging. Obesity (Silver Spring). 2010;18:2311-6. doi: 10.1038/oby.2010.64.

8. Lurbe E., Torro I., Garcia-Vicent C., et al. Blood pressure and obesity exert independent influences on pulse wave velocity in youth. Hypertension. 2012;60:550-5. doi: 10.1161/HYPERTENSIONAHA.112.194746.

9. Charakida M., Jones A., Falaschetti E., et al. Childhood obesity and vascular phenotypes: a population study. J Am Coll Cardiol. 2012;60:2643-50. doi: 10.1016/j.jacc.2012.08.1017.

10. Corden B., Keenan N.G., de Marvao A.S., et al. Body Fat Is Associated with Reduced Aortic Stiffness Until Middle Age. Hypertension.2013;61:1322-27. doi: 10.1161/HYPERTENSIONAHA.113.01177.

11. O’Rourke M.F., Safar M.E., Nichols W.W. Pulse wave form analysis and arterial stiffness: realism can replace evangelism and scepticism [letter. J Hypertens. 2004;22(8):1633-4. doi: 10.1097/01. hjh.0000125473.35523.3f.

12. Obeid H., Ouedraogo V., Hallab M. Arterial Stiffness: A New Biomarker to be Measured. J Arch Mil Med. 2017;5(1):1-8. doi: 10.5812/jamm.47078.

13. Milyagin V.A., Komissarov V.B. Modern methods of evaluation of vascular stiffness. Arterial'naya Gipertenziya. 2010;16(2):134-43. (In Russ)

14. Laurent S., Cockcroft J., Van Bortel L. et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27(21):2588-605. doi: org/10.1093/eurheartj/ehl254.

15. Pichlera G., Martineza F., Vicentea A. et al. Influence of obesity in central blood pressure. Journal of Hypertension. 2015;33:308-13. doi:10.1097/HJH.0000000000000393.

16. Nilsson P.M., Khalili P., Franklin S.S. Blood pressure and pulse wave velocity as metrics for evaluating pathologic ageing of the cardiovascular system. Blood Press. 2014;23:17-30. doi: 10.3109/08037051.2013.796142.

17. Van Bortel L.M., Laurent S., Boutouyrie P., et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30:445-8. doi: 10.1097/HJH.0b013e32834fa8b0.

18. World Health Organization: Obesity and overweight. Fact sheet Updated October 2017. [cited by Aug 23, 2018. Available from: http://www.who.int/news-room/fact-sheets/detail/obesity-andoverweight.

19. Stamler J. Epidemic obesity in the United States. Arch Intern Med. 1993;153(9):1040-4. doi:10.1001/archinte.1993.00410090006001.

20. Burack R.C., Keller J.B., Higgins M.W. Cardiovascular risk factors and obesity: are baseline levels of blood pressure glucose cholesterol and uric acid elevated prior to weight gain? J Chronic Dis. 1985;38:865-72. doi: 10.1016/0021-9681(85)90111-0.

21. Isaykina O.Y., Rozanov V.B., Zvolinskaya E.Y., et al. Arterial Stiffness and Cardiovascular Risk Factors in Young Men (41-44 Years). Rational Pharmacotherapy in Cardiology. 2017;13(3):290-300. (In Russ.)

22. Pi-Sunyer F.X. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res. 2002;10(2):97-104. doi: 10.1038/oby.2002.202.

23. Montani J.P., Antic V., Yang Z., Dulloo A. Pathways from obesity to hypertension: from the perspective of a vicious triangle. Int J Obes. 2002;26(2):28-38. doi.org/10.1038/sj.ijo.0802125.

24. Li P., Wang L., Liu C. Overweightness, obesity and arterial stiffness in healthy subjects: A systematic review and metaanalysis of literature studies. J Postgraduate Medicine. 2017;129(2):224-30. doi:10.1080/00325481.2017.1268903.

25. Ceponiene I., Klumbiene J., Tamuleviciute-Prasciene E. Associations between risk factors in childhood (12-13 years) and adulthood (48-49 years) and subclinical atherosclerosis: the Kaunas Cardiovascular Risk Cohort Study. BMC Cardiovasc Disord. 2015;18(15):89. doi: 10.1186/s12872-0150087-0.

26. Chu C., Dai Y., Mu J., Yang R. Associations of risk factors in childhood with arterial stiffness 26 years later: the Hanzhong adolescent hypertension cohort. J Hypertens. 2017;35(1):10-5. doi:10.1097/HJH.0000000000001242.


For citation:


Isaykina O.Y., Rozanov V.B., Alexandrov A.A., Ivanova E.I., Pugoeva H.S. Influence of Childhood and Adulthood Obesity on Arterial Stiffnes and Central Blood Pressure in Men. Rational Pharmacotherapy in Cardiology. 2018;14(4):543-551. (In Russ.) https://doi.org/10.20996/1819-6446-2018-14-4-543-551

Views: 131


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)