Rational Pharmacotherapy in Cardiology

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Cardiovascular diseases occupy a leading position in morbidity, mortality and disability in most countries. Ischemic heart disease and stroke lead in the structure of mortality from cardiovascular diseases. The issues of lipid-lowering therapy with statins in the aspect of stroke prevention are discussed in the article. The main risk factors of atherosclerosis and their prevalence are presented. Topical standards for statin use, evidence-based medicine data obtained in randomized clinical trials, and evidence from actual clinical practice are covered. Possible promising areas of statin use for the prevention of acute cerebrovascular accident are also considered. Combination therapy together with other lipid-lowering drugs, as well as drugs of other pharmacological groups, the use of statins from earlier ages, the practical implementation of pleiotropic effects of statins can be attributed to the latter. The authors clearly demonstrate that the actual practice of using statins lags significantly behind the ideal, reflected in the recommendations and randomized clinical trials. Adherence to medical recommendations is one of the key factors in this. The main factors that can influence the increase of adherence of patients to taking statins and increase the effectiveness of their application in real clinical practice are presented.

About the Authors

O. V. Gaisenok
Joint Hospital and Polyclinic, Administrative Department of the President of the Russian Federation
Russian Federation

MD, PhD, Head of Department of General Cardiology, 

Michurinskiy prosp. 6, Moscow, 119285

A. N. Rozhkov
Central State Medical Academy, Administrative Department of the President of the Russian Federation
Russian Federation

MD, Resident, Chair of Therapy, Cardiology and Functional Diagnostics with the Course of Nephrology, 

Marshala Timoshenko ul. 19-1A, Moscow, 121359 

A. S. Lishuta
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

MD, PhD, Associate Professor, Chair of Hospital Therapy №1, 

Trubetskaya ul., 8-2, Moscow, 119991 


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For citation:

Gaisenok O.V., Rozhkov A.N., Lishuta A.S. HYPOLIPIDEMIC THERAPY IN STROKE PREVENTION: EXISTING STANDARDS, EVIDENCE-BASED MEDICINE DATA AND REAL PRACTICE. Rational Pharmacotherapy in Cardiology. 2018;14(3):434-440. (In Russ.)

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